| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.020 | AlteredExpression | disease | BEFREE | The shift from typical to atypical depression is due to an inhibitory effect of higher circulating leptin on HPA axis activity and subsequent decrease in the lipolytic effects of cortisol. | 31347937 | 2019 | ||||
|
0.020 | Biomarker | disease | BEFREE | Development of treatment effectively targeting leptin resistance may benefit patients with atypical depression characterized by obesity-related metabolic alterations. | 26742925 | 2017 | ||||
|
0.010 | Biomarker | disease | BEFREE | In this secondary analysis of a trial of PPD treatment, depressive symptoms (Structured Interview Guide for the Hamilton Depression Rating Scale-Atypical Depression Symptoms (SIGH-ADS<sub>29</sub>)) and serum CRP levels were assessed and associations between CRP and SIGH-ADS<sub>29</sub> scores evaluated. | 29654412 | 2019 | ||||
|
0.010 | Biomarker | disease | BEFREE | Atypical depression is associated with increased IL-6 trans-signaling and lipid peroxidation. | 28867391 | 2018 | ||||
|
0.010 | Biomarker | disease | BEFREE | This study provides new insights on the possible influence of MCHR2 and/or MCHR2-AS1 on obesity in psychiatric patients and on the pathophysiology of atypical depression. | 26461262 | 2015 | ||||
|
0.010 | Biomarker | disease | BEFREE | This study provides new insights on the possible influence of MCHR2 and/or MCHR2-AS1 on obesity in psychiatric patients and on the pathophysiology of atypical depression. | 26461262 | 2015 | ||||
|
0.010 | GeneticVariation | disease | BEFREE | The mediational statistical analyses showed the CSF-HVA concentration as a key driver of the relationship between MAOA-uVNTR genotype and AD. | 19214141 | 2009 | ||||
|
0.010 | GeneticVariation | disease | BEFREE | To further delineate the impact of 5-HTT gene variation on psychopathology in depression, in this analysis the influence of the 5-HTTLPR and the functionally closely related 5-HTT rs25531 was investigated in 340 Caucasian patients with a major depressive episode (DSM-IV) with particular attention to the subtype of depression (melancholic depression versus atypical depression) applying logistic regression models adjusted for age and gender. | 18050262 | 2008 |