Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7099
Gene Symbol: TLR4
TLR4 		0.600 Biomarker disease BEFREE Single-Immunoglobulin Interleukin-1-Related Receptor regulates vulnerability to TLR4-mediated necrotizing enterocolitis in a mouse model. 28846670 2018
Entrez Id: 7099
Gene Symbol: TLR4
TLR4 		0.600 Biomarker disease BEFREE Inflammation and Apoptosis: Dual Mediator Role for Toll-like Receptor 4 in the Development of Necrotizing Enterocolitis. 27849634 2017
Entrez Id: 7099
Gene Symbol: TLR4
TLR4 		0.600 Biomarker disease BEFREE Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis. 24519940 2014
Entrez Id: 7099
Gene Symbol: TLR4
TLR4 		0.600 Biomarker disease CTD_human Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling. 23650378 2013
Entrez Id: 7099
Gene Symbol: TLR4
TLR4 		0.600 Biomarker disease BEFREE A critical role for TLR4 induction of autophagy in the regulation of enterocyte migration and the pathogenesis of necrotizing enterocolitis. 23455503 2013
Entrez Id: 7099
Gene Symbol: TLR4
TLR4 		0.600 Biomarker disease BEFREE Our lead compound, C34, is a 2-acetamidopyranoside (MW 389) with the formula C17H27NO9, which inhibited TLR4 in enterocytes and macrophages in vitro, and reduced systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis. 23776545 2013
Entrez Id: 7099
Gene Symbol: TLR4
TLR4 		0.600 Biomarker disease BEFREE Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice. 22796522 2012
Entrez Id: 7099
Gene Symbol: TLR4
TLR4 		0.600 Biomarker disease RGD Ileal immune dysregulation in necrotizing enterocolitis: role of CD40/CD40L in the pathogenesis of disease. 21240009 2011
Entrez Id: 7099
Gene Symbol: TLR4
TLR4 		0.600 Biomarker disease BEFREE Toll-like receptor-4 inhibits enterocyte proliferation via impaired beta-catenin signaling in necrotizing enterocolitis. 19786028 2010
Entrez Id: 7099
Gene Symbol: TLR4
TLR4 		0.600 AlteredExpression disease BEFREE Platelet-activating factor induces TLR4 expression in intestinal epithelial cells: implication for the pathogenesis of necrotizing enterocolitis. 20976181 2010
Entrez Id: 7099
Gene Symbol: TLR4
TLR4 		0.600 Biomarker disease RGD Changes in intestinal Toll-like receptors and cytokines precede histological injury in a rat model of necrotizing enterocolitis. 19608731 2009
Entrez Id: 7099
Gene Symbol: TLR4
TLR4 		0.600 AlteredExpression disease BEFREE Reciprocal expression and signaling of TLR4 and TLR9 in the pathogenesis and treatment of necrotizing enterocolitis. 19109197 2009
Entrez Id: 7099
Gene Symbol: TLR4
TLR4 		0.600 Biomarker disease LHGDN Reciprocal expression and signaling of TLR4 and TLR9 in the pathogenesis and treatment of necrotizing enterocolitis. 19109197 2009
Entrez Id: 7099
Gene Symbol: TLR4
TLR4 		0.600 Biomarker disease LHGDN A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair. 17878380 2007
Entrez Id: 7099
Gene Symbol: TLR4
TLR4 		0.600 GeneticVariation disease BEFREE Genetic polymorphisms of CD14, toll-like receptor 4, and caspase-recruitment domain 15 are not associated with necrotizing enterocolitis in very low birth weight infants. 16385250 2006
Entrez Id: 1839
Gene Symbol: HBEGF
HBEGF 		0.340 Biomarker disease BEFREE Select growth factors, including epidermal growth factor and heparin-binding epidermal growth factor like growth factor, demonstrate some beneficial effects in experimental and clinical intestinal injury demonstrated in necrotizing enterocolitis. 30771819 2019
Entrez Id: 1839
Gene Symbol: HBEGF
HBEGF 		0.340 GeneticVariation disease BEFREE Association of Heparin-binding EGF-like Growth Factor Polymorphisms With Necrotizing Enterocolitis in Preterm Infants. 28953531 2018
Entrez Id: 1839
Gene Symbol: HBEGF
HBEGF 		0.340 AlteredExpression disease BEFREE Heparin-binding epidermal growth factor-like growth factor overexpression in transgenic mice increases resistance to necrotizing enterocolitis. 20920709 2010
Entrez Id: 1839
Gene Symbol: HBEGF
HBEGF 		0.340 Biomarker disease BEFREE Preclinical neonatal rat studies of heparin-binding EGF-like growth factor in protection of the intestines from necrotizing enterocolitis. 19127210 2009
Entrez Id: 1839
Gene Symbol: HBEGF
HBEGF 		0.340 Therapeutic disease CTD_human Heparin-binding epidermal growth factor-like growth factor reduces intestinal apoptosis in neonatal rats with necrotizing enterocolitis. 16567187 2006
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		0.320 Biomarker disease BEFREE Loss of endothelial nitric oxide synthase exacerbates intestinal and lung injury in experimental necrotizing enterocolitis. 29618412 2018
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		0.320 Biomarker disease BEFREE Contribution of glutaredoxin-1 to S-glutathionylation of endothelial nitric oxide synthase for mesenteric nitric oxide generation in experimental necrotizing enterocolitis. 26845626 2017
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		0.320 Biomarker disease CTD_human Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling. 23650378 2013
Entrez Id: 333929
Gene Symbol: SNAI3
SNAI3 		0.300 Biomarker disease CTD_human The small intestine proteome is changed in preterm pigs developing necrotizing enterocolitis in response to formula feeding. 18806098 2008
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2 		0.300 Biomarker disease CTD_human The small intestine proteome is changed in preterm pigs developing necrotizing enterocolitis in response to formula feeding. 18806098 2008