Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 348
Gene Symbol: APOE
APOE
0.340 GeneticVariation group BEFREE We found that two loci, chromosome 1p13.3 near CELSR2 and PSRC1 which contains rs646776, and 19q13.2 near TOMM40 and APOE which contains rs2075650, harbor risk alleles for CAAD. 19951432 2009
Entrez Id: 348
Gene Symbol: APOE
APOE
0.340 Biomarker group CTD_human Risk of carotid atherosclerosis associated with genetic polymorphisms of apolipoprotein E and inflammatory genes among arsenic exposed residents in Taiwan. 18022660 2008
Entrez Id: 348
Gene Symbol: APOE
APOE
0.340 Biomarker group BEFREE These findings may further our understanding of VLDLR function, its ligand APOE, and ultimately the pathogenesis of CAAD in the general population. 18056683 2008
Entrez Id: 348
Gene Symbol: APOE
APOE
0.340 Biomarker group BEFREE In this cross-sectional study, 101 demented (68 AD and 33 VaD) patients underwent APOE genotyping and neck vessel ultrasound to evaluate carotid artery disease [intima-media thickness (IMT) and plaques]. 17539949 2007
Entrez Id: 348
Gene Symbol: APOE
APOE
0.340 Biomarker group BEFREE These two markers, along with CYP27, PPARgamma and apoE, provided predictive markers for the development of carotid artery disease within the SSc patient population. 12154203 2002
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.330 AlteredExpression group BEFREE In 91 patients treated for carotid artery disease, Ets2 levels showed modest correlations with capillary growth, thrombogenicity, and rising levels of tumor necrosis factor-α (TNFα), monocyte chemoattractant protein 1, and interleukin-6 in the atherosclerotic lesions. 21700929 2011
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.330 Biomarker group CTD_human Risk of carotid atherosclerosis associated with genetic polymorphisms of apolipoprotein E and inflammatory genes among arsenic exposed residents in Taiwan. 18022660 2008
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.330 Biomarker group LHGDN HIV-infected patients with lipodystrophy have higher rates of carotid atherosclerosis: the role of monocyte chemoattractant protein-1. 16697654 2006
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.330 GeneticVariation group LHGDN Polymorphism of the monocyte chemoattractant protein (MCP-1) gene is associated with the plasma level of MCP-1 but not with carotid intima-media thickness. 14620921 2003
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.310 Biomarker group BEFREE In this study, we sought to assess the role of HO-1 in the progression toward plaque instability in carotid artery disease in patients and in a murine model of vulnerable plaque development. 19487598 2009
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.310 Biomarker group CTD_human Microarray analysis reveals overexpression of CD163 and HO-1 in symptomatic carotid plaques. 17095719 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.310 Biomarker group CTD_human Effects of arsenic exposure and genetic polymorphisms of p53, glutathione S-transferase M1, T1, and P1 on the risk of carotid atherosclerosis in Taiwan. 16973168 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.310 GeneticVariation group LHGDN Effects of arsenic exposure and genetic polymorphisms of p53, glutathione S-transferase M1, T1, and P1 on the risk of carotid atherosclerosis in Taiwan. 16973168 2007
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.310 Biomarker group CTD_human Effects of arsenic exposure and genetic polymorphisms of p53, glutathione S-transferase M1, T1, and P1 on the risk of carotid atherosclerosis in Taiwan. 16973168 2007
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.310 GeneticVariation group LHGDN Effects of arsenic exposure and genetic polymorphisms of p53, glutathione S-transferase M1, T1, and P1 on the risk of carotid atherosclerosis in Taiwan. 16973168 2007
Entrez Id: 5420
Gene Symbol: PODXL
PODXL
0.300 Biomarker group CTD_human Diminished thrombogenic responses by deletion of the Podocalyxin Gene in mouse megakaryocytes. 22016802 2011
Entrez Id: 22808
Gene Symbol: MRAS
MRAS
0.300 Biomarker group CTD_human New susceptibility locus for coronary artery disease on chromosome 3q22.3. 19198612 2009
Entrez Id: 9332
Gene Symbol: CD163
CD163
0.300 Biomarker group CTD_human Microarray analysis reveals overexpression of CD163 and HO-1 in symptomatic carotid plaques. 17095719 2007
Entrez Id: 356
Gene Symbol: FASLG
FASLG
0.300 Biomarker group CTD_human Decreased circulating Fas ligand in patients with familial combined hyperlipidemia or carotid atherosclerosis: normalization by atorvastatin. 15063428 2004
Entrez Id: 183
Gene Symbol: AGT
AGT
0.300 Biomarker group CTD_human Angiotensinogen gene M235T polymorphism and reduction in wall thickness in response to antihypertensive treatment. 12911327 2003
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
0.300 Therapeutic group CTD_human Predictors of clinical improvement, angiographic recanalization, and intracranial hemorrhage after intra-arterial thrombolysis for acute ischemic stroke. 10512912 1999
Entrez Id: 177
Gene Symbol: AGER
AGER
0.200 Biomarker group RGD Regulation of β-amyloid level in the brain of rats with cerebrovascular hypoperfusion. 21813211 2012
Entrez Id: 1241
Gene Symbol: LTB4R
LTB4R
0.200 Biomarker group RGD Leukotriene B4 signaling through NF-kappaB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia. 16293697 2005
Entrez Id: 5444
Gene Symbol: PON1
PON1
0.070 Biomarker group BEFREE Further studies are required to prospectively assess the role of PON-1 in predicting cerebrovascular events in patients with carotid artery disease. 31626928 2020
Entrez Id: 5444
Gene Symbol: PON1
PON1
0.070 Biomarker group BEFREE The aim of this review is to summarize the characteristics of PON-1, its interactions with drugs and its role in atherosclerosis and especially its relationship with carotid artery disease. 29189170 2019