Gene: GNAQ ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2776
Gene Symbol: GNAQ
GNAQ 		0.700 CausalMutation disease CLINVAR Oncogenic mutations in GNAQ occur early in uveal melanoma. 18719078 2008
Entrez Id: 2776
Gene Symbol: GNAQ
GNAQ 		0.700 CausalMutation disease CLINVAR Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells. 1328859 1992
Entrez Id: 2776
Gene Symbol: GNAQ
GNAQ 		0.700 CausalMutation disease CLINVAR Protein kinase C inhibitor AEB071 targets ocular melanoma harboring GNAQ mutations via effects on the PKC/Erk1/2 and PKC/NF-κB pathways. 22653968 2012
Entrez Id: 2776
Gene Symbol: GNAQ
GNAQ 		0.700 CausalMutation disease CLINVAR The protein kinase C inhibitor enzastaurin exhibits antitumor activity against uveal melanoma. 22253748 2012
Entrez Id: 2776
Gene Symbol: GNAQ
GNAQ 		0.700 CausalMutation disease CLINVAR Impact of combined mTOR and MEK inhibition in uveal melanoma is driven by tumor genotype. 22808163 2012
Entrez Id: 2776
Gene Symbol: GNAQ
GNAQ 		0.700 CausalMutation disease CLINVAR GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. 2549426 1989
Entrez Id: 2776
Gene Symbol: GNAQ
GNAQ 		0.700 CausalMutation disease CLINVAR Mutations in GNA11 in uveal melanoma. 21083380 2010
Entrez Id: 2776
Gene Symbol: GNAQ
GNAQ 		0.700 Biomarker disease CTD_human The mutations, such as those in NRAS, BRAF, GNAQ and GNA11, promote the growth of melanoma cells in most part through the mitogen-activated protein kinase (MAPK) pathway. 23432625 2013
Entrez Id: 2776
Gene Symbol: GNAQ
GNAQ 		0.700 CausalMutation disease CGI
Entrez Id: 2776
Gene Symbol: GNAQ
GNAQ 		0.700 GeneticVariation disease LHGDN Oncogenic mutations in GNAQ occur early in uveal melanoma. 18719078 2008