Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 100130958
Gene Symbol: SYCE1L
SYCE1L 		0.010 AlteredExpression disease BEFREE MRP2 expression was positive in 53.1% (76/143) of GBCA samples. 23841074 2013
Entrez Id: 6502
Gene Symbol: SKP2
SKP2 		0.010 Biomarker disease BEFREE Skp2-RNAi was transduced into cells of the gallbladder carcinoma cell line GBC-SD, using a lentiviral vector. 23946596 2013
Entrez Id: 604
Gene Symbol: BCL6
BCL6 		0.010 AlteredExpression disease BEFREE BCL6 overexpression is associated with decreased p19 ARF expression and confers an independent prognosticator in gallbladder carcinoma. 24114011 2014
Entrez Id: 29128
Gene Symbol: UHRF1
UHRF1 		0.010 AlteredExpression disease BEFREE UHRF1 depletion upregulated the expression of PML and triggered extrinsic and intrinsic apoptotic pathways by promoting the expression of FasL/FADD, bax, cytosolic cytochrome c, cleaved caspase-8, -9 and -3 and cleaved PRAP and by suppressing bcl-2 expression in GBC-SD and NOZ cells. 24756644 2014
Entrez Id: 2300
Gene Symbol: FOXL1
FOXL1 		0.010 AlteredExpression disease BEFREE FOXL1 was frequently downregulated in GBC tissues and cell lines. 25010679 2014
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA 		0.100 Biomarker disease BEFREE Vascular endothelial growth factor (VEGF)-C is an important lymphangiogenic factor involved in the lymphangiogenesis of gallbladder carcinoma (GBC) and the lymph node metastasis of the tumor. 25154789 2014
Entrez Id: 1192
Gene Symbol: CLIC1
CLIC1 		0.050 AlteredExpression disease BEFREE CLIC1 expression was significantly higher (62.7 %) in gallbladder cancer than in cholelithiasis (21.3 %, p < 0.001). 25227665 2015
Entrez Id: 506
Gene Symbol: ATP5F1B
ATP5F1B 		0.010 Biomarker disease BEFREE ATP5b and β2-microglobulin are predictive markers for the prognosis of patients with gallbladder cancer. 25311765 2015
Entrez Id: 59272
Gene Symbol: ACE2
ACE2 		0.010 AlteredExpression disease BEFREE ACE2 levels were studied in in vivo GBC mouse models subject to ARB treatment. 25663464 2015
Entrez Id: 7439
Gene Symbol: BEST1
BEST1 		0.010 Biomarker disease BEFREE ARB blocked A2-induced GBC cell growth and activated ERK. 25663464 2015
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2 		0.200 Biomarker disease BEFREE HER2/neu blockade is a promising treatment strategy for gallbladder cancer patients with gene amplification and deserves further exploration in a multi-center study. 26022204 2015
Entrez Id: 214
Gene Symbol: ALCAM
ALCAM 		0.010 GeneticVariation disease BEFREE ALCAM Ars1157Crs10511244 (P = 0.0035) haplotype was significantly associated with GBC susceptibility. 26318430 2016
Entrez Id: 4282
Gene Symbol: MIF
MIF 		0.010 Biomarker disease BEFREE Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer. 26530123 2015
Entrez Id: 1236
Gene Symbol: CCR7
CCR7 		0.010 AlteredExpression disease BEFREE CCR7 was highly expressed in GBC samples. 27009073 2016
Entrez Id: 5315
Gene Symbol: PKM
PKM 		0.030 AlteredExpression disease BEFREE PKM2 mRNA level were significantly high in gallbladder cancer tissues than in adjacent noncancerous tissues (P < 0.001). 27283076 2016
Entrez Id: 112441427
Gene Symbol: GCASPC
GCASPC 		0.010 AlteredExpression disease BEFREE GCASPC levels were significantly lower in gallbladder cancer than adjacent nontumor tissues and were associated with tumor size, American Joint Committee on Cancer tumor stage, and patient outcomes. 27450454 2016
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.100 GeneticVariation disease BEFREE KRAS point mutations were detected in intrahepatic CC (7.6%), common bile duct cancer (13.3%), and gallbladder carcinoma (3.3%). 27745798 2017
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.020 Biomarker disease BEFREE BRAF gene amplifications were demonstrated in intrahepatic CC (4.3%), common bile duct cancer (3.3%), and gallbladder cancer (5%). 27745798 2017
Entrez Id: 407035
Gene Symbol: MIR31
MIR31 		0.010 Biomarker disease BEFREE MiR-31 regulates the cisplatin resistance by targeting Src in gallbladder cancer. 27825112 2016
Entrez Id: 55000
Gene Symbol: TUG1
TUG1 		0.010 AlteredExpression disease BEFREE TUG1 expression was significantly overexpressed in GBC tissues. 28178615 2017
Entrez Id: 7178
Gene Symbol: TPT1
TPT1 		0.020 AlteredExpression disease BEFREE TCTP is aberrantly expressed in gallbladder cancer patients and associated with metastasis and a poor prognosis. 28506239 2017
Entrez Id: 4513
Gene Symbol: COX2
COX2 		0.030 AlteredExpression disease BEFREE COX-2 and p-ERK1/2 protein expression levels were found to be significantly elevated in GBC tissues as well as in GBC-SD and NOZ cells. 28521485 2017
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12 		0.020 AlteredExpression disease BEFREE COX-2 and p-ERK1/2 protein expression levels were found to be significantly elevated in GBC tissues as well as in GBC-SD and NOZ cells. 28521485 2017
Entrez Id: 406935
Gene Symbol: MIR143
MIR143 		0.030 Biomarker disease BEFREE miR-143-5p was first found significantly reduced in GBC tissues compared with corresponding noncancerous gallbladder tissues. 28803245 2017
Entrez Id: 1192
Gene Symbol: CLIC1
CLIC1 		0.050 Biomarker disease BEFREE Chloride intracellular channel 1 (CLIC1) was previously reported to be an effective biomarker for predicting the prognosis of GBC. 28944858 2017