Gene: JAK2 ×
Source: CLINVAR ×
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3717
Gene Symbol: JAK2
JAK2 		0.800 GeneticVariation disease CLINVAR Proliferation and survival signaling from both Jak2-V617F and Lyn involving GSK3 and mTOR/p70S6K/4EBP1 in PVTL-1 cell line newly established from acute myeloid leukemia transformed from polycythemia vera. 24404189 2014
Entrez Id: 3717
Gene Symbol: JAK2
JAK2 		0.800 GeneticVariation disease CLINVAR Secondary genetic lesions in acute myeloid leukemia with inv(16) or t(16;16): a study of the German-Austrian AML Study Group (AMLSG). 23115274 2013
Entrez Id: 3717
Gene Symbol: JAK2
JAK2 		0.800 GeneticVariation disease CLINVAR Long term follow up of 93 families with myeloproliferative neoplasms: life expectancy and implications of JAK2V617F in the occurrence of complications. 22818858 2013
Entrez Id: 3717
Gene Symbol: JAK2
JAK2 		0.800 GeneticVariation disease CLINVAR De novo childhood myelodysplastic/myeloproliferative disease with unique molecular characteristics. 22571758 2012
Entrez Id: 3717
Gene Symbol: JAK2
JAK2 		0.800 GeneticVariation disease CLINVAR The oral HDAC inhibitor pracinostat (SB939) is efficacious and synergistic with the JAK2 inhibitor pacritinib (SB1518) in preclinical models of AML. 22829971 2012
Entrez Id: 3717
Gene Symbol: JAK2
JAK2 		0.800 GeneticVariation disease CLINVAR Phase 2 study of the JAK kinase inhibitor ruxolitinib in patients with refractory leukemias, including postmyeloproliferative neoplasm acute myeloid leukemia. 22422826 2012
Entrez Id: 3717
Gene Symbol: JAK2
JAK2 		0.800 GeneticVariation disease CLINVAR A patient with a 20-year lag phase between JAK2-V617F+ myeloproliferation and NPM1-mutated AML arguing against a common origin of disease. 21689158 2011
Entrez Id: 3717
Gene Symbol: JAK2
JAK2 		0.800 GeneticVariation disease CLINVAR A case of myeloid sarcoma with correlation to JAK2V617F mutation, complicated by myelofibrosis and secondary acute myeloid leukemia. 22041374 2011
Entrez Id: 3717
Gene Symbol: JAK2
JAK2 		0.800 GeneticVariation disease CLINVAR A prospective study of 338 patients with polycythemia vera: the impact of JAK2 (V617F) allele burden and leukocytosis on fibrotic or leukemic disease transformation and vascular complications. 20631743 2010
Entrez Id: 3717
Gene Symbol: JAK2
JAK2 		0.800 GeneticVariation disease CLINVAR JAK2 V617F mutation in myelodysplastic syndrome, myelodysplastic syndrome/myeloproliferative neoplasm, unclassifiable, refractory anemia with ring sideroblasts with thrombocytosis, and acute myeloid leukemia. 21120162 2010
Entrez Id: 3717
Gene Symbol: JAK2
JAK2 		0.800 GeneticVariation disease CLINVAR AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617F-independent overexpression of NF-E2. 20339092 2010
Entrez Id: 3717
Gene Symbol: JAK2
JAK2 		0.800 CausalMutation disease CLINVAR