×
Entrez Id:
9098
Gene Symbol:
USP6
USP6
0.400
AlteredExpression
disease
BEFREE
To describe two cases of intra-articular nodular fasciitis (NF ) which developed within the knee joint and were associated with the expression of the MYH9-USP6 gene fusion.
30611632
2019
×
Entrez Id:
9098
Gene Symbol:
USP6
USP6
0.400
GeneticVariation
disease
BEFREE
Malignant transformation of NF has been reported rarely as a single case associated with the PPP6R3-USP6 fusion.
31538390
2019
×
Entrez Id:
9098
Gene Symbol:
USP6
USP6
0.400
GeneticVariation
disease
BEFREE
USP6 rearrangements have been identified as a consistent genetic driving event in aneurysmal bone cyst and nodular fasciitis .
29661729
2018
×
Entrez Id:
9098
Gene Symbol:
USP6
USP6
0.400
GeneticVariation
disease
BEFREE
Despite overlap in histological and immunohistochemical features between pseudosarcomatous myofibroblastic proliferation and nodular fasciitis, these tumours lack the recently recognised USP6 rearrangements that occur in nodular fasciitis , as well as alternative fusions found in ALK-negative inflammatory myofibroblastic tumours.
29617048
2018
×
Entrez Id:
9098
Gene Symbol:
USP6
USP6
0.400
Biomarker
disease
BEFREE
These findings further support the oncogenic role of the USP6 protease in mesenchymal neoplasia and expand the biologic potential of NF .
27113271
2016
×
Entrez Id:
9098
Gene Symbol:
USP6
USP6
0.400
Biomarker
disease
BEFREE
Previously, it was observed that USP6 is sufficient to drive formation of tumors mimicking ABC and nodular fasciitis , and that it functions through JAK1/STAT3 signaling.
30131449
2018
×
Entrez Id:
9098
Gene Symbol:
USP6
USP6
0.400
AlteredExpression
disease
BEFREE
Ectopic expression of USP6 is known to drive formation of tumors, which recapitulate key features of ABC and nodular fasciitis ; however, the identity of USP6 's relevant substrates has been obscure.
27440725
2016
×
Entrez Id:
9098
Gene Symbol:
USP6
USP6
0.400
GeneticVariation
disease
BEFREE
FISH analysis revealed USP6 translocation in 74.4% of NF cases.
29623468
2018
×
Entrez Id:
9098
Gene Symbol:
USP6
USP6
0.400
Biomarker
disease
BEFREE
USP6 -induced neoplasms: the biologic spectrum of aneurysmal bone cyst and nodular fasciitis .
23769422
2014
×
Entrez Id:
9098
Gene Symbol:
USP6
USP6
0.400
Biomarker
disease
BEFREE
Xenografts of cells overexpressing USP6 in nude mice exhibited clinical and histological features similar to human NF .
21826056
2011
×
Entrez Id:
9098
Gene Symbol:
USP6
USP6
0.400
Biomarker
disease
BEFREE
USP6 activation in nodular fasciitis by promoter-swapping gene fusions.
28752842
2017
×
Entrez Id:
9098
Gene Symbol:
USP6
USP6
0.400
FusionGene
disease
ORPHANET
Xenografts of cells overexpressing USP6 in nude mice exhibited clinical and histological features similar to human NF .
21826056
2011
×
Entrez Id:
9098
Gene Symbol:
USP6
USP6
0.400
Biomarker
disease
BEFREE
Indeed, it revealed COL1A1 and SEC31A as novel fusion partners for USP6 in nodular fasciitis .
30139549
2018
×
Entrez Id:
9098
Gene Symbol:
USP6
USP6
0.400
Biomarker
disease
BEFREE
USP6 FISH is a useful ancillary test in cases where nodular fasciitis is a potential diagnostic consideration.
27271298
2016
×
Entrez Id:
4627
Gene Symbol:
MYH9
MYH9
0.320
AlteredExpression
disease
BEFREE
To describe two cases of intra-articular nodular fasciitis (NF ) which developed within the knee joint and were associated with the expression of the MYH9 -USP6 gene fusion.
