×
Entrez Id:
3159
Gene Symbol:
HMGA1
HMGA1
0.520
Biomarker
disease
BEFREE
Our work also suggests that targeting HMGA1 could be effective adjuvant therapy for more aggressive uterine cancers and provides compelling data for further preclinical studies.
27001612
2016
×
Entrez Id:
3159
Gene Symbol:
HMGA1
HMGA1
0.520
Biomarker
disease
CTD_human
Both drugs block anchorage-independent growth in high-grade human uterine cancer cells that overexpress HMGA1a (MES-SA cells).
18645019
2008
×
Entrez Id:
3159
Gene Symbol:
HMGA1
HMGA1
0.520
Biomarker
disease
BEFREE
Although a larger study is needed to confirm these results, HMGA1a may be a useful marker for aggressive human uterine cancers .
17483309
2007
×
Entrez Id:
3159
Gene Symbol:
HMGA1
HMGA1
0.520
Biomarker
disease
MGD
×
Entrez Id:
580
Gene Symbol:
BARD1
BARD1
0.320
GeneticVariation
disease
BEFREE
Mutations in tumor-suppressor gene BARD1 have been found in inherited and spontaneous breast, ovarian and uterine cancers .
16152612
2006
×
Entrez Id:
580
Gene Symbol:
BARD1
BARD1
0.320
GeneticVariation
disease
BEFREE
Mutations in the BRCA1-associated RING domain (BARD1 ) gene in primary breast, ovarian and uterine cancers .
9425226
1998
×
Entrez Id:
580
Gene Symbol:
BARD1
BARD1
0.320
GeneticVariation
disease
UNIPROT
×
Entrez Id:
3219
Gene Symbol:
HOXB9
HOXB9
0.300
Biomarker
disease
CTD_human
Endocrine disrupting chemical, bisphenol-A, induces breast cancer associated gene HOXB9 expression in vitro and in vivo.
27182052
2016
×
Entrez Id:
8314
Gene Symbol:
BAP1
BAP1
0.300
Biomarker
disease
CTD_human
Inference on germline BAP1 mutations and asbestos exposure from the analysis of familial and sporadic mesothelioma in a high-risk area.
25231345
2015
×
Entrez Id:
4088
Gene Symbol:
SMAD3
SMAD3
0.300
Biomarker
disease
CTD_human
A high concentration of genistein down-regulates activin A, Smad3 and other TGF-β pathway genes in human uterine leiomyoma cells.
22228119
2012
×
Entrez Id:
3624
Gene Symbol:
INHBA
INHBA
0.300
Biomarker
disease
CTD_human
A high concentration of genistein down-regulates activin A, Smad3 and other TGF-β pathway genes in human uterine leiomyoma cells.
22228119
2012
×
Entrez Id:
8842
Gene Symbol:
PROM1
PROM1
0.300
Biomarker
disease
CTD_human
CD133+ cancer stem cell-like cells derived from uterine carcinosarcoma (malignant mixed Müllerian tumor).
21919130
2011
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
0.300
Biomarker
disease
CTD_human
K-ras mutations in lung tumors and tumors from other organs are consistent with a common mechanism of ethylene oxide tumorigenesis in the B6C3F1 mouse.
17325976
2007
×
Entrez Id:
1027
Gene Symbol:
CDKN1B
CDKN1B
0.300
Biomarker
disease
CTD_human
A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression.
16391232
2006
×
Entrez Id:
1440
Gene Symbol:
CSF3
CSF3
0.300
Therapeutic
disease
CTD_human
Phase II trial of paclitaxel in patients with soft-tissue sarcoma.
9774950
1998
×
Entrez Id:
4436
Gene Symbol:
MSH2
MSH2
0.100
CausalMutation
disease
CLINVAR
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
0.040
GeneticVariation
disease
BEFREE
Israeli BRCA1 or BRCA2 mutation carriers are at an increased risk for developing uterine cancer , especially serous papillary and sarcoma.
30489631
2019
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
0.040
GeneticVariation
disease
BEFREE
Mortality reduction and cost-effectiveness of performing hysterectomy at the time of risk-reducing salpingo-oophorectomy for prophylaxis against serous/serous-like uterine cancers in BRCA1 mutation carriers.
28390820
2017
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
0.040
GeneticVariation
disease
BEFREE
Risk of uterine cancer for BRCA1 and BRCA2 mutation carriers.
28802188
2017
×
Entrez Id:
672
Gene Symbol:
BRCA1
BRCA1
0.040
GeneticVariation
disease
BEFREE
Mutations in the BRCA1 -associated RING domain (BARD1) gene in primary breast, ovarian and uterine cancers .
9425226
1998
×
Entrez Id:
5728
Gene Symbol:
PTEN
PTEN
0.030
Biomarker
disease
BEFREE
In humans, a PMN gene signature correlated with improved survival in several cancer subtypes, including PTEN -deficient uterine cancer .
26678340
2015
×
Entrez Id:
5728
Gene Symbol:
PTEN
PTEN
0.030
Biomarker
disease
BEFREE
In vitro and in vivo therapeutic experiments were carried out using PTEN-mutated and PTEN -wild-type models of uterine cancer alone and in combination with chemotherapy.
25833835
2015
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
0.030
AlteredExpression
disease
BEFREE
Thus, Pten and Pik3ca have distinct consequences on the activation of the phosphatidylinositol 3-kinase pathway in endometrial epithelium and are likely to affect other nonoverlapping cellular mechanisms involved in the development and progression of the most common type of uterine cancer .
25698082
2015
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
0.030
Biomarker
disease
BEFREE
Inhibitors of the PI3K pathway are in clinical testing in patients with solid tumors, including uterine cancer .
21903247
2011
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
0.030
GeneticVariation
disease
BEFREE
Mutations and amplifications of the PIK3CA gene are relatively infrequent in human cervical and endometrial cancers; however, PIK3CA gene alteration may still play a role in some subset of uterine cancers .
18180098
2008