Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.500 GeneticVariation group BEFREE They specifically demonstrate that the influence of ZNRD1 alleles on disease progression rates are attributable to HLA-A10, help clarify the relationship between the HCP5, HLA-C and HLA-B*57 alleles, and reaffirm a critical role of HLA-B*57 alleles in HIV disease. 18982067 2008
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.500 GeneticVariation group BEFREE The various epistatic effects observed here for common, distinct KIR3DL1 and HLA-B Bw4 combinations are unprecedented with regard to any pair of genetic loci in human disease, and indicate that NK cells may have a critical role in the natural history of HIV infection. 17496894 2007
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.500 Biomarker group CTD_human The various epistatic effects observed here for common, distinct KIR3DL1 and HLA-B Bw4 combinations are unprecedented with regard to any pair of genetic loci in human disease, and indicate that NK cells may have a critical role in the natural history of HIV infection. 17496894 2007
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.500 GeneticVariation group BEFREE The compound genotype KIR3DS1/HLA-B Bw4-80I, which presumably favors natural killer cell activation, has been implicated in protection against HIV disease. 16933987 2006
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.500 GeneticVariation group BEFREE CCR5delta32 in the context of untreated HIV disease, or HLA-B*5701 allele on the abacavir hypersensitivity reaction in the context of HAART), it is more likely that HIV disease and treatment outcomes are influenced by a multitude of interacting genotypes and phenotypes, a hypothesis that will become increasingly possible to investigate as improvements in molecular and computational technologies are made. 16848275 2006
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.500 GeneticVariation group LHGDN Long-term nonprogression during acute HIV infection has been strongly associated with HLA-B*5701 or HLA-B*5703. 16081817 2005
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.500 Biomarker group BEFREE HLA-B*5703 seems to be a protective allele against the progression of HIV infection but could influence the increased incidence of SpA observed in this population. 15641063 2005
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.500 Biomarker group BEFREE HLA B*44 is associated with low virus load in human immunodeficiency virus disease, but this association was not evident in this HCV-infected population. 15301865 2004
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.500 GeneticVariation group BEFREE To determine the distribution of HLA-B alleles in the Chinese Yi ethnic group and its association with HIV infection. 15386946 2004
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.500 GeneticVariation group BEFREE Furthermore, HLA-B gene frequencies in the population are those likely to be most influenced by HIV disease, consistent with the observation that B alleles evolve more rapidly than A alleles. 15592417 2004
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.500 GeneticVariation group BEFREE Although the HLA B(*)5701 class I allele is highly overrepresented among human immunodeficiency virus (HIV)-infected long-term nonprogressors (LTNPs), it is also present at the expected frequency (11%) in patients with progressive HIV infection. 12768008 2003
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.500 GeneticVariation group LHGDN Influence of human leukocyte antigen-B22 alleles on the course of human immunodeficiency virus type 1 infection in 3 cohorts of white men. 12964117 2003
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 GeneticVariation group BEFREE Our findings indicate significant association of pro-inflammatory (IL2, IFN-γ, TNF-α) and anti-inflammatory cytokine gene variants (IL4, IL10) with the risk to acquire the HIV infection and development of AIDS related illness in Indian population. 31173933 2019
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 Biomarker group BEFREE The follicular phase of the menstrual cycle was associated with an elevated CCL2 level and retention of resident memory CD4+ T cells, which has implications for increased susceptibility to HIV infection. 30383238 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation group BEFREE IL-10 -819CT genotype was associated with advance HIV disease stage (OR = 0.49, P = 0.045). 31121270 2019
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 Biomarker group BEFREE Dysregulation of IL-2 and IL-7 homeostasis persists in CD4<sup>+</sup>T cell subsets irrespective of presence or absence of viremia or antiretroviral therapy in HIV infection. 30744575 2019
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker group BEFREE However, CD3<sup>+</sup>CD20<sup>+</sup> T cells may also play a protective role in ovarian cancer and HIV infection for their strong propensity to IFN-γ production. 30639700 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.400 GeneticVariation group BEFREE Our findings indicate significant association of pro-inflammatory (IL2, IFN-γ, TNF-α) and anti-inflammatory cytokine gene variants (IL4, IL10) with the risk to acquire the HIV infection and development of AIDS related illness in Indian population. 31173933 2019
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.400 GeneticVariation group BEFREE After adjusting by age, route of HIV infection, length of infection before cART and viral hepatitis coinfection, CCR2 rs1799864-AG genotype was significantly associated with INR status (OR [95% CI]: 1.80 [1.04-3.11]; p = 0.04), and CXCL12 rs1801157-TT genotype showed a trend (OR [95% CI]: 2.47 [0.96-6.35]; p = 0.06). 30921390 2019
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.400 Biomarker group BEFREE We showed that HIV infection significantly reduced the proportion of Th2 (interleukin 4 [IL-4]/IL-5/IL-13) producing <i>M. tuberculosis</i>-specific CD4 T cells and IL-2-producing <i>M. tuberculosis</i>-specific CD4 and CD8 T cells in individuals with LTBI or PTB (<i>P < </i>0.05). 30541853 2019
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 Biomarker group BEFREE In this review, we focus on the distinctive and complementary contributions of CCR5 and CCR2/CCL2 in HIV infection, multiple sclerosis, liver fibrosis and associated hepatocellular carcinoma. 31377844 2019
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 Biomarker group BEFREE Because sICAM1 and CCL2 are associated with an increased risk of HIV-associated neurocognitive disorder, we propose that an established Vpr-ELISA would be useful for monitoring the risk of HIV complications during latent HIV infection. 30938169 2019
Entrez Id: 3811
Gene Symbol: KIR3DL1
KIR3DL1
0.400 Biomarker group BEFREE Past studies on the relationship between Killer cell Immunoglobulin-like Receptor (KIR) and Human Leukocyte Antigen (HLA) genetic variation and chronic immune activation (CIA) in HIV infection are not uniformly consistent. 30614763 2019
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression group BEFREE "Tuberculosis in advanced HIV infection is associated with increased expression of IFNγ and its downstream targets". 29764370 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression group BEFREE HIV infection in ART-naïve women was associated with elevated breast milk levels of IP-10 and MIG, which areTh1-related cytokines induced by IFN-γ. 30359283 2018