Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.110 GeneticVariation phenotype BEFREE We report here the second case of gestational thyrotoxicosis associated with hyperemesis gravidarum due to a mutation of the TSH receptor, providing thyroid hypersensitivity to hCG. 26580241 2016
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.110 Biomarker phenotype HPO
Entrez Id: 57190
Gene Symbol: SELENON
SELENON
0.100 GeneticVariation phenotype CLINVAR
Entrez Id: 9518
Gene Symbol: GDF15
GDF15
0.040 AlteredExpression phenotype BEFREE <b>Results</b> We show GDF15 and IGFBP7 serum levels are significantly increased in women with HG at 12 weeks' gestation. 31000883 2019
Entrez Id: 9518
Gene Symbol: GDF15
GDF15
0.040 GeneticVariation phenotype BEFREE Recent advances in the genetic study of NVP and HG suggest a placental component to the aetiology by implicating common variants in genes encoding placental proteins (namely GDF15 and IGFBP7) and hormone receptors (namely GFRAL and PGR). 31515515 2019
Entrez Id: 9518
Gene Symbol: GDF15
GDF15
0.040 Biomarker phenotype BEFREE Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum. 29563502 2018
Entrez Id: 9518
Gene Symbol: GDF15
GDF15
0.040 AlteredExpression phenotype BEFREE <b>Results</b> Single nucleotide polymorphisms (SNPs) linked to higher levels of GDF15 segregated with disease in HG families. 30258246 2018
Entrez Id: 3490
Gene Symbol: IGFBP7
IGFBP7
0.030 AlteredExpression phenotype BEFREE <b>Results</b> We show GDF15 and IGFBP7 serum levels are significantly increased in women with HG at 12 weeks' gestation. 31000883 2019
Entrez Id: 3490
Gene Symbol: IGFBP7
IGFBP7
0.030 GeneticVariation phenotype BEFREE Recent advances in the genetic study of NVP and HG suggest a placental component to the aetiology by implicating common variants in genes encoding placental proteins (namely GDF15 and IGFBP7) and hormone receptors (namely GFRAL and PGR). 31515515 2019
Entrez Id: 3490
Gene Symbol: IGFBP7
IGFBP7
0.030 GeneticVariation phenotype BEFREE Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum. 29563502 2018
Entrez Id: 389400
Gene Symbol: GFRAL
GFRAL
0.010 GeneticVariation phenotype BEFREE Recent advances in the genetic study of NVP and HG suggest a placental component to the aetiology by implicating common variants in genes encoding placental proteins (namely GDF15 and IGFBP7) and hormone receptors (namely GFRAL and PGR). 31515515 2019
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.010 GeneticVariation phenotype BEFREE Recent advances in the genetic study of NVP and HG suggest a placental component to the aetiology by implicating common variants in genes encoding placental proteins (namely GDF15 and IGFBP7) and hormone receptors (namely GFRAL and PGR). 31515515 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.010 Biomarker phenotype BEFREE The objective of this study was to assess the impact of inflammation in HG pathophysiology and to investigate the association between severity of HG and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and CRP in patients who were admitted to ED with nausea and vomiting. 31118136 2019
Entrez Id: 5741
Gene Symbol: PTH
PTH
0.010 AlteredExpression phenotype BEFREE The HG severity was scored using the Pregnancy-Unique Quantification of Emesis (and nausea) (PUQE).The serum levels of the maternal Ca, parathyroid hormone (PTH), Na, K, blood urea nitrogen(BUN), creatinine, vitamin D(25OHD3), and the maternal urine NTx levels were compared between the groups. 30572827 2018
Entrez Id: 7055
Gene Symbol: THAS
THAS
0.010 Biomarker phenotype BEFREE Serum TAS and TOS values were similar, although oxidative burden in saliva of women with HG were significantly higher than controls. 28347201 2018
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.010 Biomarker phenotype BEFREE These results provide evidence that preeclampsia is associated with a decreased risk of premenopausal and HER2-enriched breast cancer and that hyperemesis, although not associated with breast cancer risk overall, may be associated with raised risk of HER2-enriched tumours. 29516507 2018
Entrez Id: 10282
Gene Symbol: BET1
BET1
0.010 Biomarker phenotype BEFREE BET 1: Haloperidol in cannabinoid hyperemesis syndrome. 30337420 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.010 AlteredExpression phenotype BEFREE Serum suPAR and IL-6 levels proved to be high in the HG group. 29033107 2018
Entrez Id: 6262
Gene Symbol: RYR2
RYR2
0.010 Biomarker phenotype BEFREE Additionally, RYR2 is a downstream drug target of Inderal, used to treat HG and CVS. 27663074 2017
Entrez Id: 6886
Gene Symbol: TAL1
TAL1
0.010 Biomarker phenotype BEFREE In the bivariate analysis, the high rates of HG and high SCL-90-R scores were determined to be related to postpartum depression (p < 0.05). 27418012 2017
Entrez Id: 51540
Gene Symbol: SCLY
SCLY
0.010 Biomarker phenotype BEFREE In the bivariate analysis, the high rates of HG and high SCL-90-R scores were determined to be related to postpartum depression (p < 0.05). 27418012 2017
Entrez Id: 4925
Gene Symbol: NUCB2
NUCB2
0.010 Biomarker phenotype BEFREE The present study was undertaken to investigate the relationship between prealbumin, ghrelin, nesfatin-1 and obestatin concentrations in pregnancies associated with hyperemesis gravidarum. 27235705 2017
Entrez Id: 213
Gene Symbol: ALB
ALB
0.010 Biomarker phenotype BEFREE Hyperemesis gravidarum is associated with increased maternal serum ischemia-modified albumin. 27474836 2017
Entrez Id: 7276
Gene Symbol: TTR
TTR
0.010 Biomarker phenotype BEFREE The present study was undertaken to investigate the relationship between prealbumin, ghrelin, nesfatin-1 and obestatin concentrations in pregnancies associated with hyperemesis gravidarum. 27235705 2017
Entrez Id: 3855
Gene Symbol: KRT7
KRT7
0.010 Biomarker phenotype BEFREE In the bivariate analysis, the high rates of HG and high SCL-90-R scores were determined to be related to postpartum depression (p < 0.05). 27418012 2017