30611632
2019
×
Entrez Id:
4627
Gene Symbol:
MYH9
MYH9
0.320
FusionGene
disease
ORPHANET
Nodular fasciitis : a novel model of transient neoplasia induced by MYH9 -USP6 gene fusion.
21826056
2011
×
Entrez Id:
4627
Gene Symbol:
MYH9
MYH9
0.320
Biomarker
disease
BEFREE
The characteristic gene fusion containing the USP6 gene is a genetic hallmark of NF and MYH9 -USP6 is the most frequent fusion, suggesting that NF is not a reactive condition but a neoplastic disease.
31538390
2019
×
Entrez Id:
55291
Gene Symbol:
PPP6R3
PPP6R3
0.020
GeneticVariation
disease
BEFREE
Malignant transformation of NF has been reported rarely as a single case associated with the PPP6R3 -USP6 fusion.
31538390
2019
×
Entrez Id:
55291
Gene Symbol:
PPP6R3
PPP6R3
0.020
Biomarker
disease
BEFREE
PPP6R3 -USP6 amplification: Novel oncogenic mechanism in malignant nodular fasciitis .
27113271
2016
×
Entrez Id:
7291
Gene Symbol:
TWIST1
TWIST1
0.010
AlteredExpression
disease
BEFREE
Differentially expressed transcripts (89 clones displaying increased expression in DTs and 246 clones displaying increased expression in NF ) included genes encoding several receptor and non-receptor tyrosine kinases (EPHB3, PTPRF, GNAZ, SYK, LYN, EPHA4, BIRC3), transcription factors (TWIST1 , PITX2, EYA2, OAS1, MITF, TCF20), and members of the Wnt signalling pathway (AXIN2, WISP1, SFRP).
16440290
2006
×
Entrez Id:
8313
Gene Symbol:
AXIN2
AXIN2
0.010
AlteredExpression
disease
BEFREE
Differentially expressed transcripts (89 clones displaying increased expression in DTs and 246 clones displaying increased expression in NF ) included genes encoding several receptor and non-receptor tyrosine kinases (EPHB3, PTPRF, GNAZ, SYK, LYN, EPHA4, BIRC3), transcription factors (TWIST1, PITX2, EYA2, OAS1, MITF, TCF20), and members of the Wnt signalling pathway (AXIN2 , WISP1, SFRP).
16440290
2006
×
Entrez Id:
4286
Gene Symbol:
MITF
MITF
0.010
AlteredExpression
disease
BEFREE
Differentially expressed transcripts (89 clones displaying increased expression in DTs and 246 clones displaying increased expression in NF ) included genes encoding several receptor and non-receptor tyrosine kinases (EPHB3, PTPRF, GNAZ, SYK, LYN, EPHA4, BIRC3), transcription factors (TWIST1, PITX2, EYA2, OAS1, MITF , TCF20), and members of the Wnt signalling pathway (AXIN2, WISP1, SFRP).
16440290
2006
×
Entrez Id:
6942
Gene Symbol:
TCF20
TCF20
0.010
AlteredExpression
disease
BEFREE
Differentially expressed transcripts (89 clones displaying increased expression in DTs and 246 clones displaying increased expression in NF ) included genes encoding several receptor and non-receptor tyrosine kinases (EPHB3, PTPRF, GNAZ, SYK, LYN, EPHA4, BIRC3), transcription factors (TWIST1, PITX2, EYA2, OAS1, MITF, TCF20 ), and members of the Wnt signalling pathway (AXIN2, WISP1, SFRP).
16440290
2006
×
Entrez Id:
2252
Gene Symbol:
FGF7
FGF7
0.010
Biomarker
disease
BEFREE
One of the genes, the keratinocyte growth factor or fibroblast growth factor 7 (KGF or FGF7 ) was mapped to the 15q22 region, which was involved in a cytogenetic rearrangement in one case of nodular fasciitis .
12606136
2003
×
Entrez Id:
22872
Gene Symbol:
SEC31A
SEC31A
0.010
Biomarker
disease
BEFREE
Indeed, it revealed COL1A1 and SEC31A as novel fusion partners for USP6 in nodular fasciitis .
30139549
2018