Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 324
Gene Symbol: APC
APC 		0.300 Biomarker group CTD_human The molecular basis of Turcot's syndrome. 7661930 1995
Entrez Id: 351
Gene Symbol: APP
APP 		0.010 GeneticVariation group LHGDN Differential rates of frameshift alterations in four repeat sequences of hereditary nonpolyposis colorectal cancer tumors. 12215842 2002
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.300 Biomarker group CLINGEN The depletion of ATM inhibits colon cancer proliferation and migration via B56γ2-mediated Chk1/p53/CD44 cascades. 28093285 2017
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.300 Biomarker group CLINGEN Downregulated Ku70 and ATM associated to poor prognosis in colorectal cancer among Chinese patients. 25368522 2014
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.300 Biomarker group CLINGEN Cancer Susceptibility Gene Mutations in Individuals With Colorectal Cancer. 28135145 2017
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.300 Biomarker group CLINGEN Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer. 27978560 2017
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.300 Biomarker group CLINGEN Germline mutations in oncogene-induced senescence pathways are associated with multiple sessile serrated adenomas. 24512911 2014
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.300 Biomarker group CLINGEN Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN. 23154512 2012
Entrez Id: 6790
Gene Symbol: AURKA
AURKA 		0.010 GeneticVariation group LHGDN Association between Aurora-A kinase polymorphisms and age of onset of hereditary nonpolyposis colorectal cancer in a Caucasian population. 17219423 2007
Entrez Id: 580
Gene Symbol: BARD1
BARD1 		0.300 Biomarker group CLINGEN Expression of oncogenic BARD1 isoforms affects colon cancer progression and correlates with clinical outcome. 22814582 2012
Entrez Id: 580
Gene Symbol: BARD1
BARD1 		0.300 Biomarker group CLINGEN Expression of an Oncogenic BARD1 Splice Variant Impairs Homologous Recombination and Predicts Response to PARP-1 Inhibitor Therapy in Colon Cancer. 27197561 2016
Entrez Id: 580
Gene Symbol: BARD1
BARD1 		0.300 Biomarker group CLINGEN Adenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1. 11498787 2001
Entrez Id: 580
Gene Symbol: BARD1
BARD1 		0.300 Biomarker group CLINGEN Whole-exome sequencing identifies rare pathogenic variants in new predisposition genes for familial colorectal cancer. 25058500 2015
Entrez Id: 581
Gene Symbol: BAX
BAX 		0.010 GeneticVariation group LHGDN Differential rates of frameshift alterations in four repeat sequences of hereditary nonpolyposis colorectal cancer tumors. 12215842 2002
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.010 GeneticVariation group LHGDN BRAF-V600E is not involved in the colorectal tumorigenesis of HNPCC in patients with functional MLH1 and MSH2 genes. 15782118 2005
Entrez Id: 768
Gene Symbol: CA9
CA9 		0.010 AlteredExpression group LHGDN Carbonic anhydrase IX is highly expressed in hereditary nonpolyposis colorectal cancer. 17855694 2007
Entrez Id: 834
Gene Symbol: CASP1
CASP1 		0.010 GeneticVariation group LHGDN Differential rates of frameshift alterations in four repeat sequences of hereditary nonpolyposis colorectal cancer tumors. 12215842 2002
Entrez Id: 960
Gene Symbol: CD44
CD44 		0.300 Biomarker group CTD_human Functional Genomic mRNA Profiling of Colorectal Adenomas: Identification and in vivo Validation of CD44 and Splice Variant CD44v6 as Molecular Imaging Targets. 28255344 2017
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.300 Biomarker group CLINGEN E-cadherin germline mutations in familial gastric cancer. 9537325 1998
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.300 Biomarker group CLINGEN Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells. 10051639 1999
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.300 Biomarker group CLINGEN Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer. 10072428 1999
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.300 Biomarker group CLINGEN Screening E-cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindred. 11968083 2002
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.300 Biomarker group CLINGEN Loss of CDH1 (E-cadherin) expression is associated with infiltrative tumour growth and lymph node metastasis. 26742007 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.300 Biomarker group CLINGEN Identification of seven novel germline mutations in the human E-cadherin (CDH1) gene. 17221870 2007
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B 		0.300 Biomarker group CLINGEN p27kip1 deficiency impairs G2/M arrest in response to DNA damage, leading to an increase in genetic instability. 17954563 2008