Gene: PTGS2 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group BEFREE Differential expression of matrilysin and cyclooxygenase-2 in intestinal and colorectal neoplasms. 10204802 1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 Biomarker group CTD_human Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. 10485483 1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group BEFREE These data suggest that the LDLr is abnormally regulated in some colorectal tumors and may play a role in the up-regulation of cox-2. 10471521 1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group BEFREE We analyzed and compared expression of the inducible COX-2 isoform in colorectal neoplasms from patients with hereditary nonpolyposis colorectal cancer (HNPCC), familial adenomatous polyposis (FAP), and sporadic CRC. 10419916 1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 PosttranslationalModification group BEFREE Aberrant methylation of the Cyclooxygenase 2 CpG island in colorectal tumors. 10945606 2000
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 Biomarker group CTD_human Rat colorectal tumours treated with a range of non-steroidal anti-inflammatory drugs show altered cyclooxygenase-2 and cyclooxygenase-1 splice variant mRNA expression levels. 11375891 2001
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group LHGDN Modulation of cyclooxygenase-2 expression by APC in HT-29 human colorectal carcinoma cells. 12664576 2002
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group BEFREE The cyclooxygenase-2 (COX-2) gene encodes an inducible enzyme that converts arachidonic acid to prostaglandins and is up-regulated in colorectal neoplasms. 12414664 2002
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group LHGDN The MEK/ERK pathway mediates COX-2-selective NSAID-induced apoptosis and induced COX-2 protein expression in colorectal carcinoma cells. 11992399 2002
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group LHGDN Cyclooxygenase-2 expression correlates with uPAR levels and is responsible for poor prognosis of colorectal cancer. 12405290 2002
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group LHGDN [Relationship between carcinoembryonic antigen and cyclooxygenase 2 expression and colorectal cancer]. 12600292 2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 Biomarker group CTD_human Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein (IAP)-2. 12837940 2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group LHGDN Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-kappa B and I kappa B kinase-alpha in human colorectal cancer epithelial cells. 12771929 2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 Biomarker group BEFREE COX-2, NSAIDs and human neoplasia. Part I: Colorectal neoplasms. 12494894 2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 Biomarker group LHGDN Cyclooxygenase-2 expression and angiogenesis in colorectal cancer. 12800231 2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group LHGDN Expression of cyclooxygenase-2 parallels expression of interleukin-1beta, interleukin-6 and NF-kappaB in human colorectal cancer. 12727794 2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 Biomarker group LHGDN Cyclooxygenase-2 expression in primary human colorectal cancers and bone marrow micrometastases. 15248379 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group LHGDN RNA profiling of cyclooxygenases 1 and 2 in colorectal cancer. 15328521 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group LHGDN Cyclooxygenase-2 activation mediates the proangiogenic effect of nitric oxide in colorectal cancer. 15102673 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group BEFREE In addition, overexpression of COX-2 was found more frequently in colorectal tumors with lymphatic invasion, regional lymph node metastasis and larger size, although without statistical significance. 15075004 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group BEFREE Cyclooxygenase 2 (COX-2) is overexpressed frequently in aerodigestive tumors, especially in colorectal tumors. 15300574 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 Biomarker group LHGDN COX-2 expression and tumor angiogenesis in colorectal cancer. 15285012 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 GeneticVariation group LHGDN Polymorphisms in prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) and risk of colorectal cancer. 15173859 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 Biomarker group CTD_human Prostaglandin E2 enhances intestinal adenoma growth via activation of the Ras-mitogen-activated protein kinase cascade. 15753380 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group BEFREE Overexpression of COX-2 and iNOS mRNA expression was observed in 42.2% and 66.7% of the 90 colorectal tumors, respectively. 15695237 2005