Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 941
Gene Symbol: CD80
CD80 		0.010 AlteredExpression disease BEFREE The expression of CD11C+CD80+ and CD11c+TIM3+ in intestinal LPDCs in mice with IBS increased significantly. 31576093 2019
Entrez Id: 79671
Gene Symbol: NLRX1
NLRX1 		0.010 Biomarker disease BEFREE Exploratory studies with NX-13: oral toxicity and pharmacokinetics in rodents of an orally active, gut-restricted first-in-class therapeutic for IBD that targets NLRX1. 31650868 2019
Entrez Id: 2903
Gene Symbol: GRIN2A
GRIN2A 		0.010 Biomarker disease BEFREE The IBS rat's abdomen is more sensitive and irritable; NR1, NR2A, and NR2B in ACC and NR1 and NR2B in colon of rats significantly increased in the model group versus the normal group (P<0.01) and were inhibited in all treatment groups (P<0.01, P<0.05). 30854008 2019
Entrez Id: 7439
Gene Symbol: BEST1
BEST1 		0.010 Biomarker disease BEFREE Abbreviations: AGA: anti-gliadin antibodies; Anti-DGP-ab: anti-deamidated gliadin peptide antibodies; Anti-tTG-ab: anti-tissue transglutaminase antibodies; ATD: auto-immune thyroid disorders; BMD: bone mineral density; CD: coeliac disease; DH: dermatitis herpetiformis; EMA: anti-endomysial antibodies; FDR: first-degree relatives; GFD: gluten-free diet; HbA1c: haemoglobin A1c; HLA: human leucocyte antigen; IBS: irritable bowel syndrome; LMIC: low- and middle-income countries; NPV: negative predictive value; NRCD: non-responsive coeliac disease; POCT: point-of-care tests; SDR: second-degree relatives; SIBO: small intestinal bacterial overgrowth; T1DM: type 1 diabetes mellitus; ULN: upper limit of normal. 30099930 2019
Entrez Id: 129521
Gene Symbol: NMS
NMS 		0.010 Biomarker disease BEFREE <b>Abbreviations</b>: 5-HT: 5-hydroxytryptamine/serotonin; BDNF: brain-derived neurotrophic factor; CRF: corticotrophin-releasing factor; EC: enterochromaffin; ENS: enteric nervous system; GI: gastrointestinal; GPCR: G-protein-coupled receptor; IBS (-D): irritable bowel syndrome (diarrhea predominant); LRP5/6: low-density lipoprotein receptor-related protein 5/6; MAPK: mitogen-activated protein kinase; NGF: nerve growth factor; NMS: neonatal-maternal separation; PI3K: phosphoinositode3-kinase; PLCγ: phospholipase c, gamma subtype; TrkA: tropomyosin receptor kinase A. 31272268 2019
Entrez Id: 2735
Gene Symbol: GLI1
GLI1 		0.010 GeneticVariation disease BEFREE A single-nucleotide polymorphism prevented Gli binding and showed association with irritable bowel syndrome. 30802137 2019
Entrez Id: 151
Gene Symbol: ADRA2B
ADRA2B 		0.010 Biomarker disease BEFREE <b>Abbreviations</b>: 5-HT: 5-hydroxytryptamine/serotonin; BDNF: brain-derived neurotrophic factor; CRF: corticotrophin-releasing factor; EC: enterochromaffin; ENS: enteric nervous system; GI: gastrointestinal; GPCR: G-protein-coupled receptor; IBS (-D): irritable bowel syndrome (diarrhea predominant); LRP5/6: low-density lipoprotein receptor-related protein 5/6; MAPK: mitogen-activated protein kinase; NGF: nerve growth factor; NMS: neonatal-maternal separation; PI3K: phosphoinositode3-kinase; PLCγ: phospholipase c, gamma subtype; TrkA: tropomyosin receptor kinase A. 31272268 2019
Entrez Id: 1909
Gene Symbol: EDNRA
EDNRA 		0.010 Biomarker disease BEFREE <b>Abbreviations</b>: 5-HT: 5-hydroxytryptamine/serotonin; BDNF: brain-derived neurotrophic factor; CRF: corticotrophin-releasing factor; EC: enterochromaffin; ENS: enteric nervous system; GI: gastrointestinal; GPCR: G-protein-coupled receptor; IBS (-D): irritable bowel syndrome (diarrhea predominant); LRP5/6: low-density lipoprotein receptor-related protein 5/6; MAPK: mitogen-activated protein kinase; NGF: nerve growth factor; NMS: neonatal-maternal separation; PI3K: phosphoinositode3-kinase; PLCγ: phospholipase c, gamma subtype; TrkA: tropomyosin receptor kinase A. 31272268 2019
