| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.100 | Biomarker | group | BEFREE | RIG-I Activation Protects and Rescues from Lethal Influenza Virus Infection and Bacterial Superinfection. | 28760668 | 2017 | ||||
|
0.100 | Biomarker | group | BEFREE | RIG-I-like receptors detect viral RNA in infected cells and promote oligomerization of the outer mitochondrial membrane protein MAVS to induce innate immunity to viral infection through type I interferon production. | 26317833 | 2015 | ||||
|
0.100 | Biomarker | group | BEFREE | RIG-I-like receptor regulation in virus infection and immunity. | 25644461 | 2015 | ||||
|
0.100 | Biomarker | group | BEFREE | RIG-I-like receptors (RLRs: RIG-I, MDA5 and LGP2) play a major role in the innate immune response against viral infections and detect patterns on viral RNA molecules that are typically absent from host RNA. | 24743923 | 2014 | ||||
|
0.100 | Biomarker | group | BEFREE | RIG-I is a cytoplasmic viral RNA sensor that triggers the signal to induce type I interferon production in response to viral infection. | 23950712 | 2013 | ||||
|
0.100 | Biomarker | group | BEFREE | RIG-I-like receptors and Toll-like receptors (TLRs) play important roles in the recognition of viral infections. | 22072781 | 2012 | ||||
|
0.100 | AlteredExpression | group | BEFREE | RIG-I-like receptors (RLRs) are expressed ubiquitously at low levels, and their expression is induced by treatment with type I interferon (IFN) or a viral infection. | 20950133 | 2011 | ||||
|
0.100 | Biomarker | group | BEFREE | RIG-I and MDA5 are cytoplasmic DEX(D/H) helicase proteins that can induce signaling in response to RNA ligands, including those from viral infections. | 18411269 | 2008 | ||||
|
0.100 | Biomarker | group | BEFREE | Virus infection is sensed in the cytoplasm by retinoic acid-inducible gene I (RIG-I, also known as DDX58), which requires RNA and polyubiquitin binding to induce type I interferon (IFN) and activate cellular innate immunity. | 24931123 | 2014 |