|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
By contrast, the HLA-DPB1 rs3135021 variant was not associated with the outcome of HBV infection, including susceptibility, spontaneously resolved, or disease progression.
|
27051043 |
2016 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association of HLA-DP/DQ and STAT4 polymorphisms with HBV infection outcomes and a mini meta-analysis.
|
25365208 |
2014 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Non-invasive screening of HLA-DPA1 and HLA-DPB1 alleles for persistent hepatitis B virus infection: susceptibility for vertical transmission and toward a personalized approach for vaccination and treatment.
|
21310144 |
2011 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study on chronic HBV infection and its clinical progression in male Han-Taiwanese.
|
24940741 |
2014 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of the HLA-DP gene are associated with the natural clearance of the hepatitis B virus in Asian patients.
|
25109699 |
2014 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, DPB1*04:02 possessing rs1042169 G - rs9277355 C - rs9277356 A is an independent predictor of the HB vaccine response in Koreans.
|
31243853 |
2019 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean.
|
22737229 |
2012 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.
|
19349983 |
2009 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests that HLA-DP/DQ polymorphisms can affect susceptibility and resistance to HBV infection in Chinese populations, and are possibly linked to race and sex.
|
27291710 |
2016 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Japanese patients (202) who were hepatitis B e antigen positive at baseline, received LAM as first-line treatment, and consented to HLA-DP genotyping (HLA-DPA1 rs3077 and HLA-DPB1 rs9277535) were categorized into two cohorts, viz., a cohort who achieved virological response without rescue therapy (cohort 1) and those who did so with rescue therapy (cohort 2).
|
25103089 |
2015 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
By using logistic regression analysis, these two SNPs in the HLA-DPA1 and HLA-DPB1 genes were significantly associated with HBV infection in Han Chinese populations (P = 0.021∼3.36×10(-8) at rs2395309; P = 8.37×10(-3)∼2.68×10(-10) at rs9277535).
|
21904616 |
2011 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population.
|
21750111 |
2011 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our analysis indicated a significant association of rs3077 and rs9277535 in HLA-DP with HBV infection, suggesting that these HLA-DP polymorphisms act beneficially against HBV infection (for rs3077, AG vs. GG: OR = 0.522, 95% CI = 0.485-0.561; AA vs. GG: OR = 0.350, 95% CI = 0.311-0.393; for rs9277535, AG vs. GG: OR = 0.542, 95% CI = 0.506-0.579; AA vs. GG: OR = 0.371, 95% CI = 0.336-0.409).
|
23601003 |
2013 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These results indicate that rs9277535 and rs3077 in HLA-DP are the major determinants of response to hepatitis B vaccine, whereas rs2856718 and rs7453920 in HLA-DQ have little effect on the immune response to hepatitis B vaccine.
|
28882445 |
2017 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A single nucleotide polymorphism in the 3' untranslated region of HLA-DPB1, rs9277534, is associated with HLA-DPB1 expression. rs9277534 has been linked to hepatitis B virus recovery/persistence and the risk of graft-versus-host disease with HLA-DPB1 mismatching transplantation of hematopoietic cells, but its role along with that of HLA-DP expression in AIH have not been fully clarified.
|
30093645 |
2018 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Two single nucleotide polymorphisms (SNP), rs3077 near HLA-DPA1 region and rs9277535 near HLA-DPB1 region, have been shown to be associated with HBV persistence after acute HBV infection.
|
23326374 |
2013 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Examination of large numbers of cohorts revealed that several SNPs in both HLA-DPA1 and HLA-DPB1 loci are associated with persistent HBV infection in Asian populations.
|
24023482 |
2013 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
New loci associated with chronic hepatitis B virus infection in Han Chinese.
|
24162738 |
2013 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To derive a more precise estimation of the relationship between HLA-DP polymorphisms and various outcomes of HBV infection, a meta-analysis of 62,050 subjects from 29 case-control studies was performed.
|
26462556 |
2015 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population.
|
21750111 |
2011 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These results further confirm that genetic variants in the HLA-DP locus are strongly associated with persistent HBV infection in the Han Chinese population.
|
21274863 |
2011 |
|
HLA-DPB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
In sum, we showed, for the first time, that the HLA-DP/DQ clusters contribute independently to HBV infection, and the 3'-UTR region of HLA-DPB1 represents an important functional region involved in HBV infection.
|
26197724 |
2015 |
|
HLA-DPB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
Role of HLA-DP and HLA-DQ on the clearance of hepatitis B virus and the risk of chronic infection in a multiethnic population.
|
28267888 |
2017 |
|
HLA-DPB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
Response to hepatitis B vaccination is co-determined by HLA-DPA1 and -DPB1.
|
31515149 |
2019 |
|
HLA-DPB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
The present findings will serve as a base for future functional studies of HLA-DP molecules in order to understand the pathogenesis of HBV infection and the development of hepatocellular carcinoma.
|
24520320 |
2014 |