×
Entrez Id:
324
Gene Symbol:
APC
APC
0.900
GeneticVariation
group
CLINVAR
Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene.
1338904
1992
×
Entrez Id:
324
Gene Symbol:
APC
APC
0.900
GeneticVariation
group
CLINVAR
APC mutations occur early during colorectal tumorigenesis.
1528264
1992
×
Entrez Id:
324
Gene Symbol:
APC
APC
0.900
GeneticVariation
group
CLINVAR
[The effect of occlusion time in the measurement of compliance and resistance of the respiratory system using passive expiration in infants].
2281069
1990
×
Entrez Id:
324
Gene Symbol:
APC
APC
0.900
GeneticVariation
group
CLINVAR
Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors.
8187091
1994
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.500
CausalMutation
group
CLINVAR
Somatic alterations of the DPC4 gene in human colorectal cancers in vivo.
8898652
1996
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.500
CausalMutation
group
CLINVAR
TGF-beta signaling and cancer: structural and functional consequences of mutations in Smads.
9679244
1998
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.500
CausalMutation
group
CLINVAR
Inactivation of both alleles of the DPC4/SMAD4 gene in advanced colorectal cancers: identification of seven novel somatic mutations in tumors from Japanese patients.
10479724
1999
×
Entrez Id:
324
Gene Symbol:
APC
APC
0.900
GeneticVariation
group
CLINVAR
"APC mutations in sporadic colorectal tumors: A mutational ""hotspot"" and interdependence of the ""two hits""."
10737795
2000
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.500
CausalMutation
group
CLINVAR
Transcriptional control by the TGF-beta/Smad signaling system.
10775259
2000
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.500
CausalMutation
group
CLINVAR
Mutations of the BRAF gene in human cancer.
12068308
2002
×
Entrez Id:
324
Gene Symbol:
APC
APC
0.900
GeneticVariation
group
CLINVAR
Mutations of the APC gene in human sporadic colorectal cancers.
12374230
2002
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.500
CausalMutation
group
CLINVAR
Role of Smad4 (DPC4) inactivation in human cancer.
12821112
2003
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.500
CausalMutation
group
CLINVAR
Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells.
14715079
2004
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
0.490
CausalMutation
group
CLINVAR
High frequency of mutations of the PIK3CA gene in human cancers.
15016963
2004
×
Entrez Id:
5728
Gene Symbol:
PTEN
PTEN
0.160
CausalMutation
group
CLINVAR
High frequency of mutations of the PIK3CA gene in human cancers.
15016963
2004
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
0.490
CausalMutation
group
CLINVAR
The PIK3CA gene is mutated with high frequency in human breast cancers.
15254419
2004
×
Entrez Id:
5728
Gene Symbol:
PTEN
PTEN
0.160
CausalMutation
group
CLINVAR
The PIK3CA gene is mutated with high frequency in human breast cancers.
15254419
2004
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
0.490
CausalMutation
group
CLINVAR
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic.
15647370
2005
×
Entrez Id:
5728
Gene Symbol:
PTEN
PTEN
0.160
CausalMutation
group
CLINVAR
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic.
15647370
2005
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
0.490
GeneticVariation
group
CLINVAR
Functional analysis of PIK3CA gene mutations in human colorectal cancer.
15930273
2005
×
Entrez Id:
208
Gene Symbol:
AKT2
AKT2
0.300
GeneticVariation
group
CLINVAR
Colorectal cancer: mutations in a signalling pathway.
16094359
2005
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
0.410
CausalMutation
group
CLINVAR
BRAF mutation predicts sensitivity to MEK inhibition.
16273091
2006
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
0.500
CausalMutation
group
CLINVAR
Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma.
16361624
2005
×
Entrez Id:
3265
Gene Symbol:
HRAS
HRAS
0.200
GeneticVariation
group
CLINVAR
APC inhibits ERK pathway activation and cellular proliferation induced by RAS.
16478791
2006
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
0.500
CausalMutation
group
CLINVAR
KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer.
16618717
2006