Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE Serotonin and dopamine transporter PET changes in the premotor phase of LRRK2 parkinsonism: cross-sectional studies. 28336296 2017
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 Biomarker group BEFREE EDS and RBD were always reported to start after the onset of parkinsonism in LRRK2-PD. 26177462 2016
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 Biomarker group CTD_human Methylmercury can induce Parkinson's-like neurotoxicity similar to 1-methyl-4- phenylpyridinium: a genomic and proteomic analysis on MN9D dopaminergic neuron cells. 26558463 2016
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE The present study also establishes that G2019S mutation leads to a reduction in lysosomal pH and increased expression of the lysosomal ATPase ATP13A2, a gene linked to a parkinsonian syndrome (Kufor-Rakeb syndrome), in brain samples from mouse and human LRRK2 G2019S carriers. 26251043 2016
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 Biomarker group BEFREE It is also clear that LRRK2 interacts, either physically or genetically, with several other important proteins implicated in PD, suggesting that LRRK2 may be a central player in the pathways that underlie parkinsonism. 26008812 2016
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of genetic Parkinsonism. 26536050 2016
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE Prediction of the repeat domain structures and impact of parkinsonism-associated variations on structure and function of all functional domains of leucine-rich repeat kinase 2 (LRRK2). 24470158 2015
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 PosttranslationalModification group BEFREE The role of the LRRK2 gene in Parkinsonism. 25391693 2015
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE LRRK2 mutations were identified in 40 of 2523 PD patients (1.6%) and not in other primary parkinsonian syndromes. 24816003 2015
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 Biomarker group CTD_human G2019S LRRK2 mutant fibroblasts from Parkinson's disease patients show increased sensitivity to neurotoxin 1-methyl-4-phenylpyridinium dependent of autophagy. 25017139 2014
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE Comparative study of Parkinson's disease and leucine-rich repeat kinase 2 p.G2019S parkinsonism. 24355527 2014
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE Sustained response to deep brain stimulation in LRRK2 parkinsonism with the Y1699C mutation. 23938256 2014
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE Leucine-rich repeat kinase 2 (LRRK2) mutation is the most common cause of genetic-related parkinsonism and is usually associated with Lewy body pathology; however, tau, α-synuclein, and ubiquitin pathologies have also been reported. 23664753 2014
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE Variants of the MAPT gene have been suggested to be associated with Parkinson's disease (PD) and to modify the risk for leucine-rich repeat kinase 2 (LRRK2) Parkinsonism. 24559644 2014
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE In addition, we found that the proband and his mother carried the G2385R variant of the LRRK2, a strong risk factor for PD in Asians and the rare V1450I variant, although only the proband showed symptoms of parkinsonism.No mutations were found in parkin. 23124679 2013
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE Twelve- to sixteen-month-old (G2019S) LRRK2 transgenic mice prepared by us displayed progressive degeneration of substantia nigra pars compacta (SNpc) dopaminergic neurons and parkinsonism phenotypes of motor dysfunction. 22539006 2013
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 Biomarker group BEFREE These results not only represent the largest replication data affirming the association between PD and all the six genes/loci in Chinese, but for the first time suggest that multiple PD-associated genetic factors modify both the penetrance and AAO of LRRK2 parkinsonism. 22658533 2013
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE Prior studies causally linked mutations in SNCA, MAPT, and LRRK2 genes with familial Parkinsonism. 23507417 2013
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 Biomarker group CTD_human Low doses of paraquat and polyphenols prolong life span and locomotor activity in knock-down parkin Drosophila melanogaster exposed to oxidative stress stimuli: implication in autosomal recessive juvenile parkinsonism. 23046578 2013
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 Biomarker group BEFREE Cerebral pathological and compensatory mechanisms in the premotor phase of leucine-rich repeat kinase 2 parkinsonism. 23250886 2013
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 Biomarker group BEFREE Our results further support that LRRK2 variants are an independent genetic risk factor for typical PD, but BDNF variants can greatly increase LRRK2-induced risk for patients with an onset age of older than 60 indicating an additive effect between the 2 genes, which might aid in studying the mechanism underlying LRRK2 parkinsonism and developing potential therapeutic strategies. 21924942 2012
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE LRRK2 p.S1761R carriers developed levodopa-responsive asymmetrical parkinsonism, with variable age at onset (range: 37-72 years) suggesting age-dependent penetrance. 22038903 2012
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE A series of 106 patients with isolated or familial Parkinsonism underwent clinical evaluation and genetic testing for the LRRK2 G2019S mutation which was identified in 34/106 patients (32%). 20933457 2011
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 Biomarker group BEFREE Our report adds evidence that patients with LRRK2 monogenetic Parkinsonism are well suited candidates for DBS treatment and may indicate a potential genetic predictor for positive long-term effect of STN-DBS treatment. 20177695 2011
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE Gender differences in the risk of familial parkinsonism: beyond LRRK2? 21511009 2011