Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9048
Gene Symbol: ARTN
ARTN
0.010 Biomarker phenotype BEFREE To investigate potential sources of heterogeneity of the accuracy of the four-symptom screen between studies including: ART status, CD4 cell count, gestational age, pregnancy stage (pregnancy vs. postpartum), screening test definition of cough (any cough vs. cough greater than 2 weeks).To describe the accuracy of single symptoms included within the four-symptom screen, additioal symptoms or symptom combinations, for identifying active TB in pregnant PLHIV. 29910691 2018
Entrez Id: 6541
Gene Symbol: SLC7A1
SLC7A1
0.010 Biomarker phenotype BEFREE The present study defined CB using CAT 1 and 2 scores and the questions on the severity of cough and sputum from the SGRQ. 29942122 2018
Entrez Id: 28964
Gene Symbol: GIT1
GIT1
0.010 Biomarker phenotype BEFREE The present study defined CB using CAT 1 and 2 scores and the questions on the severity of cough and sputum from the SGRQ. 29942122 2018
Entrez Id: 213
Gene Symbol: ALB
ALB
0.010 Biomarker phenotype BEFREE SBT attempts (odds ratio [OR] = 1.446, 95% confidence interval [CI]: 1.095-1.910), cough peak flow (OR = 0.975, 95% CI: 0.956-0.994) and albumin (OR = 0.847, 95% CI: 0.752-0.954) were independent risk factors for reintubation. 28586526 2018
Entrez Id: 55503
Gene Symbol: TRPV6
TRPV6
0.010 Biomarker phenotype BEFREE The present study defined CB using CAT 1 and 2 scores and the questions on the severity of cough and sputum from the SGRQ. 29942122 2018
Entrez Id: 43
Gene Symbol: ACHE
ACHE
0.010 AlteredExpression phenotype BEFREE Abnormal serum AChE levels associated with pesticide exposure are associated with AChE levels and symptoms such as coughing, being tired, dizziness, and dry skin and irritation. 30047860 2018
Entrez Id: 55
Gene Symbol: ACP3
ACP3
0.010 Biomarker phenotype BEFREE Survival duration (time elapsed from baseline onset until death) is compared on the basis of Bi-PAP initiation threshold (FVC %predict); daily Bi-PAP usage protocol (hours/day); daily cough assist usage (users or non-users); ALS onset type; ALSFRS-R score; and time elapsed from baseline onset until Bi-PAP initiation, using Kruskal-Wallis one-way analysis of variance and Kaplan Meier. 30050497 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.010 Biomarker phenotype BEFREE Intratracheal instillation of IFN-γ enhanced the cough response to citric acid in vivo. 29672123 2018
Entrez Id: 3918
Gene Symbol: LAMC2
LAMC2
0.010 Biomarker phenotype BEFREE A real-time, flow-sensitized pencil-beam MR imaging scan was used to measure CSF stroke volume during rest and immediately following coughing and relaxation periods (total scan time, 90 seconds). 29748208 2018
Entrez Id: 11333
Gene Symbol: PDAP1
PDAP1
0.010 Biomarker phenotype BEFREE Survival duration (time elapsed from baseline onset until death) is compared on the basis of Bi-PAP initiation threshold (FVC %predict); daily Bi-PAP usage protocol (hours/day); daily cough assist usage (users or non-users); ALS onset type; ALSFRS-R score; and time elapsed from baseline onset until Bi-PAP initiation, using Kruskal-Wallis one-way analysis of variance and Kaplan Meier. 30050497 2018
Entrez Id: 8654
Gene Symbol: PDE5A
PDE5A
0.010 Biomarker phenotype BEFREE Selective PDE3, PDE4 and PDE5 inhibitors have demonstrated the most significant cough suppressive effects, confirming their benefits in chronic inflammatory airway diseases associated with bronchoconstriction and cough. 29337269 2018
Entrez Id: 5141
Gene Symbol: PDE4A
PDE4A
0.010 Biomarker phenotype BEFREE Selective PDE3, PDE4 and PDE5 inhibitors have demonstrated the most significant cough suppressive effects, confirming their benefits in chronic inflammatory airway diseases associated with bronchoconstriction and cough. 29337269 2018
Entrez Id: 1384
Gene Symbol: CRAT
CRAT
0.010 Biomarker phenotype BEFREE The present study defined CB using CAT 1 and 2 scores and the questions on the severity of cough and sputum from the SGRQ. 29942122 2018
Entrez Id: 8853
Gene Symbol: ASAP2
ASAP2
0.010 Biomarker phenotype BEFREE Survival duration (time elapsed from baseline onset until death) is compared on the basis of Bi-PAP initiation threshold (FVC %predict); daily Bi-PAP usage protocol (hours/day); daily cough assist usage (users or non-users); ALS onset type; ALSFRS-R score; and time elapsed from baseline onset until Bi-PAP initiation, using Kruskal-Wallis one-way analysis of variance and Kaplan Meier. 30050497 2018
Entrez Id: 181
Gene Symbol: AGRP
AGRP
