Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 Biomarker phenotype BEFREE Interleukin-6 (IL-6) is known to be involved in the pathogenesis of cancer progression. 28548958 2018
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 Biomarker phenotype BEFREE Osteopontin at the Crossroads of Inflammation and Tumor Progression. 28769537 2018
Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
0.100 AlteredExpression phenotype BEFREE HOXB7 promotes tumor progression via bFGF-induced activation of MAPK/ERK pathway and indicated poor prognosis in hepatocellular carcinoma. 28454092 2018
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.100 GeneticVariation phenotype BEFREE The hypoxia inducible factor 1-alpha (HIF1A) gene has been suggested to play a critical role in cancer progression, and the relationship between HIF1A rs11549465 polymorphism and risk of prostate cancer has been investigated in previous studies. 28415653 2018
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.100 Biomarker phenotype BEFREE EZH2 interacts with both histone and non-histone proteins to modulate diverse physiological functions including cancer progression and malignancy. 28561778 2018
Entrez Id: 4316
Gene Symbol: MMP7
MMP7
0.100 Biomarker phenotype BEFREE Matrix metalloproteinase-7 (MMP-7) plays important roles in tumor progression and metastasis. 29046355 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker phenotype BEFREE WT p53 is critical for tumor suppression, whereas mutant p53 promotes tumor progression. 29073078 2018
Entrez Id: 4072
Gene Symbol: EPCAM
EPCAM
0.100 Biomarker phenotype BEFREE Upregulation of the epithelial cell adhesion molecule (EpCAM) is involved in tumor progression. 28393249 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 Biomarker phenotype BEFREE High-mobility group protein two (HMGA2), a nonhistone nuclear-binding protein and its downregulators; vimentin, matrix metallopeptidase-9 (MMP-9), and E-cadherin are shown to contribute to tumor progression and metastasis. 27188536 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker phenotype BEFREE Stress-induced EGF receptor signaling through STAT3 and tumor progression in triple-negative breast cancer. 28088463 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker phenotype BEFREE The epidermal growth factor receptor (EGFR) is a well-studied receptor-tyrosine kinase that serves vital roles in regulation of organ development and cancer progression. 28428083 2018
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.100 Biomarker phenotype BEFREE ABCG2, CD133 and CD117 are pivotal markers of cancer stem cell, which are involved in carcinogenesis and cancer progression. 26951883 2018
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.100 Biomarker phenotype BEFREE The hypoxia-induced Epithelial to Mesenchymal Transition (EMT), driven by HIF1α, is known to be involved in cancer progression and metastasis. 28061476 2018
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.100 Biomarker phenotype BEFREE Targeting miR-21 with Sophocarpine Inhibits Tumor Progression and Reverses Epithelial-Mesenchymal Transition in Head and Neck Cancer. 28571917 2018
Entrez Id: 2305
Gene Symbol: FOXM1
FOXM1
0.100 Biomarker phenotype BEFREE Forkhead box protein M1 (FoxM1) has been associated with cancer progression and metastasis. 29360662 2018
Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
0.100 Biomarker phenotype BEFREE Although aberrant expression of Runt-related transcription factor 3 (RUNX3) contributes to tumor progression and metastasis in a number of carcinomas, the status of RUNX3 and its correlation with prognosis in oral squamous cell carcinomas (OSCC) are still controversial. 28765934 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 Biomarker phenotype BEFREE Overexpression of the tumor necrosis factor receptor-associated factor 4 (TRAF4) has been detected in many cancer types and is considered to foster tumor progression. 28256185 2018
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.100 Biomarker phenotype BEFREE Stress-induced EGF receptor signaling through STAT3 and tumor progression in triple-negative breast cancer. 28088463 2018
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker phenotype BEFREE Urokinase plasminogen activator secreted by cancer-associated fibroblasts induces tumor progression via PI3K/AKT and ERK signaling in esophageal squamous cell carcinoma. 28404945 2018
Entrez Id: 6581
Gene Symbol: SLC22A3
SLC22A3
0.100 PosttranslationalModification phenotype BEFREE Upregulation of LncDQ is Associated with Poor Prognosis and Promotes Tumor Progression via Epigenetic Regulation of the EMT Pathway in HCC. 29669339 2018
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.100 Biomarker phenotype BEFREE Placental Growth Factor and Vascular Endothelial Growth Factor Together Regulate Tumour Progression via Increased Vasculature in Cutaneous T-cell Lymphoma. 28119994 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.100 Biomarker phenotype BEFREE Urokinase plasminogen activator secreted by cancer-associated fibroblasts induces tumor progression via PI3K/AKT and ERK signaling in esophageal squamous cell carcinoma. 28404945 2018
Entrez Id: 92140
Gene Symbol: MTDH
MTDH
0.100 AlteredExpression phenotype BEFREE Astrocyte elevated gene-1 (AEG-1), known as an oncogene, is overexpressed in various cancers and implicated in tumor progression and metastasis. 28731152 2018
Entrez Id: 27250
Gene Symbol: PDCD4
PDCD4
0.100 Biomarker phenotype BEFREE Programmed cell death 4 (Pdcd4) is frequently suppressed in tumors of various origins and its suppression correlates with tumor progression. 28853972 2018
Entrez Id: 5594
Gene Symbol: MAPK1
MAPK1
0.100 AlteredExpression phenotype BEFREE HOXB7 promotes tumor progression via bFGF-induced activation of MAPK/ERK pathway and indicated poor prognosis in hepatocellular carcinoma. 28454092 2018