Source: CLINVAR ×
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 GeneticVariation group CLINVAR [The effect of occlusion time in the measurement of compliance and resistance of the respiratory system using passive expiration in infants]. 2281069 1990
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 GeneticVariation group CLINVAR APC mutations occur early during colorectal tumorigenesis. 1528264 1992
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 GeneticVariation group CLINVAR Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. 1338904 1992
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 GeneticVariation group CLINVAR Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors. 8187091 1994
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4 		0.500 CausalMutation group CLINVAR Somatic alterations of the DPC4 gene in human colorectal cancers in vivo. 8898652 1996
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4 		0.500 CausalMutation group CLINVAR TGF-beta signaling and cancer: structural and functional consequences of mutations in Smads. 9679244 1998
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4 		0.500 CausalMutation group CLINVAR Inactivation of both alleles of the DPC4/SMAD4 gene in advanced colorectal cancers: identification of seven novel somatic mutations in tumors from Japanese patients. 10479724 1999
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 GeneticVariation group CLINVAR "APC mutations in sporadic colorectal tumors: A mutational ""hotspot"" and interdependence of the ""two hits""." 10737795 2000
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4 		0.500 CausalMutation group CLINVAR Transcriptional control by the TGF-beta/Smad signaling system. 10775259 2000
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 GeneticVariation group CLINVAR Mutations of the APC gene in human sporadic colorectal cancers. 12374230 2002
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Mutations of the BRAF gene in human cancer. 12068308 2002
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4 		0.500 CausalMutation group CLINVAR Role of Smad4 (DPC4) inactivation in human cancer. 12821112 2003
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4 		0.500 CausalMutation group CLINVAR Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells. 14715079 2004
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.490 CausalMutation group CLINVAR The PIK3CA gene is mutated with high frequency in human breast cancers. 15254419 2004
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.490 CausalMutation group CLINVAR High frequency of mutations of the PIK3CA gene in human cancers. 15016963 2004
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.160 CausalMutation group CLINVAR High frequency of mutations of the PIK3CA gene in human cancers. 15016963 2004
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.160 CausalMutation group CLINVAR The PIK3CA gene is mutated with high frequency in human breast cancers. 15254419 2004
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 CausalMutation group CLINVAR Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma. 16361624 2005
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.490 GeneticVariation group CLINVAR Functional analysis of PIK3CA gene mutations in human colorectal cancer. 15930273 2005
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.490 CausalMutation group CLINVAR Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. 15647370 2005
Entrez Id: 208
Gene Symbol: AKT2
AKT2 		0.300 GeneticVariation group CLINVAR Colorectal cancer: mutations in a signalling pathway. 16094359 2005
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.160 CausalMutation group CLINVAR Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. 15647370 2005
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 CausalMutation group CLINVAR KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. 16618717 2006
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.410 CausalMutation group CLINVAR BRAF mutation predicts sensitivity to MEK inhibition. 16273091 2006
Entrez Id: 3265
Gene Symbol: HRAS
HRAS 		0.200 GeneticVariation group CLINVAR APC inhibits ERK pathway activation and cellular proliferation induced by RAS. 16478791 2006