Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.010 AlteredExpression disease BEFREE In this study we analysed by immunohistochemistry the expression of p53 protein in 14 malignant fibrous histocytomas (MFHs), 22 other types of sarcoma (eight leiomyosarcomas, four rhabdomyosarcomas, four liposarcomas, two fibrosarcomas, two chondrosarcomas, one malignant schwannoma, and one dermatofibrosarcoma protuberans), and 25 non-malignant mesenchymal lesions (eight dermatofibromas, four cases of nodular fasciitis, three leiomyomas, three fibromatoses, two epithelioid.leiomyomas, two neurofibromas, one schwannoma, one myositis ossificans, and one giant cell tumour of tendon sheath). 1333524 1992
Entrez Id: 2252
Gene Symbol: FGF7
FGF7 		0.010 Biomarker disease BEFREE One of the genes, the keratinocyte growth factor or fibroblast growth factor 7 (KGF or FGF7) was mapped to the 15q22 region, which was involved in a cytogenetic rearrangement in one case of nodular fasciitis. 12606136 2003
Entrez Id: 7291
Gene Symbol: TWIST1
TWIST1 		0.010 AlteredExpression disease BEFREE Differentially expressed transcripts (89 clones displaying increased expression in DTs and 246 clones displaying increased expression in NF) included genes encoding several receptor and non-receptor tyrosine kinases (EPHB3, PTPRF, GNAZ, SYK, LYN, EPHA4, BIRC3), transcription factors (TWIST1, PITX2, EYA2, OAS1, MITF, TCF20), and members of the Wnt signalling pathway (AXIN2, WISP1, SFRP). 16440290 2006
Entrez Id: 8313
Gene Symbol: AXIN2
AXIN2 		0.010 AlteredExpression disease BEFREE Differentially expressed transcripts (89 clones displaying increased expression in DTs and 246 clones displaying increased expression in NF) included genes encoding several receptor and non-receptor tyrosine kinases (EPHB3, PTPRF, GNAZ, SYK, LYN, EPHA4, BIRC3), transcription factors (TWIST1, PITX2, EYA2, OAS1, MITF, TCF20), and members of the Wnt signalling pathway (AXIN2, WISP1, SFRP). 16440290 2006
Entrez Id: 4286
Gene Symbol: MITF
MITF 		0.010 AlteredExpression disease BEFREE Differentially expressed transcripts (89 clones displaying increased expression in DTs and 246 clones displaying increased expression in NF) included genes encoding several receptor and non-receptor tyrosine kinases (EPHB3, PTPRF, GNAZ, SYK, LYN, EPHA4, BIRC3), transcription factors (TWIST1, PITX2, EYA2, OAS1, MITF, TCF20), and members of the Wnt signalling pathway (AXIN2, WISP1, SFRP). 16440290 2006
Entrez Id: 6942
Gene Symbol: TCF20
TCF20 		0.010 AlteredExpression disease BEFREE Differentially expressed transcripts (89 clones displaying increased expression in DTs and 246 clones displaying increased expression in NF) included genes encoding several receptor and non-receptor tyrosine kinases (EPHB3, PTPRF, GNAZ, SYK, LYN, EPHA4, BIRC3), transcription factors (TWIST1, PITX2, EYA2, OAS1, MITF, TCF20), and members of the Wnt signalling pathway (AXIN2, WISP1, SFRP). 16440290 2006
Entrez Id: 4938
Gene Symbol: OAS1
OAS1 		0.010 AlteredExpression disease BEFREE Differentially expressed transcripts (89 clones displaying increased expression in DTs and 246 clones displaying increased expression in NF) included genes encoding several receptor and non-receptor tyrosine kinases (EPHB3, PTPRF, GNAZ, SYK, LYN, EPHA4, BIRC3), transcription factors (TWIST1, PITX2, EYA2, OAS1, MITF, TCF20), and members of the Wnt signalling pathway (AXIN2, WISP1, SFRP). 16440290 2006
