×
Entrez Id:
246778
Gene Symbol:
IL27
IL27
0.170
GeneticVariation
disease
GWASCAT
A Genome-wide Association Study Identifying RAP1A as a Novel Susceptibility Gene for Crohn's Disease in Japanese Individuals.
30500874
2019
×
Entrez Id:
246778
Gene Symbol:
IL27
IL27
0.170
GeneticVariation
disease
GWASCAT
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
26974007
2016
×
Entrez Id:
246778
Gene Symbol:
IL27
IL27
0.170
AlteredExpression
disease
BEFREE
The IL-27 mRNA expression was increased in patients with active CD compared with inactive CD disease (P = 0.035).
27221243
2016
×
Entrez Id:
246778
Gene Symbol:
IL27
IL27
0.170
GeneticVariation
disease
GWASCAT
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
26192919
2015
×
Entrez Id:
246778
Gene Symbol:
IL27
IL27
0.170
GeneticVariation
disease
BEFREE
Association of IL-27 gene three polymorphisms with Crohn's disease susceptibility in a Chinese Han population.
25674271
2014
×
Entrez Id:
246778
Gene Symbol:
IL27
IL27
0.170
Biomarker
disease
BEFREE
Comprehensive epistasis analyses for the known CD susceptibility genes NOD2, IL23R and IL27 were performed.
24223725
2013
×
Entrez Id:
246778
Gene Symbol:
IL27
IL27
0.170
GeneticVariation
disease
BEFREE
We identified a significant enrichment of methylation changes within 50 kb of CD GWAS loci (8.6-fold [P = 0.021] in adults; 2.4-fold [P = 0.009] in adults and children combined), including IL-27 , IL-19, TNF, MST1, and NOD2.
22021194
2012
×
Entrez Id:
246778
Gene Symbol:
IL27
IL27
0.170
Biomarker
disease
BEFREE
IL-27 transcripts are significantly elevated in active Crohn's disease (CD ) but not in ulcerative colitis (UC).
19686419
2009
×
Entrez Id:
246778
Gene Symbol:
IL27
IL27
0.170
Biomarker
disease
BEFREE
IL-1beta, IL-6, IL-12, and IL-27 were higher in affected areas compared to unaffected ones in UC but not CD .
19657406
2009
×
Entrez Id:
246778
Gene Symbol:
IL27
IL27
0.170
AlteredExpression
disease
BEFREE
Notably, increased expression of IL-23 and IL-27 transcripts in CD suggests a T helper 1-dominated immunologic function in this disease.
15674109
2005