Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 490
Gene Symbol: ATP2B1
ATP2B1
0.700 GeneticVariation group GWASCAT Interaction between Single Nucleotide Polymorphism and Urinary Sodium, Potassium, and Sodium-Potassium Ratio on the Risk of Hypertension in Korean Adults. 28273873 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.700 Therapeutic group CTD_human Our findings suggest that TLR4/MyD88/NF-κB signaling and PPAR-γ within the PVN are involved in the beneficial effects of telmisartan in hypertension. 27292124 2016
Entrez Id: 490
Gene Symbol: ATP2B1
ATP2B1
0.700 GeneticVariation group BEFREE Interaction according to urinary sodium excretion level on the association between ATP2B1 rs17249754 and incident hypertension: the Korean genome epidemiology study. 27149052 2016
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.700 Therapeutic group CTD_human TLR4/MyD88/NF-κB signaling and PPAR-γ within the paraventricular nucleus are involved in the effects of telmisartan in hypertension. 27292124 2016
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.700 GeneticVariation group BEFREE We recommend determination of the 24-h urinary free cortisol excretion and sequencing of the NR3C1 gene in patients with hyperandrogenism and/or hypertension of unknown origin. 25715669 2016
Entrez Id: 490
Gene Symbol: ATP2B1
ATP2B1
0.700 GeneticVariation group BEFREE Crossover analysis and stratified analysis indicated that BMI has a major effect on the development of hypertension, while ATP2B1 variants have a minor effect. 26933664 2016
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.700 Biomarker group CTD_human Our findings suggest that TLR4/MyD88/NF-κB signaling and PPAR-γ within the PVN are involved in the beneficial effects of telmisartan in hypertension. 27292124 2016
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.700 Biomarker group CTD_human TLR4/MyD88/NF-κB signaling and PPAR-γ within the paraventricular nucleus are involved in the effects of telmisartan in hypertension. 27292124 2016
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.700 Biomarker group CTD_human In this study, we determined whether AT1-R antagonist telmisartan within the hypothalamic paraventricular nucleus (PVN) attenuates hypertension and hypothalamic inflammation via both the TLR4/MyD88/NF-κB signaling pathway and peroxisome proliferator-activated receptor-γ (PPAR-γ) in the PVN in hypertensive rats. 27292124 2016
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.700 Therapeutic group CTD_human In this study, we determined whether AT1-R antagonist telmisartan within the hypothalamic paraventricular nucleus (PVN) attenuates hypertension and hypothalamic inflammation via both the TLR4/MyD88/NF-κB signaling pathway and peroxisome proliferator-activated receptor-γ (PPAR-γ) in the PVN in hypertensive rats. 27292124 2016
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2
0.700 Biomarker group BEFREE However, the serum F/E ratio was associated with BP, suggesting a role of 11βHSD2 in mineralocorticoid hypertension. 25907225 2016
Entrez Id: 490
Gene Symbol: ATP2B1
ATP2B1
0.700 GeneticVariation group BEFREE The present study confirmed the significant association of ATP2B1 rs17249754 with risk of hypertension among Chinese children, but failed to replicate the association of CSK rs1378942, MTHFR rs1801133, CYP17A1 rs1004467, STK39 rs3754777 and FGF5 rs16998073 with BP/risk of hypertension. 23759979 2015
Entrez Id: 490
Gene Symbol: ATP2B1
ATP2B1
0.700 GeneticVariation group GWASCAT Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension. 25249183 2015
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2
0.700 AlteredExpression group BEFREE Post-translational histone methylation at different histone 3 lysine residues was also observed to control the expression of genes related to AH as lysine-specific demethylase-1(LSD1), HSD11B2, and epithelial sodium channel subunit α (SCNN1A). 25035152 2015
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.700 Biomarker group BEFREE Importantly, GR agonist significantly increased blood pressure and redox markers in TG mice with Hap-6A of the hAGT gene. 25568318 2015
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2
0.700 Biomarker group BEFREE The hypertension phenotype is also epigenetically modulated by HSD11B2 methylation in subjects heterozygous for the mutation. 26126204 2015
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2
0.700 AlteredExpression group BEFREE The isozyme 11beta-HSD2 is selectively expressed in mineralocorticoid target tissues and its activity is reduced in various disease states with abnormal sodium retention and hypertension, including the apparent mineralocorticoid excess. 25133511 2015
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2
0.700 AlteredExpression group BEFREE To gain insight into potentially relevant miRNAs in vivo, we investigated 2 models with differential 11β-HSD2 activity linked with salt-sensitive hypertension. 24980668 2014
Entrez Id: 490
Gene Symbol: ATP2B1
ATP2B1
0.700 GeneticVariation group BEFREE Five gene variants, rs11066280 (C12orf51), rs12229654 and rs3782889 (MYL2), rs2072134 (OAS3), rs2093395 (TREML2), and rs17249754 (ATP2B1), were found to be associated with hypertension mostly in men (P = 4.76 × 10(-14) to 4.46 × 10(-7) in the joint analysis); three SNPs (rs11066280, rs12229654, and rs3782889) remained significant after Bonferroni correction in an independent population. 24142389 2014
Entrez Id: 490
Gene Symbol: ATP2B1
ATP2B1
0.700 Biomarker group BEFREE Moreover, vascular smooth muscle cell ATP2B1 knockout mice exhibited high blood pressure in radio telemetry-based experiments. 23324996 2013
Entrez Id: 490
Gene Symbol: ATP2B1
ATP2B1
0.700 GeneticVariation group BEFREE Common variants in the ATP2B1 gene are associated with hypertension and arterial stiffness in Chinese population. 23079715 2013
Entrez Id: 490
Gene Symbol: ATP2B1
ATP2B1
0.700 GeneticVariation group BEFREE Besides chr9p21 and COL4A1, known loci for CHD, these included SNPs having reported genome-wide association study association with hypertension (e.g., ATP2B1). 23727086 2013
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.700 GeneticVariation group BEFREE Peroxisome proliferator-activated receptor-γ mutations responsible for lipodystrophy with severe hypertension activate the cellular renin-angiotensin system. 23393388 2013
Entrez Id: 490
Gene Symbol: ATP2B1
ATP2B1
0.700 GeneticVariation group BEFREE We also observed a significant association of 4 SNPs and the GRS with hypertension (ATP2B1 rs17249754: P = 0.02; CSK rs1378942: P = 0.02; CYP17A1 rs1004467: P = 0.02; MTHFR rs1801133: P = 0.03; GRS: P = 0.0004). 23591986 2013
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.700 GeneticVariation group BEFREE Mutations in NR3C1 do not seem to be common causes for hypertension with low renin and aldosterone levels. 23076843 2013