Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10603
Gene Symbol: SH2B2
SH2B2 		0.010 Biomarker disease BEFREE Other non-thrombotic APS manifestations were chronic ulcers in lower extremities and severe thrombocytopenia. 28216071 2017
Entrez Id: 4087
Gene Symbol: SMAD2
SMAD2 		0.010 AlteredExpression disease BEFREE The model mice had a thicker epidermis and impaired transforming growth factor-β (TGF-β) signaling followed by SMAD2 down-regulation, which causes epidermal hyperplasia in chronic ulcers. 28687753 2017
Entrez Id: 354
Gene Symbol: KLK3
KLK3 		0.010 Biomarker disease BEFREE Other non-thrombotic APS manifestations were chronic ulcers in lower extremities and severe thrombocytopenia. 28216071 2017
Entrez Id: 7097
Gene Symbol: TLR2
TLR2 		0.010 AlteredExpression disease BEFREE TLR2 down regulation in wounds of T2DM patients compared to non diabetic patients may lead to development of non healing chronic ulcers in them. 25541252 2015
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.010 Biomarker disease BEFREE The present study evaluates the effects of extract of Musa sapientum fruit (MSE) on ulcer index, blood glucose level and gastric mucosal cytokines, TNF-α and IL-1β and growth factor, TGF-α (affected in diabetes and chronic ulcer) in acetic acid (AA)-induced gastric ulcer (GU) in diabetic (DR) rat. 24192345 2013
Entrez Id: 7039
Gene Symbol: TGFA
TGFA 		0.010 Biomarker disease BEFREE The present study evaluates the effects of extract of Musa sapientum fruit (MSE) on ulcer index, blood glucose level and gastric mucosal cytokines, TNF-α and IL-1β and growth factor, TGF-α (affected in diabetes and chronic ulcer) in acetic acid (AA)-induced gastric ulcer (GU) in diabetic (DR) rat. 24192345 2013
Entrez Id: 3553
Gene Symbol: IL1B
IL1B 		0.010 Biomarker disease BEFREE The present study evaluates the effects of extract of Musa sapientum fruit (MSE) on ulcer index, blood glucose level and gastric mucosal cytokines, TNF-α and IL-1β and growth factor, TGF-α (affected in diabetes and chronic ulcer) in acetic acid (AA)-induced gastric ulcer (GU) in diabetic (DR) rat. 24192345 2013
Entrez Id: 8038
Gene Symbol: ADAM12
ADAM12 		0.010 AlteredExpression disease BEFREE The increase in ADAM12 expression in chronic ulcers was confirmed by quantitative real-time polymerase chain reaction (RT-PCR). 18604515 2008
Entrez Id: 1437
Gene Symbol: CSF2
CSF2 		0.010 Biomarker disease BEFREE Granulocyte/macrophage colony-stimulating factor treatment of human chronic ulcers promotes angiogenesis associated with de novo vascular endothelial growth factor transcription in the ulcer bed. 16403091 2006
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA 		0.010 Biomarker disease BEFREE Granulocyte/macrophage colony-stimulating factor treatment of human chronic ulcers promotes angiogenesis associated with de novo vascular endothelial growth factor transcription in the ulcer bed. 16403091 2006
Entrez Id: 7077
Gene Symbol: TIMP2
TIMP2 		0.010 AlteredExpression disease BEFREE Lack of TIMP-2 near the migrating epithelial wound edges might contribute to uncontrolled activity of MMP-2 in chronic ulcers. 10414498 1999
Entrez Id: 4313
Gene Symbol: MMP2
MMP2 		0.010 AlteredExpression disease BEFREE Lack of TIMP-2 near the migrating epithelial wound edges might contribute to uncontrolled activity of MMP-2 in chronic ulcers. 10414498 1999
Entrez Id: 7079
Gene Symbol: TIMP4
TIMP4 		0.010 Biomarker disease BEFREE Occasional staining for TIMP-4 protein was detected in stromal cells of chronic ulcers near blood vessels. 10414498 1999
Entrez Id: 4312
Gene Symbol: MMP1
MMP1 		0.010 Biomarker disease BEFREE Distinct populations of stromal cells express collagenase-3 (MMP-13) and collagenase-1 (MMP-1) in chronic ulcers but not in normally healing wounds. 9204962 1997
Entrez Id: 4322
Gene Symbol: MMP13
MMP13 		0.010 Biomarker disease BEFREE Distinct populations of stromal cells express collagenase-3 (MMP-13) and collagenase-1 (MMP-1) in chronic ulcers but not in normally healing wounds. 9204962 1997