Gene: PTGS2 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 Biomarker group BEFREE COX-2, NSAIDs and human neoplasia. Part I: Colorectal neoplasms. 12494894 2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group BEFREE Cyclooxygenase 2 (COX-2) is overexpressed frequently in aerodigestive tumors, especially in colorectal tumors. 15300574 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group BEFREE COX-2 overexpression is a frequent, but not universal event in colorectal neoplasms. 21158711 2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 PosttranslationalModification group BEFREE Aberrant methylation of the Cyclooxygenase 2 CpG island in colorectal tumors. 10945606 2000
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group LHGDN An upstream CRE-E-box element is essential for gastrin-dependent activation of the cyclooxygenase-2 gene in human colon cancer cells. 17604853 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 GeneticVariation group LHGDN Analysis of K-ras mutations and expression of cyclooxygenase-2 and gastrin protein in laterally spreading tumors. 16174078 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 Biomarker group CTD_human Aspirin use and survival after diagnosis of colorectal cancer. 19671906 2009
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 GeneticVariation group LHGDN Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer. 17151091 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 Biomarker group BEFREE Bioactive metabolites downstream of cyclooxygenase-2 (COX-2) generated prostaglandin H(2) (PGH(2)), in particular prostaglandin E(2) (PGE(2)), are thought to play critical roles during the development of colorectal tumors. 19035518 2009
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group LHGDN Coexpression of VEGF-C and Cox-2 in human colorectal cancer and its association with lymph node metastasis. 16474989 2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 Biomarker group LHGDN Combined analysis of COX-2 and p53 expressions reveals synergistic inverse correlations with microsatellite instability and CpG island methylator phenotype in colorectal cancer. 16820091 2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 Biomarker group LHGDN COX-2 expression and tumor angiogenesis in colorectal cancer. 15285012 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group LHGDN Cyclooxygenase-2 activation mediates the proangiogenic effect of nitric oxide in colorectal cancer. 15102673 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 Biomarker group LHGDN Cyclooxygenase-2 expression and angiogenesis in colorectal cancer. 12800231 2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 Biomarker group CTD_human Cyclooxygenase-2 expression and recurrence of colorectal adenomas: effect of aspirin chemoprevention. 20427397 2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group LHGDN Cyclooxygenase-2 expression correlates with uPAR levels and is responsible for poor prognosis of colorectal cancer. 12405290 2002
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 Biomarker group LHGDN Cyclooxygenase-2 expression in primary human colorectal cancers and bone marrow micrometastases. 15248379 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group LHGDN Detection of colorectal cancer cells from feces using quantitative real-time RT-PCR for colorectal cancer diagnosis. 19016757 2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group BEFREE Differential expression of matrilysin and cyclooxygenase-2 in intestinal and colorectal neoplasms. 10204802 1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group BEFREE Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia. 16818642 2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group LHGDN Expression of cyclooxygenase-2 and its relationship to p53 accumulation in colorectal cancers. 17594159 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group LHGDN Expression of cyclooxygenase-2 parallels expression of interleukin-1beta, interleukin-6 and NF-kappaB in human colorectal cancer. 12727794 2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group BEFREE However, the downstream prostaglandin (PG)-PG receptor pathway involved in these effects is poorly characterized.We studied the PG-pathway in gene expression databases and we found that PTGS2 (prostaglandin G/H synthase and cyclooxygenase) and PTGES (prostaglandin E synthase) are co-expressed in human colorectal tumors. 26498686 2015
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group BEFREE In addition, overexpression of COX-2 was found more frequently in colorectal tumors with lymphatic invasion, regional lymph node metastasis and larger size, although without statistical significance. 15075004 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 Biomarker group CTD_human Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. 10485483 1999