Entrez Id: 80781
Gene Symbol: COL18A1
COL18A1 		0.010 AlteredExpression disease BEFREE Mean H-scores for endostatin expression were higher in the active UC group than in the inactive UC and IBS groups, in the stroma and endothelium. 30892485 2019
Entrez Id: 9170
Gene Symbol: LPAR2
LPAR2 		0.010 Biomarker disease BEFREE <b>Abbreviations</b>: 5-HT: 5-hydroxytryptamine/serotonin; BDNF: brain-derived neurotrophic factor; CRF: corticotrophin-releasing factor; EC: enterochromaffin; ENS: enteric nervous system; GI: gastrointestinal; GPCR: G-protein-coupled receptor; IBS (-D): irritable bowel syndrome (diarrhea predominant); LRP5/6: low-density lipoprotein receptor-related protein 5/6; MAPK: mitogen-activated protein kinase; NGF: nerve growth factor; NMS: neonatal-maternal separation; PI3K: phosphoinositode3-kinase; PLCγ: phospholipase c, gamma subtype; TrkA: tropomyosin receptor kinase A. 31272268 2019
Entrez Id: 148
Gene Symbol: ADRA1A
ADRA1A 		0.010 Biomarker disease BEFREE <b>Abbreviations</b>: 5-HT: 5-hydroxytryptamine/serotonin; BDNF: brain-derived neurotrophic factor; CRF: corticotrophin-releasing factor; EC: enterochromaffin; ENS: enteric nervous system; GI: gastrointestinal; GPCR: G-protein-coupled receptor; IBS (-D): irritable bowel syndrome (diarrhea predominant); LRP5/6: low-density lipoprotein receptor-related protein 5/6; MAPK: mitogen-activated protein kinase; NGF: nerve growth factor; NMS: neonatal-maternal separation; PI3K: phosphoinositode3-kinase; PLCγ: phospholipase c, gamma subtype; TrkA: tropomyosin receptor kinase A. 31272268 2019
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA 		0.010 AlteredExpression disease BEFREE Mean H-scores for VEGF expression were higher in the active UC group than in the inactive UC and IBS groups, in the stroma, endothelium and epithelium. 30892485 2019
Entrez Id: 107
Gene Symbol: ADCY1
ADCY1 		0.010 Biomarker disease BEFREE We found that AC1, a key enzyme for pain-related cortical plasticity, was significantly increased in the ACC in an animal model of irritable bowel syndrome. 31665810 2019
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ 		0.010 Biomarker disease BEFREE Chemerin was higher in IBS-D compared with both IBS-C and IBS-A, while apelin and adiponectin were not different between subtypes. 31306342 2019
Entrez Id: 100653366
Gene Symbol: PSC
PSC 		0.010 Biomarker disease BEFREE Our aim was to determine the clinical characteristics and management of PSC in IBD patients, and the factors associated with malignancies. 31063540 2019
Entrez Id: 28982
Gene Symbol: FLVCR1
FLVCR1 		0.010 Biomarker disease BEFREE Patients with IBS (Rome III criteria), thoroughly characterized regarding pathophysiology (colonic transit time, visceral sensitivity, and autonomic nervous system [ANS] function), symptom profile (IBS severity, somatic symptoms, gastrointestinal [GI]-specific anxiety and fatigue), and quality of life, were explored for differences regarding pathophysiology and symptoms between patients with and without reported psychological distress in univariate and multivariate analyses (Principal Component Analysis [PCA] with Hotelling's T<sup>2</sup> and Orthogonal Partial Least Squares-Discriminant Analysis [OPLS-DA]). 31056802 2019
Entrez Id: 51182
Gene Symbol: HSPA14
HSPA14 		0.010 Biomarker disease BEFREE Hsp60 as a Novel Target in IBD Management: A Prospect. 30800066 2019
Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2 		0.010 Biomarker disease BEFREE In conclusion, ephrinB2/ephB2 promoted the synaptic sprouting and potentiation of myenteric nerves involved in persistent muscle hypercontractility and pain in PI-IBS. 31601124 2019
Entrez Id: 8322
Gene Symbol: FZD4
FZD4 		0.010 Biomarker disease BEFREE <b>Abbreviations</b>: 5-HT: 5-hydroxytryptamine/serotonin; BDNF: brain-derived neurotrophic factor; CRF: corticotrophin-releasing factor; EC: enterochromaffin; ENS: enteric nervous system; GI: gastrointestinal; GPCR: G-protein-coupled receptor; IBS (-D): irritable bowel syndrome (diarrhea predominant); LRP5/6: low-density lipoprotein receptor-related protein 5/6; MAPK: mitogen-activated protein kinase; NGF: nerve growth factor; NMS: neonatal-maternal separation; PI3K: phosphoinositode3-kinase; PLCγ: phospholipase c, gamma subtype; TrkA: tropomyosin receptor kinase A. 31272268 2019
Entrez Id: 23705
Gene Symbol: CADM1
CADM1 		0.010 Biomarker disease BEFREE In conclusion, CADM1 is necessary and sufficient to drive mast cell-sensory neuron adhesion and promote the development of a microenvironment in which neurons enhance mast cell responsiveness to antigen, this interaction could explain why the incidence of painful neuroinflammatory disorders such as irritable bowel syndrome (IBS) are increased in atopic patients. 31275114 2019
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG 		0.010 Biomarker disease BEFREE <b>Abbreviations</b>: 5-HT: 5-hydroxytryptamine/serotonin; BDNF: brain-derived neurotrophic factor; CRF: corticotrophin-releasing factor; EC: enterochromaffin; ENS: enteric nervous system; GI: gastrointestinal; GPCR: G-protein-coupled receptor; IBS (-D): irritable bowel syndrome (diarrhea predominant); LRP5/6: low-density lipoprotein receptor-related protein 5/6; MAPK: mitogen-activated protein kinase; NGF: nerve growth factor; NMS: neonatal-maternal separation; PI3K: phosphoinositode3-kinase; PLCγ: phospholipase c, gamma subtype; TrkA: tropomyosin receptor kinase A. 31272268 2019
Entrez Id: 149992
Gene Symbol: ANKRD30BP2
ANKRD30BP2 		0.010 Biomarker disease BEFREE By revealing various sequence types in the widespread Ct85-cluster and their distribution, the results improve our understanding of these uncultured bacteria, which is essential for future efforts to cultivate representatives of the Ct85-cluster and reveal their roles in IBS. 31562947 2019
Entrez Id: 10537
Gene Symbol: UBD
UBD 		0.010 AlteredExpression disease BEFREE Notably, post-infliximab [IFX] downregulation of UBD reflected favourable outcome in IBD patients. 30395194 2019
Entrez Id: 790
Gene Symbol: CAD
CAD 		0.010 Biomarker disease BEFREE Multivariate Cox proportional hazards analysis identified older age (age, 51-65 years; aHR, 1.67; 95% CI, 1.09-2.56; and age > 65; aHR, 1.59; 95% CI, 1.02-2.48), hypothyroidism (aHR, 4.24; 95% CI, 1.92-9.37), CAD (aHR, 1.70; 95% CI, 1.17-2.48), and depression (aHR, 3.15; 95% CI, 2.14-4.64) as independent RLS risk factors in IBS patients. 31369638 2019
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		0.010 Biomarker disease BEFREE <b>Abbreviations</b>: 5-HT: 5-hydroxytryptamine/serotonin; BDNF: brain-derived neurotrophic factor; CRF: corticotrophin-releasing factor; EC: enterochromaffin; ENS: enteric nervous system; GI: gastrointestinal; GPCR: G-protein-coupled receptor; IBS (-D): irritable bowel syndrome (diarrhea predominant); LRP5/6: low-density lipoprotein receptor-related protein 5/6; MAPK: mitogen-activated protein kinase; NGF: nerve growth factor; NMS: neonatal-maternal separation; PI3K: phosphoinositode3-kinase; PLCγ: phospholipase c, gamma subtype; TrkA: tropomyosin receptor kinase A. 31272268 2019