Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 260431
Gene Symbol: COPD
COPD
0.100 Biomarker disease BEFREE 49,004 ICU patients were included.ICU length of stay was associated with the development of heart diseases, asthma or COPD and depression. 31715531 2020
Entrez Id: 260431
Gene Symbol: COPD
COPD
0.100 Biomarker disease BEFREE Higher BDI scores were associated with a history of depression (p < 0.001), higher NYHA class (p < 0.001), diabetes (p < 0.001), COPD (p = 0.007), renal disease (p < 0.001) and stroke (p = 0.02). 30929707 2019
Entrez Id: 260431
Gene Symbol: COPD
COPD
0.100 Biomarker disease BEFREE In addition to the functional consequences of dyspnea, which include activity limitation and reduced exercise tolerance, it is important to consider its psychological impact on patients with COPD, such as onset of depression or anxiety. 31213793 2019
Entrez Id: 260431
Gene Symbol: COPD
COPD
0.100 Biomarker disease BEFREE Depressive symptoms were evaluated with the Hospital Anxiety and Depression Scale, and spirometry was performed to screen for COPD. 30942283 2019
Entrez Id: 260431
Gene Symbol: COPD
COPD
0.100 Biomarker disease BEFREE Adequate intake of fruits and vegetables was significantly less likely to be associated with angina, COPD, and asthma; however, it was more than three times more likely to be associated (OR: 3.45; 95% CI: 1.99-5.97) with self-reported depression. 31088447 2019
Entrez Id: 260431
Gene Symbol: COPD
COPD
0.100 Biomarker disease BEFREE Additionally, this audit identified a number of patients with depression or anxiety directly related to their COPD, and it highlighted a trend among this cohort towards more frequent appointments with their General Practitioner, and towards related presentations at the Emergency Department. 31488740 2019
Entrez Id: 260431
Gene Symbol: COPD
COPD
0.100 Biomarker disease BEFREE Symptoms of anxiety and depression and use of anxiolytic-hypnotics and antidepressants in current and former smokers with and without COPD - A cross sectional analysis of the COPDGene cohort. 30782350 2019
Entrez Id: 260431
Gene Symbol: COPD
COPD
0.100 Biomarker disease BEFREE Five multidimensional phenotypes were identified: the MILD COPD characterized by no night-time symptoms and the best health status in terms of quality of life, quality of sleep, level of depression and anxiety, the MILD EMPHYSEMATOUS with prevalent dyspnea in the early-morning and day-time, the SEVERE BRONCHITIC with nocturnal and diurnal cough and phlegm, the SEVERE EMPHYSEMATOUS with nocturnal and diurnal dyspnea and the SEVERE MIXED COPD distinguished by higher frequency of symptoms during 24h and worst quality of life, of sleep and highest levels of depression and anxiety. 31518364 2019
Entrez Id: 260431
Gene Symbol: COPD
COPD
0.100 GeneticVariation disease BEFREE Patients/family-centred outcomes will be dyspnoea (modified Medical Research Council Questionnaire), fatigue (Checklist of individual strength and Functional assessment of chronic illness therapy - fatigue), cough and sputum (Leicester cough questionnaire and Cough and sputum assessment questionnaire), impact of the disease (COPD Assessment Test), emotional state (The Hospital Anxiety and Depression Scale), number of exacerbations, healthcare utilisation, health-related quality of life and family adaptability/cohesion (Family Adaptation and Cohesion Scale). 31151409 2019
Entrez Id: 260431
Gene Symbol: COPD
COPD
0.100 GeneticVariation disease BEFREE Effect of Pulmonary Rehabilitation on Symptoms of Anxiety and Depression in COPD: A Systematic Review and Meta-Analysis. 31034818 2019
Entrez Id: 260431
Gene Symbol: COPD
COPD
0.100 Biomarker disease BEFREE To compare religious coping (RC) in patients with COPD and healthy individuals, as well as to determine whether RC is associated with demographic characteristics, quality of life, depression, and disease severity in the patients with COPD. 31644700 2019
Entrez Id: 260431
Gene Symbol: COPD
COPD
