|
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study provided experimental evidence suggesting a limited heterogeneity in TCR Valpha gene rearrangements of MBP-reactive T cells in DR2 patients with MS.
|
9701037 |
1998 |
|
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Particular HLA genotypes may be associated with MS and recently also polymorphisms in the T-cell receptor (TCR) genes have been reported to correlate with the disease; however, these data have been difficult to confirm.
|
7911477 |
1994 |
|
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Analysis of TCR gene rearrangements has established some of the target antigens of the immune response in MS. Environmental influences on MS are described with particular attention given to how microbes might trigger demyelinating disease.
|
10735270 |
1997 |
|
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TCR beta polymorphisms and multiple sclerosis.
|
15175643 |
2004 |
|
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results demonstrate that a gene within the TCR beta complex or a closely linked locus influences susceptibility to MS.
|
2567636 |
1989 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunity to TCR peptides in multiple sclerosis. I. Successful immunization of patients with synthetic V beta 5.2 and V beta 6.1 CDR2 peptides.
|
7510746 |
1994 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
To gain insights into the interplay between MS and T cell repertoire, peripheral blood CD4+ and CD8+ T lymphocytes and their CCR7+/CCR7- subsets from five pairs of identical twins (four discordant and one concordant for MS; none of which had taken disease-modifying therapy) were compared by TCR beta-chain (TCRB) complementary-determining region 3 (CDR3) spectratyping.
|
17110420 |
2007 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest that Vbeta5.2 spectratype expansion is associated with the development of MS and that TCR-based immunotherapy can be applicable to MS patients if the TCR activation pattern of each patient is determined at different stages of the disease.
|
12707368 |
2003 |
|
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although SNPs implicating each of these regions of interest will require genotyping in independent replication cohorts, these findings suggest a role for TCR gene polymorphisms in MS susceptibility.
|
21270827 |
2011 |
|
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In order to establish whether such T cell responses are likely to be antigen-specific particularly with regard to myelin basic protein (MBP), we analysed T-cell receptor (TCR) gene rearrangements directly from MS brain plaques, using the polymerase chain reaction on reverse transcribed messenger RNA, and compared these with TCR of previously described MBP-specific T cell clones from MS and the rat model experimental allergic encephalomyelitis.
|
7680433 |
1993 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
The accumulation of activated T-cells in demyelinating MS lesions, the possible auto-immune mechanism of this disease and the functional relationship between MHC and T cell receptor (TCR) molecules support the hypothesis that TCR genes are good candidates to influence MS development.
|
8105988 |
1993 |