Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B 		0.300 Biomarker group CLINGEN Down-regulation of p27 is associated with development of colorectal adenocarcinoma metastases. 9736017 1998
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B 		0.300 Biomarker group CLINGEN Tumorigenesis in p27/p53- and p18/p53-double null mice: functional collaboration between the pRb and p53 pathways. 15584024 2005
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B 		0.300 Biomarker group CLINGEN Comparative effects of overexpression of p27Kip1 and p21Cip1/Waf1 on growth and differentiation in human colon carcinoma cells. 9926925 1999
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B 		0.300 Biomarker group CLINGEN The murine gene p27Kip1 is haplo-insufficient for tumour suppression. 9823898 1998
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B 		0.300 Biomarker group CLINGEN Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice. 12086850 2002
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B 		0.300 Biomarker group CLINGEN Whole-exome sequencing identifies rare pathogenic variants in new predisposition genes for familial colorectal cancer. 25058500 2015
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B 		0.300 Biomarker group CLINGEN p27kip1 Regulates cdk2 activity in the proliferating zone of the mouse intestinal epithelium: potential role in neoplasia. 17631145 2007
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.300 Biomarker group CLINGEN DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response. 16478982 2006
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.300 Biomarker group CLINGEN The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population. 18996005 2009
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.300 Biomarker group CLINGEN Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells. 24976383 2014
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.300 Biomarker group CLINGEN Homozygosity for a CHEK2*1100delC mutation identified in familial colorectal cancer does not lead to a severe clinical phenotype. 15818573 2005
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.300 Biomarker group CLINGEN DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. 15829956 2005
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.300 Biomarker group CLINGEN Cancer Susceptibility Gene Mutations in Individuals With Colorectal Cancer. 28135145 2017
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.300 Biomarker group CLINGEN Meta-analysis of CHEK2 1100delC variant and colorectal cancer susceptibility. 21807500 2011
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.300 Biomarker group CLINGEN Homozygous inactivation of CHEK2 is linked to a familial case of multiple primary lung cancer with accompanying cancers in other organs. 27900359 2016
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.300 Biomarker group CLINGEN CHEK2 mutations and HNPCC-related colorectal cancer. 19876921 2010
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.300 Biomarker group CLINGEN CHEK2 1100delC is a susceptibility allele for HNPCC-related colorectal cancer. 18676774 2008
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.300 Biomarker group CLINGEN Alterations of Chk1 and Chk2 expression in colon cancer. 18679694 2008
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.300 Biomarker group CLINGEN The CHEK2 1100delC mutation identifies families with a hereditary breast and colorectal cancer phenotype. 12690581 2003
Entrez Id: 1312
Gene Symbol: COMT
COMT 		0.010 GeneticVariation group LHGDN Cytochrome P450 17A1 and catechol O-methyltransferase polymorphisms and age at Lynch syndrome colon cancer onset in Newfoundland. 17606708 2007
Entrez Id: 1495
Gene Symbol: CTNNA1
CTNNA1 		0.300 Biomarker group CLINGEN
Entrez Id: 1586
Gene Symbol: CYP17A1
CYP17A1 		0.010 GeneticVariation group LHGDN Cytochrome P450 17A1 and catechol O-methyltransferase polymorphisms and age at Lynch syndrome colon cancer onset in Newfoundland. 17606708 2007
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1 		0.010 AlteredExpression group LHGDN Genetic variation in genes for the xenobiotic-metabolizing enzymes CYP1A1, EPHX1, GSTM1, GSTT1, and GSTP1 and susceptibility to colorectal cancer in Lynch syndrome. 18768509 2008
Entrez Id: 4072
Gene Symbol: EPCAM
EPCAM 		0.410 CausalMutation group CLINVAR Genomic analysis of an infant with intractable diarrhea and dilated cardiomyopathy. 28701297 2017
Entrez Id: 4072
Gene Symbol: EPCAM
EPCAM 		0.410 GeneticVariation group LHGDN Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1. 19098912 2009