Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.100 Biomarker phenotype HPO
Entrez Id: 4179
Gene Symbol: CD46
CD46
0.100 Biomarker phenotype HPO
Entrez Id: 3426
Gene Symbol: CFI
CFI
0.100 Biomarker phenotype HPO
Entrez Id: 5376
Gene Symbol: PMP22
PMP22
0.100 Biomarker phenotype HPO
Entrez Id: 101101692
Gene Symbol: HELLPAR
HELLPAR
0.100 Biomarker phenotype HPO
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.040 AlteredExpression phenotype BEFREE IL-1β levels in shoulder synovial fluid correlated positively with shoulder pain and functional scores in patients with chronic RCTs. 29169956 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.040 GeneticVariation phenotype BEFREE Results from the recruited cohort (n = 190) indicated strong statistical evidence for the interactions between 1) TNF/LTA SNP rs2229094 and depression symptoms for average pain intensity and duration and 2) IL1B two SNP diplotype and kinesiophobia for average shoulder pain intensity. 24598699 2014
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.040 AlteredExpression phenotype BEFREE The present study was undertaken to determine the relationship between mRNA expression levels of IL-1beta and its receptor antagonists (secreted interleukin-1 receptor antagonist (IL-1ra) and intracellular IL-1ra) in the synovium of the glenohumeral joint and shoulder pain in rotator cuff diseases, analyzing the synovial specimens by reverse transcriptase polymerase chain reaction. 12472254 2002
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.040 Biomarker phenotype BEFREE The differential regulation of the two forms of IL-1ra mRNAs may play an important role in shoulder pain in rotator cuff diseases, regulating IL-1-induced subacromial synovitis. 11561109 2001
Entrez Id: 6094
Gene Symbol: ROM1
ROM1
0.020 Biomarker phenotype BEFREE (1) Is gender associated with differences in rTSA outcome scores like the Simple Shoulder Test (SST), the UCLA Shoulder score, the American Shoulder and Elbow Surgeons (ASES) Shoulder score, the Constant Shoulder score, and the Shoulder Pain and Disability Index (SPADI) and ROM? 29601384 2018
Entrez Id: 6094
Gene Symbol: ROM1
ROM1
0.020 Biomarker phenotype BEFREE After 4 weeks of physical therapy, the patient's shoulder pain had reduced and the passive ROM was nearly full. 29245218 2017
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.020 GeneticVariation phenotype BEFREE This study investigated whether psychological variables specific to fear-avoidance models and catechol-O-methyltransferase (COMT) genotype influenced pain ratings for a cohort of patients receiving operative treatment of shoulder pain. 17686583 2008
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.020 GeneticVariation phenotype BEFREE A previous study suggested pain catastrophizing and catechol-O-methyltransferase (COMT) genotype influenced clinical pain ratings for patients seeking operative treatment of shoulder pain. 18936597 2008
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
0.020 Biomarker phenotype BEFREE The present study was undertaken to determine the relationship between mRNA expression levels of IL-1beta and its receptor antagonists (secreted interleukin-1 receptor antagonist (IL-1ra) and intracellular IL-1ra) in the synovium of the glenohumeral joint and shoulder pain in rotator cuff diseases, analyzing the synovial specimens by reverse transcriptase polymerase chain reaction. 12472254 2002
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
0.020 AlteredExpression phenotype BEFREE The differential regulation of the two forms of IL-1ra mRNAs may play an important role in shoulder pain in rotator cuff diseases, regulating IL-1-induced subacromial synovitis. 11561109 2001
Entrez Id: 653509
Gene Symbol: SFTPA1
SFTPA1
0.010 Biomarker phenotype BEFREE The current study results demonstrate proof-of-concept regarding the 3D-SPA mobilization, and this approach should be considered as an alternative to the uni-dimensional mobilizations currently used in clinical treatment guidelines for post-stroke shoulder pain. 30907155 2019
Entrez Id: 6364
Gene Symbol: CCL20
CCL20
0.010 Biomarker phenotype BEFREE Therefore, in this study, we aimed to 1) compare the clinical effects between acupuncture at the contralateral and ipsilateral Tiaokou (ST 38) point in patients with unilateral shoulder pain and 2) explore how contralateral- and ipsilateral-acupuncture modulates the regional homogeneity (ReHo) of patients with CSP. 29563830 2018
Entrez Id: 49
Gene Symbol: ACR
ACR
0.010 Biomarker phenotype BEFREE ACR Appropriateness Criteria<sup>®</sup> Shoulder Pain-Atraumatic. 30392607 2018
Entrez Id: 5067
Gene Symbol: CNTN3
CNTN3
0.010 Biomarker phenotype BEFREE Secondary outcome measures were assessed, including physical and mental component scores (PCS and MCS) of health-related quality of life (HRQOL), fatigue, global fatigue (FSS), and shoulder pain index (WUSPI). 29902472 2018
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.010 AlteredExpression phenotype BEFREE Shoulder pain and intra-articular interleukin-8 levels in patients with rotator cuff tears. 25930944 2017
Entrez Id: 3787
Gene Symbol: KCNS1
KCNS1
0.010 Biomarker phenotype BEFREE There was moderate statistical evidence for interactions for other shoulder pain phenotypes between additional genes (ADRB2, AVPR1 A, and KCNS1) and depressive symptoms, pain catastrophizing, or kinesiophobia. 24373571 2014
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
0.010 Biomarker phenotype BEFREE There was moderate statistical evidence for interactions for other shoulder pain phenotypes between additional genes (ADRB2, AVPR1 A, and KCNS1) and depressive symptoms, pain catastrophizing, or kinesiophobia. 24373571 2014
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.010 GeneticVariation phenotype BEFREE Results from the recruited cohort (n = 190) indicated strong statistical evidence for the interactions between 1) TNF/LTA SNP rs2229094 and depression symptoms for average pain intensity and duration and 2) IL1B two SNP diplotype and kinesiophobia for average shoulder pain intensity. 24598699 2014
Entrez Id: 3552
Gene Symbol: IL1A
IL1A
0.010 Biomarker phenotype BEFREE The differential regulation of the two forms of IL-1ra mRNAs may play an important role in shoulder pain in rotator cuff diseases, regulating IL-1-induced subacromial synovitis. 11561109 2001