Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2147
Gene Symbol: F2
F2 		0.500 Biomarker phenotype RGD Acute coagulopathy of trauma in the rat. 23481505 2013
Entrez Id: 2147
Gene Symbol: F2
F2 		0.500 Biomarker phenotype RGD Differential effects of TAK-442, a novel orally active direct factor Xa inhibitor, and ximelagatran, a thrombin inhibitor, on factor V-mediated feedback on coagulation cascade and bleeding. 20664909 2010
Entrez Id: 2147
Gene Symbol: F2
F2 		0.500 Biomarker phenotype CTD_human Homozygosity for a novel missense mutation in the prothrombin gene causing a severe bleeding disorder. 7740448 1994
Entrez Id: 1559
Gene Symbol: CYP2C9
CYP2C9 		0.310 Biomarker phenotype CTD_human Those who were carriers of CYP2C9 one-variant haplotypes (*1/*2 or *1/*3) were also found to be associated with the higher risk of bleeding events. 27581200 2016
Entrez Id: 1559
Gene Symbol: CYP2C9
CYP2C9 		0.310 Biomarker phenotype CTD_human The CYP2C9*3 allele may double the risk of major bleeding among patients taking warfarin for 30 or more days. 25521356 2014
Entrez Id: 1559
Gene Symbol: CYP2C9
CYP2C9 		0.310 Biomarker phenotype CTD_human The determination of CYP2C9 and VCORC1 genotypes in patients with APS before warfarin use allows excessive hypocoagulation and related hemorrhages to be avoided. 20597268 2010
Entrez Id: 1559
Gene Symbol: CYP2C9
CYP2C9 		0.310 Biomarker phenotype CTD_human [Cytochrome P4502C9(CYP2C9) gene polymorphism and safety of therapy with warfarin]. 18429757 2008
Entrez Id: 1559
Gene Symbol: CYP2C9
CYP2C9 		0.310 Biomarker phenotype CTD_human Association of CYP2C9 gene polymorphism with bleeding as a complication of warfarin therapy. 18756910 2008
Entrez Id: 1559
Gene Symbol: CYP2C9
CYP2C9 		0.310 GeneticVariation phenotype LHGDN The variant CYP2C9 genotype is associated with an increased risk of major hemorrhage, which persists even after stabilization of therapy. 17653141 2008
Entrez Id: 2155
Gene Symbol: F7
F7 		0.310 AlteredExpression phenotype LHGDN Polymorphisms of the factor VII gene associated with the low activities of vitamin K-dependent coagulation factors in one-month-old infants. 17202767 2007
Entrez Id: 2155
Gene Symbol: F7
F7 		0.310 Therapeutic phenotype CTD_human Recombinant factor VIIa for refractory bleeding after cardiac surgery secondary to anticoagulation with the direct thrombin inhibitor lepirudin. 16553518 2006
Entrez Id: 2155
Gene Symbol: F7
F7 		0.310 Therapeutic phenotype CTD_human Reversal of the International Normalized Ratio with recombinant activated factor VII in central nervous system bleeding during warfarin thromboprophylaxis: clinical and biochemical aspects. 12851533 2003
Entrez Id: 2155
Gene Symbol: F7
F7 		0.310 Therapeutic phenotype CTD_human Successful control of postsurgical bleeding by recombinant factor VIIa in a renal failure patient given low molecular weight heparin and aspirin. 12707733 2003
Entrez Id: 10559
Gene Symbol: SLC35A1
SLC35A1 		0.300 Biomarker phenotype GENOMICS_ENGLAND A mutation in the gene coding for the sialic acid transporter SLC35A1 is required for platelet life span but not proplatelet formation. 30115659 2018
Entrez Id: 2045
Gene Symbol: EPHA7
EPHA7 		0.300 Biomarker phenotype CTD_human Association of Genetic Variants With Warfarin-Associated Bleeding Among Patients of African Descent. 30357299 2018
Entrez Id: 1728
Gene Symbol: NQO1
NQO1 		0.300 Biomarker phenotype CTD_human Patients with the T allele in NQO1*2 (CT or TT genotypes) had a higher risk of bleeding than patients with the CC genotype (adjusted OR: 2.25, 95% CI: 1.37 to 3.70, P=0.001). 27581200 2016
Entrez Id: 79001
Gene Symbol: VKORC1
VKORC1 		0.300 Biomarker phenotype CTD_human The objective was to determine the impact of VKORC1 polymorphisms on warfarin anticoagulant therapy (stable warfarin maintenance dose, time required to reach therapeutic dose and time spent in therapeutic range) and its adverse events (overanticoagulation and bleeding events, time to first overanticoagulation or bleeding event, and therapy for bleeding events) in Croatian patients. 26445138 2015
Entrez Id: 5327
Gene Symbol: PLAT
PLAT 		0.300 Biomarker phenotype CTD_human Fibrin(ogen)-independent role of plasminogen activators in acetaminophen-induced liver injury. 22507835 2012
Entrez Id: 5420
Gene Symbol: PODXL
PODXL 		0.300 Biomarker phenotype CTD_human Diminished thrombogenic responses by deletion of the Podocalyxin Gene in mouse megakaryocytes. 22016802 2011
Entrez Id: 79001
Gene Symbol: VKORC1
VKORC1 		0.300 Biomarker phenotype CTD_human [Recurrent thromboses and hemorrhagic complications in patients with antiphospholipid syndrome during therapy with warfarin plus aspirin]. 20597268 2010
Entrez Id: 83706
Gene Symbol: FERMT3
FERMT3 		0.300 Biomarker phenotype CTD_human As a direct consequence, Kindlin-3 deficiency results in severe bleeding and resistance to arterial thrombosis. 18278053 2008
Entrez Id: 3589
Gene Symbol: IL11
IL11 		0.300 Therapeutic phenotype CTD_human Interleukin-11 attenuates ifosfamide-induced hemorrhagic cystitis. 17980069 2008
Entrez Id: 624
Gene Symbol: BDKRB2
BDKRB2 		0.300 Biomarker phenotype CTD_human Bradykinin B2 receptor knockout mice are protected from thrombosis by increased nitric oxide and prostacyclin. 16514058 2006
Entrez Id: 3690
Gene Symbol: ITGB3
ITGB3 		0.300 Biomarker phenotype CTD_human Prediction of the excessive perioperative bleeding in patients undergoing coronary artery bypass grafting: role of aspirin and platelet glycoprotein IIIa polymorphism. 16153930 2005
Entrez Id: 5328
Gene Symbol: PLAU
PLAU 		0.300 Biomarker phenotype CTD_human Sequential combination of intravenous recombinant tissue plasminogen activator and intra-arterial urokinase in acute ischemic stroke. 15502123 2004