Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 959
Gene Symbol: CD40LG
CD40LG 		0.500 Biomarker phenotype CTD_human (1) Patients with primary (n=13) and secondary (n=11) PAH but not those with chronic thromboembolic pulmonary hypertension (n=8) had increased plasma levels of soluble (s) CD40L compared with control subjects (n=8). 15302794 2004
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B 		0.200 Therapeutic phenotype RGD 17β-Estradiol attenuates hypoxic pulmonary hypertension via estrogen receptor-mediated effects. 22383500 2012
Entrez Id: 659
Gene Symbol: BMPR2
BMPR2 		0.370 Biomarker phenotype CTD_human BMPR2 germline mutations in pulmonary hypertension associated with fenfluramine derivatives. 12358323 2002
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.320 GeneticVariation phenotype LHGDN Angiotensin-converting enzyme DD genotype in patients with primary pulmonary hypertension: increased frequency and association with preserved haemodynamics. 12692750 2003
Entrez Id: 5468
Gene Symbol: PPARG
PPARG 		0.030 AlteredExpression phenotype LHGDN Peroxisome proliferator-activated receptor gamma (PPARgamma) expression is decreased in pulmonary hypertension and affects endothelial cell growth. 12714563 2003
Entrez Id: 659
Gene Symbol: BMPR2
BMPR2 		0.370 GeneticVariation phenotype LHGDN BMPR2 mutations have short lifetime expectancy in primary pulmonary hypertension. 15965979 2005
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA 		0.010 Biomarker phenotype LHGDN Vascular endothelial growth factor, lipoporotein-associated phospholipase A2, sP-selectin and antiphospholipid antibodies, biological markers with prognostic value in pulmonary hypertension associated with chronic obstructive pulmonary disease and systemic lupus erithematosus. 17509958 2007
Entrez Id: 659
Gene Symbol: BMPR2
BMPR2 		0.370 GeneticVariation phenotype LHGDN A novel mutation in the BMPR2 gene in familial pulmonary arterial hypertension. 18364108 2008
Entrez Id: 5970
Gene Symbol: RELA
RELA 		0.200 Biomarker phenotype RGD A nuclear factor-kappaB inhibitor pyrrolidine dithiocarbamate ameliorates pulmonary hypertension in rats. 17934115 2007
Entrez Id: 659
Gene Symbol: BMPR2
BMPR2 		0.370 Biomarker phenotype CTD_human Abnormal trafficking of endogenously expressed BMPR2 mutant allelic products in patients with heritable pulmonary arterial hypertension. 24224048 2013
Entrez Id: 55512
Gene Symbol: SMPD3
SMPD3 		0.200 Therapeutic phenotype RGD Activation of neutral sphingomyelinase is involved in acute hypoxic pulmonary vasoconstriction. 19088082 2009
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A 		0.200 Therapeutic phenotype RGD Activation of PPAR-γ ameliorates pulmonary arterial hypertension via inducing heme oxygenase-1 and p21(WAF1): an in vivo study in rats. 24412385 2014
Entrez Id: 1909
Gene Symbol: EDNRA
EDNRA 		0.200 Biomarker phenotype RGD Aiming at developing new endothelin-A receptor (ETA) antagonist for treatment of pulmonary hypertension, di-n-butylaminocarbamyl-L-leucyl-D-tryptophanyl-D-4-chloro-Phe, named GF063, was synthesized at base of selective ETA receptor antagonist BQ485 and selected for the further pharmacological characterization. 20531217 2010
Entrez Id: 650
Gene Symbol: BMP2
BMP2 		0.020 Biomarker phenotype LHGDN An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension. 18382765 2008
Entrez Id: 5468
Gene Symbol: PPARG
PPARG 		0.030 Biomarker phenotype LHGDN An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension. 18382765 2008
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.010 Biomarker phenotype LHGDN An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension. 18382765 2008
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.210 Biomarker phenotype RGD Ang-(1-7) might prevent the development of monocrotaline induced pulmonary arterial hypertension in rats. 21381494 2011
Entrez Id: 284
Gene Symbol: ANGPT1
ANGPT1 		0.210 Biomarker phenotype LHGDN Angiopoietin/Tie2 pathway influences smooth muscle hyperplasia in idiopathic pulmonary hypertension. 16917117 2006
Entrez Id: 2152
Gene Symbol: F3
F3 		0.010 AlteredExpression phenotype LHGDN As enhanced NFkappaB activity has been observed in patients with pulmonary hypertension, Rac-dependent activation of the NFkappaB pathway may be a critical element promoting thrombin-induced TF expression and activity, and thus a prothrombotic state in pulmonary hypertension. 15242552 2004
Entrez Id: 3105
Gene Symbol: HLA-A
HLA-A 		0.010 GeneticVariation phenotype LHGDN Association of clinical features with HLA in chronic pulmonary thromboembolism. 15640334 2005
Entrez Id: 4878
Gene Symbol: NPPA
NPPA 		0.200 Biomarker phenotype RGD Atrial natriuretic peptide attenuates the development of pulmonary hypertension in rats adapted to chronic hypoxia. 2136863 1990
Entrez Id: 4879
Gene Symbol: NPPB
NPPB 		0.530 Biomarker phenotype CTD_human Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: role of protein kinase G nitration. 21351102 2011
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR 		0.200 Biomarker phenotype RGD Attenuation of chronic hypoxic pulmonary hypertension by simvastatin. 12750068 2003
Entrez Id: 3778
Gene Symbol: KCNMA1
KCNMA1 		0.300 Biomarker phenotype CTD_human BK channels in rat and human pulmonary smooth muscle cells are BKα-β1 functional complexes lacking the oxygen-sensitive stress axis regulated exon insert. 28090300 2016
Entrez Id: 659
Gene Symbol: BMPR2
BMPR2 		0.370 Biomarker phenotype LHGDN BMP4 inhibits proliferation and promotes myocyte differentiation of lung fibroblasts via Smad1 and JNK pathways. 15516492 2005