|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that a susceptibility allele for IDDM in the Japanese is more closely associated with the DQA1 gene than the DQB1 gene.
|
1347765 |
1992 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Of the loci on Japanese DR9 haplotypes, the DQA1*0301 allele showed the highest association with IDDM.
|
1358911 |
1992 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our data suggests that a) the DQB1*0502 allele is neutral for IDDM development and b) the susceptibility to IDDM in our DR2-positive patients is related to the compound heterozygous state between the neutral DQA1*0102/DQB1*0502 and the susceptibility DQA1*0501/DQB1*0201 alleles.
|
1412411 |
1992 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Relative contribution of HLA-DQA and -DQB alleles to predisposition to insulin-dependent diabetes mellitus.
|
1429035 |
1992 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Probe-less genomic typing of Arg52 (type 1 diabetes-associated) and non-Arg52 (non-type 1 diabetes-associated) HLA-DQA1 alleles.
|
1472636 |
1992 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In order to investigate the HLA class II associations with IDDM in Algerians, we have used polymerase chain reaction (PCR) and sequence specific oligonucleotide analysis (SSO) to identify DQA1, DQB1, and DRB1 alleles, haplotypes and genotypes in 50 unrelated IDDM patients and 46 controls from a homogeneous population in Western Algeria.
|
1477090 |
1992 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Among Blacks, Caucasoids and Orientals, IDDM susceptibility is associated with some particular combinations of DQA1 and DQB1 genes in cis or trans position.
|
1485949 |
1992 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We simulated DQA1 and DQB1 alleles in 707 consecutively diagnosed IDDM probands and 98 non-diabetic children based on serology, restriction fragment length polymorphism results and sequence data assuming no recombination between DQ and DR.
|
1485950 |
1992 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
DQA1*0102 and *0103), while others are significantly increased in patients with IDDM (i.e.DQA1*0301 and *0501).
|
1502499 |
1992 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These data indicate that DRB1 and DQA1 genes also confer susceptibility to Type 1 diabetes in Japanese.
|
1521722 |
1992 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Complementation of HLA-DQA and -DQB genes confers susceptibility and protection to insulin-dependent diabetes mellitus.
|
1548146 |
1992 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
These data indicate that DQA1 gene confers susceptibility and resistance to Type 1 diabetes in Japanese subjects.
|
1676685 |
1991 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This was in agreement with previously published data in Caucasian and Japanese insulin-dependent diabetes mellitus (IDDM) patients, while the significant increase in the frequency of the DQA1*0501 allele was comparable with that of Caucasian IDDM patients but contrasted with a decrease in this allele in Japanese IDDM patients.
|
1680241 |
1991 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The frequency of certain DRB1-DQA1-DQB1 haplotypes and DQA1-DQB1 genotypes was significantly increased among IDDM patients.
|
1908143 |
1991 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The DQA1 allele A3 was positively associated with IDDM (relative risk [RR] = 25.3, corrected P [Pc] less than 7.0 x 10(-6).
|
2040390 |
1991 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
DNA sequence analysis of major histocompatibility complex (MHC) class II genes from humans and rodents with type 1 (insulin-dependent) diabetes indicates that a portion of MHC-linked genetic susceptibility in humans is determined by the HLA-DQA1 and -DQB1 loci.
|
2187469 |
1990 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The A3 allele of the HLA-DQA1 locus is associated with susceptibility to type 1 diabetes in Japanese.
|
2300572 |
1990 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
This report, based on extensive oligonucleotide dot blot hybridization of PCR-amplified DQA1 and DQB1 genes, reinforces the importance of the Asp57-negative DQ beta chain, but also introduces the possibility that a DQ alpha chain bearing an arginine in position 52 (Arg52) confers susceptibility to IDDM.
|
2318983 |
1990 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
DNA sequencing and oligonucleotide dot-blot analysis of class II genes from two race-specific haplotypes indicate that susceptibility to IDDM is closely linked to the DQA1 locus and suggest that both the DQB1 (ref.
|
2494458 |
1989 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
DQA1 restriction fragment length polymorphisms and insulin-dependent diabetes mellitus: a BglII fragment labels a subset of B8,DR3 haplotypes uniquely associated with insulin-dependent diabetes mellitus.
|
2573591 |
1989 |
|
HLA-DQA1
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Significantly higher mean basal levels of 2'-5' oligoadenylate synthetase activity were associated with HLA-DQA 4.6 phenotype (determined using the restriction enzyme Taq 1 and a DQA probe) and HLA-DR3 (determined serologically), whereas significantly lower mean levels of enzyme activity were associated with HLA-DQA 5.5 and HLA-DR7, in both IDDM and control subjects.
|
2687162 |
1989 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Oligonucleotide probes for HLA-DQA and DQB genes define susceptibility to type 1 (insulin-dependent) diabetes mellitus.
|
3240836 |
1988 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In most cases the data showed this HLA DP allele combination as a part of the HLA DRB1*03-DQA1*0501-DQB1*0201 haplotype positively associated with IDDM, indicating a linkage disequilibrium between the alleles involved in this HLA DR-DQ-DP haplotype and as a consequence, a secondary role of HLA-DP genes in conferring susceptibility to the development of the disease.
|
7576003 |
1995 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Twenty-four unrelated DQA1*0501-DQB1*0201 haplotypes from non-diabetic families had a TAP2B allele frequency (4%) similar to that in IDDM haplotypes.(ABSTRACT TRUNCATED AT 250 WORDS)
|
7589884 |
1995 |