Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.800 GeneticVariation disease UNIPROT
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.800 Biomarker disease HPO
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.800 CausalMutation disease CGI
Entrez Id: 3481
Gene Symbol: IGF2
IGF2 		0.500 Biomarker disease HPO
Entrez Id: 4221
Gene Symbol: MEN1
MEN1 		0.420 Biomarker disease HPO
Entrez Id: 5573
Gene Symbol: PRKAR1A
PRKAR1A 		0.130 Biomarker disease HPO
Entrez Id: 1028
Gene Symbol: CDKN1C
CDKN1C 		0.120 Biomarker disease HPO
Entrez Id: 283120
Gene Symbol: H19
H19 		0.110 Biomarker disease HPO
Entrez Id: 324
Gene Symbol: APC
APC 		0.110 Biomarker disease HPO
Entrez Id: 3784
Gene Symbol: KCNQ1
KCNQ1 		0.100 Biomarker disease HPO
Entrez Id: 10984
Gene Symbol: KCNQ1OT1
KCNQ1OT1 		0.100 Biomarker disease HPO
Entrez Id: 105259599
Gene Symbol: H19-ICR
H19-ICR 		0.100 Biomarker disease HPO
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B 		0.100 Biomarker disease HPO
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B 		0.100 Biomarker disease HPO
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A 		0.100 Biomarker disease HPO
Entrez Id: 1031
Gene Symbol: CDKN2C
CDKN2C 		0.100 Biomarker disease HPO
Entrez Id: 3479
Gene Symbol: IGF1
IGF1 		0.080 Biomarker disease BEFREE <i>IGF-2</i> overexpression is essential for the growth of monoclonal lesions, such as large benign adenomas (ACA) and adrenocortical carcinomas (ACC) and has been found to contribute to tumorigenesis in Beckwith-Wiedemann syndrome. 30069455 2018
Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1 		0.100 AlteredExpression disease BEFREE 2-Chloro-s-triazine herbicides induce aromatase (CYP19) activity in H295R human adrenocortical carcinoma cells: a novel mechanism for estrogenicity? 10746939 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.800 GeneticVariation disease LHGDN 40 children with ACT carried the TP53 R337H mutation; the remaining child with ACT was not tested. 16033918 2006
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.800 GeneticVariation disease BEFREE 40 children with ACT carried the TP53 R337H mutation; the remaining child with ACT was not tested. 16033918 2006
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4 		0.010 AlteredExpression disease BEFREE Adrenal carcinomas showed a significant reduction of the TGFbeta1 mRNA levels but on the contrary Smad 4 mRNA levels were significantly increased. 11196469 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.800 GeneticVariation disease BEFREE Adrenocortical carcinoma (ACC) is recognized to be a component tumor of the Li Fraumeni Syndrome (LFS), a familial cancer predisposition resulting from germline mutations in the p53 tumor-suppressor. p53 activity is tightly regulated by multiple post-translational mechanisms, disruption of which may lead to tumorigenesis. 21930187 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.800 GeneticVariation disease BEFREE Adrenocortical carcinoma (ACC) is a very rare paediatric cancer, and up to 80% of affected children are found to carry germline TP53 mutations. 22233476 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.800 GeneticVariation disease BEFREE Adrenocortical carcinomas (ACCs) are among the most common childhood cancers occurring in infants affected with the Li-Fraumeni and Li- Fraumeni-like (LFS/LFL) syndromes, which are caused by dominant germline mutations in the TP53 gene. 23570263 2013
Entrez Id: 110806263
Gene Symbol: LOC110806263
LOC110806263 		0.020 GeneticVariation disease BEFREE Adrenocortical carcinoma (ACC) is an endocrine tumor for which TERT promoter mutations and telomerase activation have been reported. 29956721 2018