Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.300 Biomarker group CTD_human It is indicated that blood concentrations, liver function, graft weight, and polymorphism in the ABCB1 gene are important factors in tacrolimus-induced neurotoxicity. 12352921 2002
Entrez Id: 116
Gene Symbol: ADCYAP1
ADCYAP1 		0.300 Therapeutic group CTD_human Protective effects of pituitary adenylate cyclase activating polypeptide against neurotoxic agents. 29604313 2018
Entrez Id: 120
Gene Symbol: ADD3
ADD3 		0.300 Biomarker group CTD_human Blood gene expression markers to detect and distinguish target organ toxicity. 19784758 2010
Entrez Id: 147
Gene Symbol: ADRA1B
ADRA1B 		0.300 Biomarker group CTD_human Lack of alpha 1b-adrenergic receptor protects against epileptic seizures. 19125850 2009
Entrez Id: 241
Gene Symbol: ALOX5AP
ALOX5AP 		0.300 Biomarker group CTD_human Blood gene expression markers to detect and distinguish target organ toxicity. 19784758 2010
Entrez Id: 590
Gene Symbol: BCHE
BCHE 		0.300 Therapeutic group CTD_human Post-exposure therapy with recombinant human BuChE following percutaneous VX challenge in guinea-pigs. 21620937 2011
Entrez Id: 598
Gene Symbol: BCL2L1
BCL2L1 		0.300 Biomarker group CTD_human Blood gene expression markers to detect and distinguish target organ toxicity. 19784758 2010
Entrez Id: 836
Gene Symbol: CASP3
CASP3 		0.300 Biomarker group CTD_human It is suggested that Caspase-3 siRNA may reduce the neurotoxicity induced by aluminum to a certain extent. 21972528 2011
Entrez Id: 847
Gene Symbol: CAT
CAT 		0.200 Biomarker group RGD Malondialdehyde and catalase as the serum biomarkers of allyl chloride-induced toxic neuropathy. 16938375 2006
Entrez Id: 885
Gene Symbol: CCK
CCK 		0.300 Biomarker group CTD_human Blood gene expression markers to detect and distinguish target organ toxicity. 19784758 2010
Entrez Id: 915
Gene Symbol: CD3D
CD3D 		0.300 Biomarker group CTD_human Blood gene expression markers to detect and distinguish target organ toxicity. 19784758 2010
Entrez Id: 83716
Gene Symbol: CRISPLD2
CRISPLD2 		0.300 Biomarker group CTD_human Blood gene expression markers to detect and distinguish target organ toxicity. 19784758 2010
Entrez Id: 1577
Gene Symbol: CYP3A5
CYP3A5 		0.300 Therapeutic group CTD_human Eighty-nine percent of CYP3A5 expressers experienced neurotoxicity versus 100% of non-expressers (P = 0.03). 21225912 2011
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.200 Biomarker group RGD Changes in neurotransmitter receptor expression levels in rat brain after 4-week exposure to 1-bromopropane. 19576243 2009
Entrez Id: 54583
Gene Symbol: EGLN1
EGLN1 		0.300 Biomarker group CTD_human Genetic p23 knockdown was found to result in decreases in steady-state PHD2 protein and activity and reduced susceptibility to MPP<sup>+</sup> neurotoxicity. 29471019 2018
Entrez Id: 2043
Gene Symbol: EPHA4
EPHA4 		0.200 Biomarker group RGD Up-regulation of Eph tyrosine kinase receptors after excitotoxic injury in adult hippocampus. 10336070 1999
Entrez Id: 2353
Gene Symbol: FOS
FOS 		0.300 Therapeutic group CTD_human Different patterns of neuronal activation and neurodegeneration in the thalamus and cortex of epilepsy-resistant Proechimys rats versus Wistar rats after pilocarpine-induced protracted seizures. 19220411 2009
Entrez Id: 2570
Gene Symbol: GABRR2
GABRR2 		0.300 Biomarker group CTD_human Blood gene expression markers to detect and distinguish target organ toxicity. 19784758 2010
Entrez Id: 3586
Gene Symbol: IL10
IL10 		0.200 Therapeutic group RGD Dysregulation in myelination mediated by persistent neuroinflammation: possible mechanisms in chemotherapy-related cognitive impairment. 23916895 2014
Entrez Id: 27040
Gene Symbol: LAT
LAT 		0.300 Biomarker group CTD_human Blood gene expression markers to detect and distinguish target organ toxicity. 19784758 2010
Entrez Id: 2475
Gene Symbol: MTOR
MTOR 		0.300 Biomarker group CTD_human The immunosuppressant rapamycin exacerbates neurotoxicity of Abeta peptide. 16955484 2006
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2 		0.300 Therapeutic group CTD_human This outcome is associated with an increased basal resistance, but more so, an enhanced Nrf2 response to lesioning that attenuated the ensuing neurotoxicity. 20211941 2010
Entrez Id: 1728
Gene Symbol: NQO1
NQO1 		0.300 Therapeutic group CTD_human These results support the protective role of DT-diaphorase against aminochrome neurotoxicity in dopaminergic neurons containing neuromelanin and show that Nq6 and Nq7 siRNA are very useful tools to study the role of DT-diaphorase in aminochrome metabolism. 20849151 2010
Entrez Id: 5023
Gene Symbol: P2RX1
P2RX1 		0.300 Biomarker group CTD_human Blood gene expression markers to detect and distinguish target organ toxicity. 19784758 2010
Entrez Id: 5327
Gene Symbol: PLAT
PLAT 		0.300 Biomarker group CTD_human The intranigral injection of tissue plasminogen activator induced blood-brain barrier disruption, inflammatory process and degeneration of the dopaminergic system of the rat. 19442825 2009