|
CDKN2B-AS1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The association of rs2157719 (CDKN2B-AS1) with the POAG phenotype corroborates previously published results, reinforcing the importance of this variant in POAG etiology.
|
29111846 |
2018 |
|
CDKN2B-AS1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We did, however, detect a significant association between POAG risk and local African genetic ancestry at CDKN2B-AS1, where on average cases were of 90% African descent compared with controls at 58% (p = 2 × 10<sup>- 6</sup>).
|
30255811 |
2018 |
|
CDKN2B-AS1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We confirmed that there was a significant association of the CDKN2B(AS1) gene to POAG.
|
28472212 |
2017 |
|
CDKN2B-AS1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Many genome-wide association studies have identified common single nucleotide polymorphisms (SNPs) at the 9p21 glaucoma locus (CDKN2B/CDKN2B-AS1) to be significantly associated with primary open-angle glaucoma (POAG), with association being stronger in normal tension glaucoma (NTG) and advanced glaucoma.
|
27367510 |
2016 |
|
CDKN2B-AS1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The SNPs rs4656461 and rs7555523 at TMCO1, rs523096 and rs2157719 at CDKN2B-AS1, as well as rs33912345 and rs10483727 at SIX1/SIX6 showed statistically significant association with POAG.
|
25711633 |
2015 |
|
CDKN2B-AS1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recent genome-wide association studies revealed a large number of susceptibility gene variants associated with both POAG (e.g., CDKN2BAS, CAV1/CAV2, and ATOH7) and PACG (e.g., PLEKHA7 and COL11A1 PCMTD1-ST18).
|
26497787 |
2015 |
|
CDKN2B-AS1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Apart from confirming strong evidence of association at CDKN2B-AS1 (rs2157719 [G], odds ratio [OR] = 0.71, P = 2.81 × 10(-33)), we observed one SNP showing significant association to POAG (CDC7-TGFBR3 rs1192415, ORG-allele = 1.13, Pmeta = 1.60 × 10(-8)).
|
25861811 |
2015 |
|
CDKN2B-AS1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recent genome-wide association studies (GWAS) reported associations with IOP at TMCO1 and GAS7, and with primary open-angle glaucoma (POAG) at CDKN2B-AS1, CAV1/CAV2, and SIX1/SIX6.
|
24002674 |
2014 |
|
CDKN2B-AS1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
It has recently been shown that there are highly significant associations for common single nucleotide polymorphisms (SNPs) near the CDKN2B-AS1 gene region at the 9p21 locus with primary open angle glaucoma (POAG), a leading cause of irreversible blindness.
|
24069379 |
2013 |
|
CDKN2B-AS1
|
0.400 |
Biomarker
|
disease |
BEFREE |
Alleles of CDKN2B-AS1 SNPs, which influence risk of developing POAG, also modulate optic nerve degeneration among POAG patients, underscoring the role of CDKN2B-AS1 in POAG.
|
23111177 |
2013 |
|
CDKN2B-AS1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, we successfully identified POAG-associated variants in the CDKN2B-AS1 locus using a Japanese population, i.e., variants originally reported as being associated with the Caucasian population.
|
22428042 |
2012 |
|
CDKN2B-AS1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The overall meta-analysis of the GLAUGEN and NEIGHBOR dataset results (3,146 cases and 3,487 controls) identified significant associations between two loci and POAG: the CDKN2BAS region on 9p21 (rs2157719 [G], OR = 0.69 [95%CI 0.63-0.75], p = 1.86×10⁻¹⁸), and the SIX1/SIX6 region on chromosome 14q23 (rs10483727 [A], OR = 1.32 [95%CI 1.21-1.43], p = 3.87×10⁻¹¹).
|
22570617 |
2012 |
|
CDKN2B-AS1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation at the 9p21 locus encompassing the CDKN2B-AS1, CDKN2A, and CDKN2B genes has been associated with primary open-angle glaucoma (POAG) in several independent studies.
|
22521085 |
2012 |
|
CDKN2B-AS1
|
0.400 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1.
|
21532571 |
2011 |