Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5617
Gene Symbol: PRL
PRL 		0.320 GeneticVariation group BEFREE The most frequently reported were ADRs related to extrapyramidal syndrome (14.7%), breast disorders or blood prolactin level changes (4.7%), and cardiac arrhythmias (4.6%). 30676073 2019
Entrez Id: 5617
Gene Symbol: PRL
PRL 		0.320 Biomarker group BEFREE Our findings demonstrate that there is moderate to high level of evidence suggesting that in the treatment of schizophrenia, LAI SGAs have higher efficacy and are associated with higher rates of extrapyramidal syndrome and prolactin-related symptoms. 30466208 2018
Entrez Id: 5617
Gene Symbol: PRL
PRL 		0.320 Biomarker group CTD_human Clinical state, plasma levels of haloperidol and prolactin: a correlation study in chronic schizophrenia. 7214106 1980
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.310 Biomarker group CTD_human A common variant in DRD3 gene is associated with risperidone-induced extrapyramidal symptoms. 19506579 2009
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.310 Biomarker group CTD_human Sensitivity of older patients to antipsychotic motor side effects: a PET study examining potential mechanisms. 19225277 2009
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.310 Biomarker group CTD_human Aripiprazole-induced parkinsonism and its association with dopamine and serotonin receptor polymorphisms. 18480698 2008
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.310 GeneticVariation group BEFREE Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients. 16867246 2006
Entrez Id: 1565
Gene Symbol: CYP2D6
CYP2D6 		0.310 Biomarker group CTD_human Delirium resolving upon switching from risperidone to quetiapine: implication of CYP2D6 genotype. 16000684 2005
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.310 Biomarker group CTD_human Prediction and assessment of extrapyramidal side effects induced by risperidone based on dopamine D(2) receptor occupancy. 12211096 2002
Entrez Id: 1565
Gene Symbol: CYP2D6
CYP2D6 		0.310 GeneticVariation group BEFREE Antipsychotic-induced extrapyramidal syndromes and cytochrome P450 2D6 genotype: a case-control study. 11927839 2002
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.310 Biomarker group CTD_human D2 receptor occupancy under recommended and high doses of olanzapine: an iodine-123-iodobenzamide SPECT study. 11198054 2000
Entrez Id: 5155
Gene Symbol: PDGFB
PDGFB 		0.300 Biomarker group CTD_human Mutations in XPR1 cause primary familial brain calcification associated with altered phosphate export. 25938945 2015
Entrez Id: 9213
Gene Symbol: XPR1
XPR1 		0.300 Biomarker group CTD_human Mutations in XPR1 cause primary familial brain calcification associated with altered phosphate export. 25938945 2015
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB 		0.300 Biomarker group CTD_human Mutations in XPR1 cause primary familial brain calcification associated with altered phosphate export. 25938945 2015
Entrez Id: 6575
Gene Symbol: SLC20A2
SLC20A2 		0.300 Biomarker group CTD_human Mutations in XPR1 cause primary familial brain calcification associated with altered phosphate export. 25938945 2015
Entrez Id: 10367
Gene Symbol: MICU1
MICU1 		0.300 Biomarker group CTD_human Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling. 24336167 2014
Entrez Id: 8622
Gene Symbol: PDE8B
PDE8B 		0.300 Biomarker group CTD_human Autosomal-dominant striatal degeneration is caused by a mutation in the phosphodiesterase 8B gene. 20085714 2010
Entrez Id: 1814
Gene Symbol: DRD3
DRD3 		0.300 Biomarker group CTD_human A common variant in DRD3 gene is associated with risperidone-induced extrapyramidal symptoms. 19506579 2009
Entrez Id: 80704
Gene Symbol: SLC19A3
SLC19A3 		0.300 Biomarker group CTD_human Mutations in a thiamine-transporter gene and Wernicke's-like encephalopathy. 19387023 2009
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A 		0.300 Biomarker group CTD_human Aripiprazole-induced parkinsonism and its association with dopamine and serotonin receptor polymorphisms. 18480698 2008
Entrez Id: 151056
Gene Symbol: PLB1
PLB1 		0.010 GeneticVariation group BEFREE Mutations in pantothenate kinase 2 (PANK2) and phospholipase A2 (PLA2G6) cause recessive, childhood-onset extrapyramidal disorders termed pantothenate kinase-associated neurodegeneration (PKAN) and infantile neuroaxonal dystrophy (INAD), respectively. 21496576 2011
Entrez Id: 80025
Gene Symbol: PANK2
PANK2 		0.010 GeneticVariation group BEFREE Mutations in pantothenate kinase 2 (PANK2) and phospholipase A2 (PLA2G6) cause recessive, childhood-onset extrapyramidal disorders termed pantothenate kinase-associated neurodegeneration (PKAN) and infantile neuroaxonal dystrophy (INAD), respectively. 21496576 2011
Entrez Id: 5319
Gene Symbol: PLA2G1B
PLA2G1B 		0.010 GeneticVariation group BEFREE Mutations in pantothenate kinase 2 (PANK2) and phospholipase A2 (PLA2G6) cause recessive, childhood-onset extrapyramidal disorders termed pantothenate kinase-associated neurodegeneration (PKAN) and infantile neuroaxonal dystrophy (INAD), respectively. 21496576 2011
Entrez Id: 8398
Gene Symbol: PLA2G6
PLA2G6 		0.010 GeneticVariation group BEFREE Mutations in pantothenate kinase 2 (PANK2) and phospholipase A2 (PLA2G6) cause recessive, childhood-onset extrapyramidal disorders termed pantothenate kinase-associated neurodegeneration (PKAN) and infantile neuroaxonal dystrophy (INAD), respectively. 21496576 2011
Entrez Id: 7534
Gene Symbol: YWHAZ
YWHAZ 		0.010 GeneticVariation group BEFREE Mutations in pantothenate kinase 2 (PANK2) and phospholipase A2 (PLA2G6) cause recessive, childhood-onset extrapyramidal disorders termed pantothenate kinase-associated neurodegeneration (PKAN) and infantile neuroaxonal dystrophy (INAD), respectively. 21496576 2011