Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4352
Gene Symbol: MPL
MPL 		0.100 Biomarker disease BEFREE Eltrombopag (ELT) is a thrombopoietin receptor activator that has shown efficacy in chronic immune thrombocytopenia. 31205222 2020
Entrez Id: 4352
Gene Symbol: MPL
MPL 		0.100 Biomarker disease BEFREE Markers of endothelial cell activation and neutrophil extracellular traps are elevated in immune thrombocytopenia but are not enhanced by thrombopoietin receptor agonists. 31805421 2020
Entrez Id: 4352
Gene Symbol: MPL
MPL 		0.100 Biomarker disease BEFREE Romiplostim (Nplate<sup>®</sup>), a thrombopoietin receptor agonist, is the first FDA-approved thrombopoiesis-stimulating protein for the treatment of low platelet (PLT) counts in adults with chronic immune thrombocytopenia. 31021662 2020
Entrez Id: 4352
Gene Symbol: MPL
MPL 		0.100 Biomarker disease BEFREE Increased microvesicle-associated thrombin generation in patients with immune thrombocytopenia after initiation of thrombopoietin receptor agonists. 31280643 2020
Entrez Id: 4352
Gene Symbol: MPL
MPL 		0.100 Biomarker disease BEFREE The thrombopoietin receptor (TPOR) agonist romiplostim (RP) is a therapeutic agent for immune thrombocytopenia and has potential to respond to such victims. 30926566 2019
Entrez Id: 7066
Gene Symbol: THPO
THPO 		0.100 Biomarker disease BEFREE Romiplostim is a thrombopoietin-mimetic peptibody for adult refractory chronic immune thrombocytopenia (ITP). 30758874 2019
Entrez Id: 4352
Gene Symbol: MPL
MPL 		0.100 Biomarker disease BEFREE Romiplostim is a thrombopoietin receptor agonist approved for the treatment of immune thrombocytopenia purpura. 29357781 2019
Entrez Id: 4352
Gene Symbol: MPL
MPL 		0.100 Biomarker disease BEFREE Effect of thrombopoietin receptor agonists on markers of coagulation and P-selectin in patients with immune thrombocytopenia. 29215956 2019
Entrez Id: 7066
Gene Symbol: THPO
THPO 		0.100 Biomarker disease BEFREE Effect of recombinant human thrombopoietin on immune thrombocytopenia in pregnancy in a murine model. 30572253 2019
Entrez Id: 7066
Gene Symbol: THPO
THPO 		0.100 Biomarker disease BEFREE Both TPO receptor agonists have been approved worldwide for the treatment of children and adults with chronic immune thrombocytopenia. 31836033 2019
Entrez Id: 4352
Gene Symbol: MPL
MPL 		0.100 Biomarker disease BEFREE Thrombopoietin Receptor Agonists: Eltrombopag and Romiplostim for the Treatment of Chronic Immune Thrombocytopenia Purpura. 30880797 2019
Entrez Id: 4352
Gene Symbol: MPL
MPL 		0.100 Biomarker disease BEFREE Switching thrombopoietin receptor agonist treatments in patients with primary immune thrombocytopenia. 31156798 2019
Entrez Id: 4352
Gene Symbol: MPL
MPL 		0.100 Biomarker disease BEFREE Immune thrombocytopenia is associated with persistently deranged fibrosis-related seromarker profiles but low bone marrow fibrosis grades: A 2-year observational study on thrombopoietin receptor agonist treatment. 29293383 2019
Entrez Id: 4352
Gene Symbol: MPL
MPL 		0.100 Biomarker disease BEFREE Romiplostim is a thrombopoietin receptor agonist recommended as a second-line therapy for immune thrombocytopenia. 29298625 2019
Entrez Id: 4352
Gene Symbol: MPL
MPL 		0.100 Biomarker disease BEFREE Thrombopoietin receptor agonist switch in children with persistent and chronic severe immune thrombocytopenia: A retrospective analysis in a large tertiary center. 30854783 2019
Entrez Id: 4352
Gene Symbol: MPL
MPL 		0.100 Biomarker disease BEFREE Optimal use of thrombopoietin receptor agonists in immune thrombocytopenia. 31007886 2019
Entrez Id: 4352
Gene Symbol: MPL
MPL 		0.100 Biomarker disease BEFREE Tapering and discontinuation of thrombopoietin receptor agonists in immune thrombocytopenia: Real-world recommendations. 31818701 2019
Entrez Id: 4352
Gene Symbol: MPL
MPL 		0.100 Biomarker disease BEFREE The thrombopoietin receptor agonist romiplostim is approved for second-line use in chronic immune thrombocytopenia (ITP), but its effects in patients with ITP for ≤1 year are not well characterized. 30793285 2019
Entrez Id: 4352
Gene Symbol: MPL
MPL 		0.100 Biomarker disease BEFREE Deciphering predictive factors for choice of thrombopoietin receptor agonist, treatment free responses, and thrombotic events in immune thrombocytopenia. 31723222 2019
Entrez Id: 7066
Gene Symbol: THPO
THPO 		0.100 Biomarker disease BEFREE Autoantibodies to thrombopoietin and the thrombopoietin receptor in patients with immune thrombocytopenia. 29532903 2018
Entrez Id: 7066
Gene Symbol: THPO
THPO 		0.100 Biomarker disease BEFREE Treatment characteristics, efficacy and safety of thrombopoietin analogues in routine management of primary immune thrombocytopenia. 29738335 2018
Entrez Id: 4352
Gene Symbol: MPL
MPL 		0.100 Biomarker disease BEFREE A decision framework for treating chronic immune thrombocytopenia with thrombopoietin receptor agonists. 29848048 2018
Entrez Id: 7066
Gene Symbol: THPO
THPO 		0.100 AlteredExpression disease BEFREE Thrombopoietin and its receptor expression in pediatric patients with chronic immune thrombocytopenia. 29313460 2018
Entrez Id: 7066
Gene Symbol: THPO
THPO 		0.100 Biomarker disease BEFREE Icaritin Provokes Serum Thrombopoietin and Downregulates Thrombopoietin/MPL of the Bone Marrow in a Mouse Model of Immune Thrombocytopenia. 30224899 2018
Entrez Id: 4352
Gene Symbol: MPL
MPL 		0.100 Biomarker disease BEFREE Thrombopoietin receptor agonists in patients with persistent or chronic immune thrombocytopenia. 29243329 2018