Gene: GNAQ ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2776
Gene Symbol: GNAQ
GNAQ 		0.700 CausalMutation disease CGI
Entrez Id: 2776
Gene Symbol: GNAQ
GNAQ 		0.700 CausalMutation disease CLINVAR Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi. 19078957 2009
Entrez Id: 2776
Gene Symbol: GNAQ
GNAQ 		0.700 CausalMutation disease CLINVAR Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. 22733540 2012
Entrez Id: 2776
Gene Symbol: GNAQ
GNAQ 		0.700 CausalMutation disease CLINVAR Oncogenic mutations in GNAQ occur early in uveal melanoma. 18719078 2008
Entrez Id: 2776
Gene Symbol: GNAQ
GNAQ 		0.700 CausalMutation disease CLINVAR Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells. 1328859 1992
Entrez Id: 2776
Gene Symbol: GNAQ
GNAQ 		0.700 CausalMutation disease CLINVAR Protein kinase C inhibitor AEB071 targets ocular melanoma harboring GNAQ mutations via effects on the PKC/Erk1/2 and PKC/NF-κB pathways. 22653968 2012
Entrez Id: 2776
Gene Symbol: GNAQ
GNAQ 		0.700 CausalMutation disease CLINVAR The protein kinase C inhibitor enzastaurin exhibits antitumor activity against uveal melanoma. 22253748 2012
Entrez Id: 2776
Gene Symbol: GNAQ
GNAQ 		0.700 CausalMutation disease CLINVAR Impact of combined mTOR and MEK inhibition in uveal melanoma is driven by tumor genotype. 22808163 2012
Entrez Id: 2776
Gene Symbol: GNAQ
GNAQ 		0.700 CausalMutation disease CLINVAR GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. 2549426 1989
Entrez Id: 2776
Gene Symbol: GNAQ
GNAQ 		0.700 CausalMutation disease CLINVAR Mutations in GNA11 in uveal melanoma. 21083380 2010