|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, endocrine autoimmunity has a common immunogenetic background; susceptibility is conferred by DQA1*0501 as well as an arginine at position 52 of DQA1 alleles, and protection against IDDM and GD is conferred by DQB1*0602.
|
7608264 |
1995 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Significant protection was encoded by the DRB1*0403 allele, which was observed in 5 of 49 control subjects (10%) and none of 171 IDDM patients (0%) with the DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 genotype (RR = 0.02 [0.01-0.18], P < 0.0005).
|
7729610 |
1995 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, of the five subtypes of DR2, only one, the DRB1*1501, DRB5*0101, DQB1*0602-DQA1*0102 haplotype, was negatively associated with IDDM.
|
7817375 |
1994 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In Japanese, DRB1*0405-DQA1*0301-DQB1*0401, DRB1*0901-DQA1*0301-DQB1*0303 and DRB1*0802-DQA1*0301-DQB1*0302 are the major susceptibility haplotypes to IDDM, while DRB1*1501-DQA1*0102-DQB1*0602 and DRB1*1502-DQA1*0103-DQB1*0601 are the major resistance haplotypes.
|
7859639 |
1994 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Analysis of HLA-DQA1 and -DQB1 genes in Mexican Americans with insulin-dependent diabetes mellitus.
|
7903490 |
1993 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
On the other hand, by PCR-RFLP analysis, DQA1*0301, DQB1*0303 and DQB1*0401 alleles were positively associated with Type 1 diabetes and DQA1*01 was negatively associated with Type 1 diabetes.
|
7903628 |
1994 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
On the other hand, DQA1 and DQB1 genes showed significant association with type 1 diabetes.
|
7911550 |
1994 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The Bgl II RFLP associated with type 1 diabetes in DR3-positive subjects is not due to a DQA1 promoter region polymorphism.
|
7914753 |
1994 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Frequency analysis of HLA-DQA1 and HLA-DQB1 gene alleles and susceptibility to type 1 diabetes mellitus in Russian patients.
|
7949227 |
1994 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Heterozygosis at either residue 57 of DQB1 or residue 52 of DQA1 was sufficient to abrogate statistical significance for disease association, although 47% of IDDM patients were included in these two groups compared with 21% of normal control subjects.
|
7988304 |
1994 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The results show that those DQB1 alleles, which carry non-aspartic acid at position 57, in conjunction with DQA1 alleles carrying arginine at position 52, are strongly associated with susceptibility to type 1 diabetes.
|
8002038 |
1994 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Longitudinal analysis in first degree relatives and other normal controls carrying the DQA1*0301-DQB1*0302 haplotype should assess the hypothesis that IAA qualify as earlier predictive markers for IDDM than high titer ICA.
|
8175975 |
1994 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Heterozygosity either at residue 57 of DQB1 or residue 52 of DQA1 was sufficient to abrogate statistical significance for disease association, although 43.6% of IDDM patients were included in these two groups as compared to 21.6% of normal controls.
|
8183282 |
1994 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Two subsets of HLA-DQA1 alleles mark phenotypic variation in levels of insulin autoantibodies in first degree relatives at risk for insulin-dependent diabetes.
|
8200980 |
1994 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Combinations of specific DRB1, DQA1, DQB1 haplotypes are associated with insulin-dependent diabetes mellitus in Sardinia.
|
8226139 |
1993 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Insulin autoantibodies and high titre islet cell antibodies are preferentially associated with the HLA DQA1*0301-DQB1*0302 haplotype at clinical type 1 (insulin-dependent) diabetes mellitus before age 10 years, but not at onset between age 10 and 40 years. The Belgian Diabetes Registry.
|
8270130 |
1993 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
More important, DQA1*0301 was present among 93% of the patients, and this allele in various transcomplementation combinations with DQB1 alleles showed closer association to IDDM than did any other alleles.
|
8317480 |
1993 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
We conclude that both DQA1 and DQB1 genes are implicated in HLA-associated protection from Type 1 diabetes in this British Caucasian population.
|
8462775 |
1993 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Analysis of two informative families with IDDM demonstrated cosegregation of DQA1 and DQB1 alleles with LST-1 alleles.
|
8547234 |
1995 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the major protective effect for IDDM in the population of Swedish children is conferred by the DR15-DQA1*0102-DQB1*0602 haplotype in a dominant fashion, the DQB1*0602 allele being the allele most likely to be responsible for the protective effect of this haplotype, although an effect of the DR15 allele could not be excluded.
|
8597561 |
1995 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Transcomplementation of HLA DQA1-DQB1 in DR3/DR4 and DR3/DR9 heterozygotes and IDDM in Taiwanese families.
|
8722074 |
1995 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Third, tests of strongest association allowed the following ranking of alleles or haplotypes DQB1*0302-DQA1*0301 (DQ8) > DQB1*0302 > DRB1*0401 > DRB1*0404 and the association of DRB1*0401 has a significant effect in DQ8 positive IDDM patients.
|
8773316 |
1996 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
However, taken together, the data in Senegalese population show that susceptibility and resistance to IDDM are associated both with particular haplotypes and DQA1-DQB1 heterodimers.
|
8773324 |
1996 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
To define genetic susceptibility to insulin-dependent diabetes mellitus each subject was typed in terms of HLA DQA1 and DQB1, and the possible conformation of susceptible heterodimers was considered as a risk marker.
|
8820406 |
1996 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HLA genotyping studies revealed that case 2 carried DRB1*0301-DQA1*0501-DQB*0201/ DRB1*0405-DQA1*0301-DQB1*0302, which was the most susceptible genotype to IDDM in our population.
|
8830330 |
1996 |