0.100 GeneticVariation disease BEFREE It has been observed that patients with multiple sclerosis (MS), who have psychiatric and physical comorbidities such as depression and COPD, have an increased risk of experiencing more pain. 29491716 2018
Entrez Id: 260431
Gene Symbol: COPD
COPD
0.100 Biomarker disease BEFREE Regularly treated depression may increase use of and adherence to necessary maintenance medications for COPD. 28833488 2018
Entrez Id: 260431
Gene Symbol: COPD
COPD
0.100 Biomarker disease BEFREE PHQ-9 and PHQ-2 fulfill important psychometric criteria (factorial validity, invariance, reliability) for measuring depression in COPD. 29499510 2018
Entrez Id: 260431
Gene Symbol: COPD
COPD
0.100 AlteredExpression disease BEFREE However, cognitive status and, in particular, the level of depression explain a larger percentage of the variance in the CAT scores than the usual COPD clinical severity variables. 29563782 2018
Entrez Id: 260431
Gene Symbol: COPD
COPD
0.100 GeneticVariation disease BEFREE In patients with early COPD, depression was associated with a low quality of life, and female sex, living alone and low income were significant risk factors for depression. 29805257 2018
Entrez Id: 260431
Gene Symbol: COPD
COPD
0.100 GeneticVariation disease BEFREE Through physician-led interviews, data were collected on sociodemographics and disease history, including the impact of COPD on health status using the COPD Assessment Test (CAT); quality of life, using the EuroQol Five-Dimension questionnaire (EQ-5D); and anxiety and depression using the Hospital Anxiety and Depression Scale (HADS). 29731625 2018
Entrez Id: 260431
Gene Symbol: COPD
COPD
0.100 Biomarker disease BEFREE We prospectively enrolled adults with stable COPD who completed the University of Alabama at Birmingham Life Space Assessment (LSA) (range: 0-120, restricted Life-Space mobility: ≤60 and a marker of social isolation in older adults); six-minute walk test (6MWT), and the University of California at San Diego Shortness of Breath Questionnaire, COPD Assessment Test, and Hospital Anxiety and Depression Scale. 30233163 2018
Entrez Id: 260431
Gene Symbol: COPD
COPD
0.100 Biomarker disease BEFREE COPD symptoms such as dyspnea may play an important role in the causal relationship between COPD and depression. 30048834 2018
Entrez Id: 260431
Gene Symbol: COPD
COPD
0.100 GeneticVariation disease BEFREE In smokers with COPD, varenicline and bupropion do not appear to be associated with an increased risk of cardiovascular events, depression or self-harm in comparison with NRT. 28473506 2017
Entrez Id: 260431
Gene Symbol: COPD
COPD
0.100 Biomarker disease BEFREE Patients performed the SPPB, quadriceps muscle strength (QMS), exercise tolerance test (6-min walk test [6MWT]), and pulmonary function; and health-related and psychological factors, physical activity, the COPD assessment test (CAT), body mass index, age, and depression were assessed. 28883721 2017
Entrez Id: 260431
Gene Symbol: COPD
COPD
0.100 GeneticVariation disease BEFREE To determine if the presence of anxiety and depression is associated with a greater risk of frequent exacerbation (≥2 per year) in patients diagnosed with COPD. 27900466 2017
Entrez Id: 260431
Gene Symbol: COPD
COPD
0.100 GeneticVariation disease BEFREE The most common medical problems reported were obesity with body mass index of greater than 30 Kg/m2 (39.1%), hypertension (33.9%), diabetes mellitus (20.8%), depression (4.3%), asthma (17.3%), COPD (6.6%), and hyperlipidemia (2.7%). 28251223 2017
Entrez Id: 260431
Gene Symbol: COPD
COPD
0.100 Biomarker disease BEFREE A possible link between COPD and depression may be irisin, a myokine, expression of which in the skeletal muscle and brain positively correlates with physical activity. 28744117 2017
Entrez Id: 260431
Gene Symbol: COPD
COPD
0.100 Biomarker disease BEFREE Recent evidence supports the effectiveness of psychotherapies that target late-life depression in the context of specific comorbid conditions including COPD, heart failure, Parkinson's disease, stroke and other acute conditions, cognitive impairment, and suicide risk. 28726061 2017