0.010 Biomarker phenotype BEFREE To investigate potential sources of heterogeneity of the accuracy of the four-symptom screen between studies including: ART status, CD4 cell count, gestational age, pregnancy stage (pregnancy vs. postpartum), screening test definition of cough (any cough vs. cough greater than 2 weeks).To describe the accuracy of single symptoms included within the four-symptom screen, additioal symptoms or symptom combinations, for identifying active TB in pregnant PLHIV. 29910691 2018
Entrez Id: 10884
Gene Symbol: MRPS30
MRPS30
0.010 Biomarker phenotype BEFREE Survival duration (time elapsed from baseline onset until death) is compared on the basis of Bi-PAP initiation threshold (FVC %predict); daily Bi-PAP usage protocol (hours/day); daily cough assist usage (users or non-users); ALS onset type; ALSFRS-R score; and time elapsed from baseline onset until Bi-PAP initiation, using Kruskal-Wallis one-way analysis of variance and Kaplan Meier. 30050497 2018
Entrez Id: 10914
Gene Symbol: PAPOLA
PAPOLA
0.010 Biomarker phenotype BEFREE Survival duration (time elapsed from baseline onset until death) is compared on the basis of Bi-PAP initiation threshold (FVC %predict); daily Bi-PAP usage protocol (hours/day); daily cough assist usage (users or non-users); ALS onset type; ALSFRS-R score; and time elapsed from baseline onset until Bi-PAP initiation, using Kruskal-Wallis one-way analysis of variance and Kaplan Meier. 30050497 2018
Entrez Id: 50807
Gene Symbol: ASAP1
ASAP1
0.010 Biomarker phenotype BEFREE Survival duration (time elapsed from baseline onset until death) is compared on the basis of Bi-PAP initiation threshold (FVC %predict); daily Bi-PAP usage protocol (hours/day); daily cough assist usage (users or non-users); ALS onset type; ALSFRS-R score; and time elapsed from baseline onset until Bi-PAP initiation, using Kruskal-Wallis one-way analysis of variance and Kaplan Meier. 30050497 2018
Entrez Id: 23101
Gene Symbol: MCF2L2
MCF2L2
0.010 Biomarker phenotype BEFREE The sensitization of cough reflex observed in patients with gastroesophageal reflux disease (GERD) is attributed to activation of vagal C-fibers innervating the esophagus by acid, while the heartburn in GERD is mediated by esophageal acid sensitive C-fibers derived from (dorsal root ganglia) DRG. 29597000 2018
Entrez Id: 11334
Gene Symbol: TUSC2
TUSC2
0.010 Biomarker phenotype BEFREE Survival duration (time elapsed from baseline onset until death) is compared on the basis of Bi-PAP initiation threshold (FVC %predict); daily Bi-PAP usage protocol (hours/day); daily cough assist usage (users or non-users); ALS onset type; ALSFRS-R score; and time elapsed from baseline onset until Bi-PAP initiation, using Kruskal-Wallis one-way analysis of variance and Kaplan Meier. 30050497 2018
Entrez Id: 1773
Gene Symbol: DNASE1
DNASE1
0.010 Biomarker phenotype BEFREE Cough was the most common side effect in the mannitol alone arm but there was no occurrence of cough in the dornase alfa alone arm and the most commonly reported reason of withdrawal from the mannitol plus dornase alfa arm was pulmonary exacerbations.In terms of secondary outcomes of the review (pulmonary exacerbations, hospitalisations, symptoms, sputum microbiology), evidence provided by the included studies was more limited. 29424930 2018
Entrez Id: 3
Gene Symbol: A2MP1
A2MP1
0.010 GeneticVariation phenotype BEFREE Rs16918212, located in the alpha-2-macroglobulin pseudogene 1 (A2MP1), was associated with cough in both the identification (odds ratio (OR) = 0.72, p = 5.41 × 10<sup>-5</sup>) and the meta-analyzed replication cohorts (OR = 0.83, p = 0.033). 28073367 2017
Entrez Id: 150094
Gene Symbol: SIK1
SIK1
0.010 Biomarker phenotype BEFREE Present and past MSK pain was the most common self-reported problem in urban areas (34.1%), while it was the third most common self-reported problem in rural areas (15.1%), after abdominal pain and cough. 29077271 2017
Entrez Id: 102724428
Gene Symbol: SIK1B
SIK1B
0.010 Biomarker phenotype BEFREE Present and past MSK pain was the most common self-reported problem in urban areas (34.1%), while it was the third most common self-reported problem in rural areas (15.1%), after abdominal pain and cough. 29077271 2017
Entrez Id: 9311
Gene Symbol: ASIC3
ASIC3
0.010 Biomarker phenotype BEFREE Receptors implicated in cough hypersensitivity are transient receptor potential vanilloid 1 (TRPV1), transient receptor potential cation channel, Subfamily A, Member 1 (TRPA1) and acid sensing ion channel receptor 3 (ASIC3). 28187208 2017