×
Entrez Id:
7225
Gene Symbol:
TRPC6
TRPC6
0.400
Biomarker
group
BEFREE
These data suggest that knockout of TRPC6 in Akita mice promotes insulin resistance and exacerbates glomerular disease independent of hyperglycemia.
30665571
2019
×
Entrez Id:
7225
Gene Symbol:
TRPC6
TRPC6
0.400
AlteredExpression
group
BEFREE
Several studies have identified gain-of-function mutations of <i>TRPC6</i> and report induced expression and enhanced channel activity of TRPC6 in association with glomerular diseases .
28877958
2018
×
Entrez Id:
7225
Gene Symbol:
TRPC6
TRPC6
0.400
Biomarker
group
BEFREE
Increased calcium ion entry through the TRPC6 channel has been associated with the pathogenesis of heart and glomerular diseases , but its role in renal interstitial fibrosis is unknown.
27979597
2017
×
Entrez Id:
7225
Gene Symbol:
TRPC6
TRPC6
0.400
AlteredExpression
group
BEFREE
Transient receptor potential channel C6 (TRPC6 ) gain-of-function mutations and increased TRPC6 expression in podocytes induce glomerular injury and proteinuria.
27895156
2017
×
Entrez Id:
7225
Gene Symbol:
TRPC6
TRPC6
0.400
Biomarker
group
BEFREE
Therefore, we provide evidence demonstrating the critical role of Ang II/TRPC6 axis in the control of glomeruli function, which is likely important for the development of glomerular diseases .
28331185
2017
×
Entrez Id:
7225
Gene Symbol:
TRPC6
TRPC6
0.400
Biomarker
group
BEFREE
GPCRs coupled to Gq signaling activate TRPC6 , suggesting that Gq-dependent TRPC6 activation underlies glomerular diseases .
25844902
2015
×
Entrez Id:
7225
Gene Symbol:
TRPC6
TRPC6
0.400
Biomarker
group
BEFREE
Transient receptor potential channel 6 (TRPC6 ) protects podocytes during complement-mediated glomerular disease .
24194522
2013
×
Entrez Id:
7225
Gene Symbol:
TRPC6
TRPC6
0.400
AlteredExpression
group
BEFREE
Vitamin D down-regulates TRPC6 expression in podocyte injury and proteinuric glomerular disease .
23385000
2013
×
Entrez Id:
7225
Gene Symbol:
TRPC6
TRPC6
0.400
AlteredExpression
group
BEFREE
Angiotensin II (AngII) is a key contributor to glomerular disease and may regulate TRPC6 expression in nonrenal cells.
21839714
2011
×
Entrez Id:
7225
Gene Symbol:
TRPC6
TRPC6
0.400
AlteredExpression
group
BEFREE
In addition, acquired glomerular diseases are associated with increased expression levels of TRPC6 .
20877463
2010
×
Entrez Id:
7225
Gene Symbol:
TRPC6
TRPC6
0.400
Biomarker
group
BEFREE
It seems that TRPC6 is a gene with a very variable penetrance that may contribute to glomerular diseases in a multi-hit setting.
19458060
2009
×
Entrez Id:
7225
Gene Symbol:
TRPC6
TRPC6
0.400
Biomarker
group
GENOMICS_ENGLAND