Entrez Id: 5308
Gene Symbol: PITX2
PITX2 		0.010 AlteredExpression disease BEFREE Differentially expressed transcripts (89 clones displaying increased expression in DTs and 246 clones displaying increased expression in NF) included genes encoding several receptor and non-receptor tyrosine kinases (EPHB3, PTPRF, GNAZ, SYK, LYN, EPHA4, BIRC3), transcription factors (TWIST1, PITX2, EYA2, OAS1, MITF, TCF20), and members of the Wnt signalling pathway (AXIN2, WISP1, SFRP). 16440290 2006
Entrez Id: 2139
Gene Symbol: EYA2
EYA2 		0.010 AlteredExpression disease BEFREE Differentially expressed transcripts (89 clones displaying increased expression in DTs and 246 clones displaying increased expression in NF) included genes encoding several receptor and non-receptor tyrosine kinases (EPHB3, PTPRF, GNAZ, SYK, LYN, EPHA4, BIRC3), transcription factors (TWIST1, PITX2, EYA2, OAS1, MITF, TCF20), and members of the Wnt signalling pathway (AXIN2, WISP1, SFRP). 16440290 2006
Entrez Id: 2043
Gene Symbol: EPHA4
EPHA4 		0.010 AlteredExpression disease BEFREE Differentially expressed transcripts (89 clones displaying increased expression in DTs and 246 clones displaying increased expression in NF) included genes encoding several receptor and non-receptor tyrosine kinases (EPHB3, PTPRF, GNAZ, SYK, LYN, EPHA4, BIRC3), transcription factors (TWIST1, PITX2, EYA2, OAS1, MITF, TCF20), and members of the Wnt signalling pathway (AXIN2, WISP1, SFRP). 16440290 2006
Entrez Id: 330
Gene Symbol: BIRC3
BIRC3 		0.010 AlteredExpression disease BEFREE Differentially expressed transcripts (89 clones displaying increased expression in DTs and 246 clones displaying increased expression in NF) included genes encoding several receptor and non-receptor tyrosine kinases (EPHB3, PTPRF, GNAZ, SYK, LYN, EPHA4, BIRC3), transcription factors (TWIST1, PITX2, EYA2, OAS1, MITF, TCF20), and members of the Wnt signalling pathway (AXIN2, WISP1, SFRP). 16440290 2006
Entrez Id: 8840
Gene Symbol: CCN4
CCN4 		0.010 AlteredExpression disease BEFREE Differentially expressed transcripts (89 clones displaying increased expression in DTs and 246 clones displaying increased expression in NF) included genes encoding several receptor and non-receptor tyrosine kinases (EPHB3, PTPRF, GNAZ, SYK, LYN, EPHA4, BIRC3), transcription factors (TWIST1, PITX2, EYA2, OAS1, MITF, TCF20), and members of the Wnt signalling pathway (AXIN2, WISP1, SFRP). 16440290 2006
Entrez Id: 6850
Gene Symbol: SYK
SYK 		0.010 AlteredExpression disease BEFREE Differentially expressed transcripts (89 clones displaying increased expression in DTs and 246 clones displaying increased expression in NF) included genes encoding several receptor and non-receptor tyrosine kinases (EPHB3, PTPRF, GNAZ, SYK, LYN, EPHA4, BIRC3), transcription factors (TWIST1, PITX2, EYA2, OAS1, MITF, TCF20), and members of the Wnt signalling pathway (AXIN2, WISP1, SFRP). 16440290 2006
Entrez Id: 2049
Gene Symbol: EPHB3
EPHB3 		0.010 AlteredExpression disease BEFREE Differentially expressed transcripts (89 clones displaying increased expression in DTs and 246 clones displaying increased expression in NF) included genes encoding several receptor and non-receptor tyrosine kinases (EPHB3, PTPRF, GNAZ, SYK, LYN, EPHA4, BIRC3), transcription factors (TWIST1, PITX2, EYA2, OAS1, MITF, TCF20), and members of the Wnt signalling pathway (AXIN2, WISP1, SFRP). 16440290 2006
