|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Host factors including gender, age, family history, HLA-DP, and viral factors including HBV DNA, genotypes, precore mutations, pre-S deletions, and hepatitis B surface antigen (HBsAg) level are associated with the development of these complications.
|
26840752 |
2016 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A recent genome-wide study showed that the single nucleotide polymorphisms (SNPs) in the HLA-DP region were associated with chronic hepatitis B virus (HBV) infection in Japanese and Thai persons.
|
21402545 |
2011 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
By contrast, the HLA-DPB1 rs3135021 variant was not associated with the outcome of HBV infection, including susceptibility, spontaneously resolved, or disease progression.
|
27051043 |
2016 |
|
HLA-DPB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
After transplant, 10 recipients who were positive for HBsAg or with elevation in HBV virus load were regarded as HBV recurrence.No significant association of HLA-DP/DQ polymorphisms with HBV recurrence or transplant etiology was observed (P < .05).
|
28640108 |
2017 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association of HLA-DP/DQ and STAT4 polymorphisms with HBV infection outcomes and a mini meta-analysis.
|
25365208 |
2014 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Non-invasive screening of HLA-DPA1 and HLA-DPB1 alleles for persistent hepatitis B virus infection: susceptibility for vertical transmission and toward a personalized approach for vaccination and treatment.
|
21310144 |
2011 |
|
HLA-DPB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
Identification of the HLA-DPB1 genotypes associated with susceptibility to and protection from CHB infection is essential for future analysis of the mechanisms responsible for immune recognition of hepatitis B virus antigens by HLA-DPB1 molecules.
|
26449183 |
2015 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of the HLA-DP gene are associated with the natural clearance of the hepatitis B virus in Asian patients.
|
25109699 |
2014 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, DPB1*04:02 possessing rs1042169 G - rs9277355 C - rs9277356 A is an independent predictor of the HB vaccine response in Koreans.
|
31243853 |
2019 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests that HLA-DP/DQ polymorphisms can affect susceptibility and resistance to HBV infection in Chinese populations, and are possibly linked to race and sex.
|
27291710 |
2016 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Japanese patients (202) who were hepatitis B e antigen positive at baseline, received LAM as first-line treatment, and consented to HLA-DP genotyping (HLA-DPA1 rs3077 and HLA-DPB1 rs9277535) were categorized into two cohorts, viz., a cohort who achieved virological response without rescue therapy (cohort 1) and those who did so with rescue therapy (cohort 2).
|
25103089 |
2015 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
By using logistic regression analysis, these two SNPs in the HLA-DPA1 and HLA-DPB1 genes were significantly associated with HBV infection in Han Chinese populations (P = 0.021∼3.36×10(-8) at rs2395309; P = 8.37×10(-3)∼2.68×10(-10) at rs9277535).
|
21904616 |
2011 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our analysis indicated a significant association of rs3077 and rs9277535 in HLA-DP with HBV infection, suggesting that these HLA-DP polymorphisms act beneficially against HBV infection (for rs3077, AG vs. GG: OR = 0.522, 95% CI = 0.485-0.561; AA vs. GG: OR = 0.350, 95% CI = 0.311-0.393; for rs9277535, AG vs. GG: OR = 0.542, 95% CI = 0.506-0.579; AA vs. GG: OR = 0.371, 95% CI = 0.336-0.409).
|
23601003 |
2013 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These results indicate that rs9277535 and rs3077 in HLA-DP are the major determinants of response to hepatitis B vaccine, whereas rs2856718 and rs7453920 in HLA-DQ have little effect on the immune response to hepatitis B vaccine.
|
28882445 |
2017 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A single nucleotide polymorphism in the 3' untranslated region of HLA-DPB1, rs9277534, is associated with HLA-DPB1 expression. rs9277534 has been linked to hepatitis B virus recovery/persistence and the risk of graft-versus-host disease with HLA-DPB1 mismatching transplantation of hematopoietic cells, but its role along with that of HLA-DP expression in AIH have not been fully clarified.
|
30093645 |
2018 |
|
HLA-DPB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
These findings highlight the importance of HLA-C and UBE2L3 in the clearance of HBV infection in addition to HLA-DP and HLA-DQ.
|
24162738 |
2013 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Two single nucleotide polymorphisms (SNP), rs3077 near HLA-DPA1 region and rs9277535 near HLA-DPB1 region, have been shown to be associated with HBV persistence after acute HBV infection.
|
23326374 |
2013 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Examination of large numbers of cohorts revealed that several SNPs in both HLA-DPA1 and HLA-DPB1 loci are associated with persistent HBV infection in Asian populations.
|
24023482 |
2013 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To derive a more precise estimation of the relationship between HLA-DP polymorphisms and various outcomes of HBV infection, a meta-analysis of 62,050 subjects from 29 case-control studies was performed.
|
26462556 |
2015 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These results further confirm that genetic variants in the HLA-DP locus are strongly associated with persistent HBV infection in the Han Chinese population.
|
21274863 |
2011 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study identified new variants associated with the risk of chronic hepatitis B.
|
23760081 |
2013 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean.
|
22737229 |
2012 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.
|
19349983 |
2009 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population.
|
21750111 |
2011 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.
|
19349983 |
2009 |