|
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The same TCR (N)Dbeta(N)Jbeta junctional region is associated with several different vbeta13 subtypes in a multiple sclerosis patient at the onset of the disease.
|
14678763 |
2003 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ex vivo detection of myelin basic protein-reactive T cells in multiple sclerosis and controls using specific TCR oligonucleotide probes.
|
14991617 |
2004 |
|
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TCR beta polymorphisms and multiple sclerosis.
|
15175643 |
2004 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
We suggest that the accumulation of highly antigen-sensitive EBNA1-specific Th1 cells in multiple sclerosis is capable of sustaining autoimmunity by cross-recognition of autoantigens or by TCR-independent bystander mechanisms.
|
16569670 |
2006 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly, some sequences resembled published oligoclonal CD8+ TCR sequences from MS lesions.
|
16935352 |
2006 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
To gain insights into the interplay between MS and T cell repertoire, peripheral blood CD4+ and CD8+ T lymphocytes and their CCR7+/CCR7- subsets from five pairs of identical twins (four discordant and one concordant for MS; none of which had taken disease-modifying therapy) were compared by TCR beta-chain (TCRB) complementary-determining region 3 (CDR3) spectratyping.
|
17110420 |
2007 |
|
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although SNPs implicating each of these regions of interest will require genotyping in independent replication cohorts, these findings suggest a role for TCR gene polymorphisms in MS susceptibility.
|
21270827 |
2011 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD8+ clones showed homology to published TCR from CNS-infiltrating T-cells in MS lesions.
|
21397340 |
2011 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
The role of CD28 in multiple sclerosis (MS) has been evaluated as the source of costimulatory signals integrating those delivered by TCR.
|
24412596 |
2014 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the effects of age and gut dysbiosis on the development of CNS autoimmunity in humanized transgenic mice expressing the MS-associated MHC class II (MHC-II) gene, HLA-DR2a, and T-cell receptor (TCR) genes specific for MBP87-99/DR2a that were derived from an MS patient.
|
29078267 |
2017 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pharmacological blockade of α<sub>1</sub>-adrenoceptor is shown to influence development of experimental autoimmune encephalomyelitis (EAE), an IL-17-producing CD4+TCR+ (Th17) cell-mediated disease mimicking multiple sclerosis.
|
31396845 |
2019 |