In this study, we therefore aimed to explore the risk factors associated with the incidence of problem drinking among evacuees after the Great East Japan Earthquake of March 11, 2011.
In current study, chronic-binge alcohol abuse model was employed to investigate the therapeutic effects of BMMSCs and BMMSCs pre-activated with TLR3 (P-BMMSCs) on alcohol-induced liver and intestine damage.
In alcoholics, compared to the controls, we found: a significant increase in serum: AST (p = 0.0014), ALT (p = 0.0071), AST/ALT ratio (p < 0.000); significantly lower plasma free carnitine (FC) (p = 0.0316) and total carnitine (TC) (p = 0.0349); and a significant negative correlation between FC (r = -0.6200; R<sup>2</sup> = 0.3844; p = 0.0007), TC (r = -0.4365; R<sup>2</sup> = 0.1905; p = 0.0258), and time of alcohol dependence, suggesting carnitine as an indirect marker of alcohol abuse.
The present findings suggest that hemopexin and properdin show potential as markers for physiological effects that may arise in HIV-infected individuals who abuse alcohol and tobacco.
High expression of TFR-1 in HCC was associated with the absence of alcohol abuse (P = 0.0467), liver cirrhosis (P < 0.0001), higher alpha-fetoprotein (AFP; P < 0.0001), smaller tumour size (P = 0.0022), poor histological differentiation (P < 0.0001) and morphological features (P < 0.0001).
Porphyria cutanea tarda (PCT) is the most common human porphyria, due to hepatic deficiency of uroporphyrinogen decarboxylase (UROD), which is acquired in the presence of iron overload and various susceptibility factors, such as alcohol abuse, smoking, hepatitis C virus (HCV) infection, HIV infection, iron overload with HFE gene mutations, use of estrogens, and UROD mutation.
This study evaluates whether a group intervention that included cognitive remediation improved ART adherence, service utilization, and viral load among HIV-positive adults with a history of alcohol abuse.
The primary outcomes were daily alcohol consumption, binge drinking, problem drinking (CAGE score 2+) and smoking status in relation to tagging variants within the FTO and ADH1B genes.
This study evaluates whether a group intervention that included cognitive remediation improved ART adherence, service utilization, and viral load among HIV-positive adults with a history of alcohol abuse.
Functional enrichment of the miR-183C and miR-200a/b family target genes, revealed neuroinflammatory pathways networks involved in TLR4 signaling and alcohol abuse.
The primary aim of this study was to estimate the relationship between CYP3A5 gene polymorphism, activity of the CYP3A isoenzyme, and the risk of development of adverse drug reactions by haloperidol in patients with alcohol abuse.
No correlation was found between gene expression and clinical parameters, except DAPK1, where low expression correlated with alcohol abuse (0.85 ±1.19 vs 1.97 ±3.22; p = 0.074).
Race moderated the association between alcohol abuse and CRP (b = 0.56, SE = 0.28, p = 0.048), IL-6 (b = 0.65, SE = 0.22, p = 0.004), and a composite inflammation score (b = 0.014, SE = 0.07, p = 0.041).
The analysis of the study material showed abdominal obesity in 63% of patients, more likely in women (p < 0.001); increased total cholesterol values in 30% of patients, more frequently in women (p = 0.025); blood pressure values ≥140/90 mm Hg in 28% of patients, more frequently in men (p < 0.001); alcohol abuse (≥5 points in the Michigan Alcoholism Screening Test, MAST) in 12.6% of patients, more frequently in men (p < 0.001).
Apremilast produced stable reductions in voluntary EtOH consumption and was rapidly distributed to plasma and tissues (including the brain), suggesting that it may be an improved PDE4 inhibitor for medication development and repurposing efforts to treat alcohol abuse.
This study may provide the scientific basis for further studies addressing whether the application of exogenous BMP-2 in patients with a history of alcohol abuse who sustain long bone fractures may or may not be of benefit.
The analysis of the study material showed abdominal obesity in 63% of patients, more likely in women (p < 0.001); increased total cholesterol values in 30% of patients, more frequently in women (p = 0.025); blood pressure values ≥140/90 mm Hg in 28% of patients, more frequently in men (p < 0.001); alcohol abuse (≥5 points in the Michigan Alcoholism Screening Test, MAST) in 12.6% of patients, more frequently in men (p < 0.001).