|
SERPINE1
|
0.300 |
Biomarker
|
disease |
BEFREE |
Independent predictors of death were PAI-1 rise and final Thrombolysis in Myocardial Infarction flow.
|
29972733 |
2018 |
|
SERPINE1
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The present study demonstrates that patients with AMI exhibit decreased miR-30b expression and elevated PAI-1 expression in the peripheral blood. miR-30b may therefore inhibit the damage to myocardial cells that occurs following AMI and protect myocardial cell function by targeting PAI-1 expression.
|
29805539 |
2018 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Our results showed that carriers of PAI-1 4G/5G genotype with myocardial infarction have increased odds of coronary artery occlusion more than 1.6 times in comparison to the carriers of homozygous genotypes.
|
26273123 |
2015 |
|
SERPINE1
|
0.300 |
Biomarker
|
disease |
BEFREE |
We aimed to investigate the association of plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (TPA) genes polymorphisms with myocardial infarction and its outcomes in Egyptian patients.
|
25113642 |
2015 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The Mendelian randomization meta-analysis confirmed previous knowledge that the PAI-1 4G allele slightly increases the risk for MI.
|
24695040 |
2014 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in plasminogen activator inhibitor-1 (PAI-1, SERPINE1) and tissue plasminogen activator (tPA, PLAT), such as PAI-1 (-675 4G/5G deletion/insertion) and tPA (Alu insertion/deletion [I/D]), are associated with strokes, myocardial infarctions, bacterial infections and septic shock severity, and trauma.
|
23570848 |
2013 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
MTHFRA1298C and PAI-1 deletions were most frequent genetic variants in risk groups for MI in patients with diabetes mellitus (value of odds ratio sequentially [OR] = 3.79, p = 0.06 and [OR] = 5 × 10(8), p = 0.000).
|
22752805 |
2012 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Two are associated with thrombophilia (765 4G/5G and -844 A>G, in the promoter), risk of myocardial infarction and postoperative deep venous thrombosis related to higher than normal levels of PAI-1.
|
21663586 |
2011 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In conclusion the PAI-1 gene polymorphism was found to have a gender specific role in the female MI patients.
|
21082259 |
2011 |
|
SERPINE1
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to investigate the association between PAI-1-844G/A and 4G/5G polymorphisms and changes in PAI-1 and tissue plasminogen activator (tPA) levels in MI in a Tunisian population.
|
19929406 |
2010 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Plasminogen activator inhibitor type-1 (PAI-1) has already been associated with atherosclerosis; myocardial infarction; and cardiovascular disease risk factors such as obesity, insulin resistance, and dyslipidemia.
|
20127289 |
2010 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The 4G allele of the PAI-1 -675(4G/5G) insertion/deletion promoter polymorphism has been associated with elevated plasma levels of PAI-1 and an increased risk of myocardial infarction.
|
20806116 |
2010 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We explored whether 4G/5G polymorphism of the PAI-1 gene is associated with the development of MI <or= 35 years of age.
|
19844663 |
2010 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In essence, tagging polymorphisms, including the 4G/5G polymorphism, and common haplotypes of the SERPINE1 gene region were not associated with MI in a German sample, and no compelling evidence was obtained for a relationship of the 4G/5G polymorphism to MI and coronary atherosclerosis in a meta-analysis.
|
20352162 |
2010 |
|
SERPINE1
|
0.300 |
Biomarker
|
disease |
BEFREE |
Myocardial infarction occurs with a similar 24 h pattern in the 4G/5G versions of plasminogen activator inhibitor-1.
|
19444746 |
2009 |
|
SERPINE1
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The PAI-1 HindIII polymorphism has been associated with high PAI-1 plasma levels in myocardial infarction patients and control populations.
|
19238514 |
2009 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
PAI-1 4G/4G genotype was the only independent variable (OR 2.67, 95%CI 1.43-4.96, P = 0.002) associated with MI in this regression model.
|
17721742 |
2008 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
PAI-1 4G/4G genotype was the only independent variable (OR 2.67, 95%CI 1.43-4.96, P = 0.002) associated with MI in this regression model.
|
17721742 |
2008 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
AMI is associated with polymorphisms in the NOS3 and FGB but not in PAI-1 genes in young adults.
|
17126309 |
2007 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Multivariable logistic regression analyses and stepwise forward selection procedures revealed that seven different polymorphisms were significantly (P<0.005) associated with MI in individuals with low or high serum concentrations of HDL- or LDL-cholesterol or of TG: the 190T --> C (Trp64Arg) polymorphism of ADRB3 in individuals with low HDL-cholesterol; the 1018C --> T (Thr145Met) polymorphism of GP1BA, the A --> G (Ile646Val) polymorphism of AKAP10, and the -55C --> T polymorphism of UCP3 in individuals with high HDL-cholesterol; the -603A --> G polymorphism of F3 and the -11377C --> G polymorphism of ADIPOQ in individuals with low LDL-cholesterol; the 1018C --> T polymorphism of GP1BA in individuals with low TG; and the 4G --> 5G polymorphism of PAI1 in individuals with high TG.
|
17786291 |
2007 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
SERPINE1 haplotypes are mildly associated with plasma levels of PAI-1 and with the risk of MI in nonsmokers.
|
17656673 |
2007 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
SERPINE1 haplotypes are mildly associated with plasma levels of PAI-1 and with the risk of MI in nonsmokers.
|
17656673 |
2007 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
GJA4 1019 C > T, MMP3 -1171delA, and SERPINE1 -668delG genotypes have been associated with the risk of incident myocardial infarction.
|
17719307 |
2007 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The 4G allele is associated with higher PAI-1 levels, but this study does not support an association of the PAI gene polymorphisms with the risk of either myocardial infarction or stroke.
|
17161063 |
2006 |
|
SERPINE1
|
0.300 |
Biomarker
|
disease |
BEFREE |
Polymorphisms of GJA4 and CYBA and of PAI1 and MMP3 are associated with myocardial infarction (MI) in men and women, respectively.
|
16998253 |
2006 |