The frequencies of MDR1G2677T/A GT, GA, TT+AA genotypes or T allele, MDR1C3435T TT genotype, and T allele genotype frequencies were significantly increased in NS group.
We undertook this study to examine the distribution of three most frequent MDR-1 exonic polymorphisms G3435C, G2677T/A and C1236T in patients with NS and control children to investigate their usefulness as markers of responsiveness of the disease to steroids.
Our aim was to assess the relation of serum soluble interleukin-2 receptor (sIL2R) levels and MDR1 gene expression on lymphocytes with nephrotic syndrome and its corticosteroids therapy.