×
Entrez Id:
646960
Gene Symbol:
PRSS56
PRSS56
0.440
PosttranslationalModification
disease
BEFREE
Finally, we demonstrate that genetic inactivation of Prss56 rescues axial elongation in a mouse model of myopia caused by a null mutation in Egr1.
29529029
2018
×
Entrez Id:
646960
Gene Symbol:
PRSS56
PRSS56
0.440
GeneticVariation
disease
GWASCAT
Detection and interpretation of shared genetic influences on 42 human traits.
27182965
2016
×
Entrez Id:
646960
Gene Symbol:
PRSS56
PRSS56
0.440
GeneticVariation
disease
BEFREE
We also found evidence of association with spherical equivalent on 2q37.1 in PRSS56 at rs1550094 (MAF = 31%, β = -0.33, p = 1.7 × 10(-3)), a region previously associated with myopia .
27440996
2016
×
Entrez Id:
646960
Gene Symbol:
PRSS56
PRSS56
0.440
GeneticVariation
disease
BEFREE
Two recent large-scale genome-wide association studies identified significant associations between myopia and single nucleotide polymorphisms (SNPs) near the PRSS56 , BMP3, KCNQ5, LAMA2, TOX, TJP2, RDH5, ZIC2, RASGRF1, GJD2, RBFOX1, and SHISA6 genes.
25587058
2015
×
Entrez Id:
646960
Gene Symbol:
PRSS56
PRSS56
0.440
GeneticVariation
disease
BEFREE
Transcripts of Prss56 , a gene associated with angle-closure glaucoma, posterior microphthalmia and myopia , were increased in Mfrprd6 eyes by 17-fold.
25357075
2014
×
Entrez Id:
646960
Gene Symbol:
PRSS56
PRSS56
0.440
Biomarker
disease
CTD_human
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.
23396134
2013
×
Entrez Id:
5923
Gene Symbol:
RASGRF1
RASGRF1
0.430
Biomarker
disease
BEFREE
Heritability of myopia and its relation with GDJ2 and RASGRF1 genes in Lithuania.
29793445
2018
×
Entrez Id:
5923
Gene Symbol:
RASGRF1
RASGRF1
0.430
AlteredExpression
disease
BEFREE
The aim of this study was to investigate the messenger RNA (mRNA) expression of Rasgrf1 in the eyes of guinea pigs with induced myopia .
27723119
2017
×
Entrez Id:
5923
Gene Symbol:
RASGRF1
RASGRF1
0.430
GeneticVariation
disease
GWASCAT
Detection and interpretation of shared genetic influences on 42 human traits.
27182965
2016
×
Entrez Id:
5923
Gene Symbol:
RASGRF1
RASGRF1
0.430
Biomarker
disease
CTD_human
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.
23396134
2013
×
Entrez Id:
5923
Gene Symbol:
RASGRF1
RASGRF1
0.430
Biomarker
disease
BEFREE
ZIC2 and RASGRF1 are susceptibility genes, not only for common myopia , but also for high myopia.
24150758
2013
×
Entrez Id:
9997
Gene Symbol:
SCO2
SCO2
0.420
Biomarker
disease
BEFREE
No other disease-causing mutation was found in 101 extremely myopic Japanese patients, suggesting that SCO2 plays a limited role in Japanese extreme myopia .
27052445
2016
×
Entrez Id:
9997
Gene Symbol:
SCO2
SCO2
0.420
GermlineCausalMutation
disease
ORPHANET
Messenger RNA levels of SCO2 were significantly downregulated in myopic mouse retinae.
23643385
2013
×
Entrez Id:
9997
Gene Symbol:
SCO2
SCO2
0.420
GeneticVariation
disease
BEFREE
The MYP6 locus is likely to contain susceptibility gene(s) for myopia , but none has yet been identified.
22792142
2012
×
Entrez Id:
1280
Gene Symbol:
COL2A1
COL2A1
0.420
GeneticVariation
disease
BEFREE
Association studies have revealed that the rs1635529 polymorphism in the COL2A1 (collagen, type Ⅱ, α 1) gene may be a potential candidate for myopia development and may be associated with myopia in Caucasians.
21993774
2012
×
Entrez Id:
1280
Gene Symbol:
COL2A1
COL2A1
0.420
GeneticVariation
disease
BEFREE
Significant association was identified between five SNPs (rs1034762 , rs1635529 , rs1793933 , rs3803183 , and rs17122571 ) of the COL2A1 locus and high-grade myopia (P < 0.045, minimum (min) P = 0.008) and with myopia status set at <or=-0.50 or -0.75 D (min P = 0.004) in the Duke dataset.
19387081
2009
×
Entrez Id:
1280
Gene Symbol:
COL2A1
COL2A1
0.420
Biomarker
disease
CTD_human
Candidate gene and locus analysis of myopia.
17653045
2007
×
Entrez Id:
1280
Gene Symbol:
COL2A1
COL2A1
0.420
Biomarker
disease
HPO
×
Entrez Id:
1280
Gene Symbol:
COL2A1
COL2A1
0.420
CausalMutation
disease
CLINVAR
×
Entrez Id:
9997
Gene Symbol:
SCO2
SCO2
0.420
Biomarker
disease
HPO
×
Entrez Id:
3908
Gene Symbol:
LAMA2
LAMA2
0.410
GeneticVariation
disease
BEFREE
Genetic studies have reported a significant association of the single nucleotide polymorphism (SNP) in the LAMA2 gene with myopia .
26984843
2016
×
Entrez Id:
5959
Gene Symbol:
RDH5
RDH5
0.410
GeneticVariation
disease
GWASCAT
Detection and interpretation of shared genetic influences on 42 human traits.
27182965
2016
×
Entrez Id:
3908
Gene Symbol:
LAMA2
LAMA2
0.410
GeneticVariation
disease
GWASCAT
Detection and interpretation of shared genetic influences on 42 human traits.
27182965
2016
×
Entrez Id:
5959
Gene Symbol:
RDH5
RDH5
0.410
Biomarker
disease
BEFREE
Although two previous studies suggested strong associations between PRSS56, LAMA2, TOX, and RDH5 and myopia , we could not replicate these results.
25335978
2014
×
Entrez Id:
3908
Gene Symbol:
LAMA2
LAMA2
0.410
Biomarker
disease
CTD_human
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.
23396134
2013