Entrez Id: 2781
Gene Symbol: GNAZ
GNAZ 		0.010 AlteredExpression disease BEFREE Differentially expressed transcripts (89 clones displaying increased expression in DTs and 246 clones displaying increased expression in NF) included genes encoding several receptor and non-receptor tyrosine kinases (EPHB3, PTPRF, GNAZ, SYK, LYN, EPHA4, BIRC3), transcription factors (TWIST1, PITX2, EYA2, OAS1, MITF, TCF20), and members of the Wnt signalling pathway (AXIN2, WISP1, SFRP). 16440290 2006
Entrez Id: 5792
Gene Symbol: PTPRF
PTPRF 		0.010 AlteredExpression disease BEFREE Differentially expressed transcripts (89 clones displaying increased expression in DTs and 246 clones displaying increased expression in NF) included genes encoding several receptor and non-receptor tyrosine kinases (EPHB3, PTPRF, GNAZ, SYK, LYN, EPHA4, BIRC3), transcription factors (TWIST1, PITX2, EYA2, OAS1, MITF, TCF20), and members of the Wnt signalling pathway (AXIN2, WISP1, SFRP). 16440290 2006
Entrez Id: 4067
Gene Symbol: LYN
LYN 		0.010 AlteredExpression disease BEFREE Differentially expressed transcripts (89 clones displaying increased expression in DTs and 246 clones displaying increased expression in NF) included genes encoding several receptor and non-receptor tyrosine kinases (EPHB3, PTPRF, GNAZ, SYK, LYN, EPHA4, BIRC3), transcription factors (TWIST1, PITX2, EYA2, OAS1, MITF, TCF20), and members of the Wnt signalling pathway (AXIN2, WISP1, SFRP). 16440290 2006
Entrez Id: 9098
Gene Symbol: USP6
USP6 		0.400 Biomarker disease BEFREE Xenografts of cells overexpressing USP6 in nude mice exhibited clinical and histological features similar to human NF. 21826056 2011
Entrez Id: 9098
Gene Symbol: USP6
USP6 		0.400 FusionGene disease ORPHANET Xenografts of cells overexpressing USP6 in nude mice exhibited clinical and histological features similar to human NF. 21826056 2011
Entrez Id: 4627
Gene Symbol: MYH9
MYH9 		0.320 FusionGene disease ORPHANET Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion. 21826056 2011
Entrez Id: 9098
Gene Symbol: USP6
USP6 		0.400 Biomarker disease BEFREE USP6-induced neoplasms: the biologic spectrum of aneurysmal bone cyst and nodular fasciitis. 23769422 2014
Entrez Id: 9098
Gene Symbol: USP6
USP6 		0.400 Biomarker disease BEFREE These findings further support the oncogenic role of the USP6 protease in mesenchymal neoplasia and expand the biologic potential of NF. 27113271 2016
Entrez Id: 55291
Gene Symbol: PPP6R3
PPP6R3 		0.020 Biomarker disease BEFREE PPP6R3-USP6 amplification: Novel oncogenic mechanism in malignant nodular fasciitis. 27113271 2016
Entrez Id: 9098
Gene Symbol: USP6
USP6 		0.400 Biomarker disease BEFREE USP6 FISH is a useful ancillary test in cases where nodular fasciitis is a potential diagnostic consideration. 27271298 2016
Entrez Id: 9098
Gene Symbol: USP6
USP6 		0.400 AlteredExpression disease BEFREE Ectopic expression of USP6 is known to drive formation of tumors, which recapitulate key features of ABC and nodular fasciitis; however, the identity of USP6's relevant substrates has been obscure. 27440725 2016