Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.010 AlteredExpression group BEFREE IL-13 is an important mediator of antiinflammatory immune responses and is expressed in the thyroid and orbit. 15483090 2005
Entrez Id: 5604
Gene Symbol: MAP2K1
MAP2K1
0.010 GeneticVariation group BEFREE MAP2K1 mutations were detected in 6 of 13 (46%) BRAF-negative cases including 2 (100%) lymph node, 2 (50%) bone, 1 (25%) skin, and 1 (100%) orbit. 26980021 2016
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.040 Biomarker group BEFREE IL-6 plays an important role in ocular inflammation and angiogenesis in conjunctiva, cornea, iris, retina, and orbit. 28146368 2018
Entrez Id: 947
Gene Symbol: CD34
CD34
0.070 Biomarker group BEFREE CD34 + tumours of the orbit including solitary fibrous tumours: a six-case series. 28449640 2017
Entrez Id: 9518
Gene Symbol: GDF15
GDF15
0.010 Biomarker group BEFREE GDF-15 improved the c index of both the HAS-BLED (0.62-0.69) and ORBIT (0.68-0.71) bleeding risk scores. 28760218 2017
Entrez Id: 23218
Gene Symbol: NBEAL2
NBEAL2
0.070 Biomarker group BEFREE GPS Satellite Orbit Prediction at User End for Real-Time PPP System. 28867771 2017
Entrez Id: 4306
Gene Symbol: NR3C2
NR3C2
0.010 Biomarker group BEFREE Mineralocorticoid Receptor Antagonism in Patients With Atrial Fibrillation: Findings From the ORBIT-AF (Outcomes Registry for Better Informed Treatment of Atrial Fibrillation) Registry. 29654203 2018
Entrez Id: 9353
Gene Symbol: SLIT2
SLIT2
0.010 Biomarker group BEFREE Slit2 Modulates the Inflammatory Phenotype of Orbit-Infiltrating Fibrocytes in Graves' Disease. 29752312 2018
Entrez Id: 4907
Gene Symbol: NT5E
NT5E
0.010 Biomarker group BEFREE CD73 Is Enriched in Cutaneous Carcinomas That Invade the Orbit. 31743281 2019
Entrez Id: 23218
Gene Symbol: NBEAL2
NBEAL2
0.070 Biomarker group BEFREE Although increased C/N0 thresholds can improve the overall data quality, the available number of GPS observations is greatly reduced and the resulting orbit solution is poor. 28587174 2017
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 GeneticVariation group BEFREE Although the presence of this TSH-R variant could provide the antigenic link between the thyroid and the orbit in Graves' disease and thyroid-associated ophthalmopathy (TAO), the etiopathophysiological significance of this finding remains to be elucidated. 8751142 1995
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 Biomarker group BEFREE As the TSH receptor (TSHR) is the primary target for autoimmunity against the thyroid in Graves' disease, much effort has gone into investigating the role of TSHR messenger ribonucleic acid (mRNA) transcripts in extrathyroidal tissue, particularly in the orbit. 11344244 2001
Entrez Id: 8878
Gene Symbol: SQSTM1
SQSTM1
0.010 Biomarker group BEFREE BLANT offers sampled graphlets in various forms: distributions of graphlets or their orbits; graphlet degree or graphlet orbit degree vectors, the latter being compatible with ORCA; or an index to be used as the basis for seed-and-extend local alignments. 31373347 2019
Entrez Id: 222229
Gene Symbol: LRWD1
LRWD1
0.010 Biomarker group BEFREE BLANT offers sampled graphlets in various forms: distributions of graphlets or their orbits; graphlet degree or graphlet orbit degree vectors, the latter being compatible with ORCA; or an index to be used as the basis for seed-and-extend local alignments. 31373347 2019
Entrez Id: 947
Gene Symbol: CD34
CD34
0.070 Biomarker group BEFREE Bone marrow-derived CD34⁺ fibrocytes infiltrate the orbit in TAO where they become CD34⁺ orbital fibroblasts. 23633206 2013
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.010 AlteredExpression group BEFREE Cell density-dependent regulation of PAI-1 expression in the orbit, together with the local cytokine environment, may have a regulatory role in the turnover of the orbital ECM and may contribute to the expansion of orbital soft tissue in GO. 26979769 2016
Entrez Id: 102723407
Gene Symbol: LOC102723407
LOC102723407
0.010 GeneticVariation group BEFREE Clonal IGHV gene sequences were identified in 43 tumors originating from the orbit (19), conjunctivae (18) and lacrimal gland (6). 22216179 2011
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.010 GeneticVariation group BEFREE Clonal IGHV gene sequences were identified in 43 tumors originating from the orbit (19), conjunctivae (18) and lacrimal gland (6). 22216179 2011
Entrez Id: 102724971
Gene Symbol: LOC102724971
LOC102724971
0.010 GeneticVariation group BEFREE Clonal IGHV gene sequences were identified in 43 tumors originating from the orbit (19), conjunctivae (18) and lacrimal gland (6). 22216179 2011
Entrez Id: 28402
Gene Symbol: IGHV3-69-1
IGHV3-69-1
0.010 GeneticVariation group BEFREE Clonal IGHV gene sequences were identified in 43 tumors originating from the orbit (19), conjunctivae (18) and lacrimal gland (6). 22216179 2011
Entrez Id: 28309
Gene Symbol: IGHV3OR16-7
IGHV3OR16-7
0.010 GeneticVariation group BEFREE Clonal IGHV gene sequences were identified in 43 tumors originating from the orbit (19), conjunctivae (18) and lacrimal gland (6). 22216179 2011
Entrez Id: 8856
Gene Symbol: NR1I2
NR1I2
0.010 Biomarker group BEFREE Comparison of Orbit-Based and Time-Offset-Based Geometric Correction Models for SAR Satellite Imagery Based on Error Simulation. 28106729 2017
Entrez Id: 6345
Gene Symbol: SRL
SRL
0.010 Biomarker group BEFREE Comparison of Orbit-Based and Time-Offset-Based Geometric Correction Models for SAR Satellite Imagery Based on Error Simulation. 28106729 2017
Entrez Id: 1757
Gene Symbol: SARDH
SARDH
0.010 Biomarker group BEFREE Comparison of Orbit-Based and Time-Offset-Based Geometric Correction Models for SAR Satellite Imagery Based on Error Simulation. 28106729 2017
Entrez Id: 23218
Gene Symbol: NBEAL2
NBEAL2
0.070 Biomarker group BEFREE During high ionospheric activity, the mean Root Mean Square (RMS) of Swarm GPS phase residuals is at 9-11 mm, Swarm orbit solutions are also compared with Swarm PSOs released by ESA and the accuracy of Swarm orbits can reach 2-4 cm in R, T and N directions. 28335538 2017