| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.300 | Biomarker | disease | CTD_human | Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits. | 28604731 | 2017 | ||||
|
0.300 | Biomarker | disease | CTD_human | Genetics of caffeine consumption and responses to caffeine. | 20532872 | 2010 | ||||
|
0.300 | Biomarker | disease | CTD_human | Nail-patella syndrome with an emphasis on the risk of renal and ocular findings. | 20199424 | 2010 | ||||
|
0.300 | Biomarker | disease | CTD_human | Functional characterization of the new human GABA(A) receptor mutation beta3(R192H). | 12189488 | 2002 | ||||
|
0.030 | Biomarker | disease | BEFREE | Research on the development of orexin receptor antagonists has dramatically increased with the approval of suvorexant for the treatment of primary insomnia. | 31782044 | 2019 | ||||
|
0.030 | Biomarker | disease | BEFREE | The orally active dual OX<sub>1</sub>R and OX<sub>2</sub>R antagonist, almorexant, targets the orexin system for the treatment of primary insomnia. | 28735928 | 2017 | ||||
|
0.030 | Biomarker | disease | BEFREE | A mechanistic hypothesis coupled with an in vitro assay to assess bioactivation led to replacement of the fluoroquinazoline ring of 10 with a chlorobenzoxazole to provide 3 (MK-4305), a potent dual orexin receptor antagonist that is currently being tested in phase III clinical trials for the treatment of primary insomnia. | 20565075 | 2010 | ||||
|
0.010 | GeneticVariation | disease | BEFREE | To investigate the relationship between exonic variant (rs4290270) in the tryptophan hydroxylase-2 gene and primary insomnia and symptoms of depression in Han Chinese. | 29952309 | 2018 | ||||
|
0.010 | GeneticVariation | disease | BEFREE | We aimed at determining PSMD9 rs74421874/rs3825172/rs14259 SNPs potential linkage to primary insomnia and sleep hours in T2D families. | 26166263 | 2015 |