Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 AlteredExpression disease BEFREE Thus, the predictive value of HER2 overexpression depends on the tumor type, and results of breast cancer trials cannot a priori be extrapolated to digestive cancers. 31170116 2019
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 AlteredExpression disease BEFREE Implication of RICTOR in the mTOR inhibitor-mediated induction of insulin-like growth factor-I receptor (IGF-IR) and human epidermal growth factor receptor-2 (Her2) expression in gastrointestinal cancer cells. 20116405 2010
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker disease BEFREE Preclinical studies in HER2-amplified gastrointestinal cancer models have shown that cotargeting HER2 with a monoclonal antibody and a small molecule is superior to monotherapy with either inhibitor, but the underlying cooperative mechanisms remain unexplored. 26296355 2015
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker disease BEFREE Among these, inhibitors of the epidermal growth factor receptor and HER2/neu pathways now play a major role in the management of gastrointestinal cancers in addition to other solid malignancies. 22229849 2012
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker disease BEFREE Mutations in several genes are reportedly involved in the progression of gastrointestinal cancer, including tumor protein 53 (<i>TP53</i>), APC regulator of WNT signaling pathway (<i>APC</i>), KRAS proto-oncogene GTPase (<i>KRAS</i>) and erb-b2 receptor tyrosine kinase 2 (<i>ERBB2</i>). 31452757 2019
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker disease BEFREE EGFR and HER2 protein expression were determined in a panel of 14 human upper gastrointestinal cancer cell lines and HER2 status was assessed by fluorescent in situ hybridization. 20179222 2010
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 GeneticVariation disease BEFREE Current and future therapies for targeting HER2 mutations in gastrointestinal cancer. 30092682 2018
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker disease BEFREE The purpose of this project was to compare HER2 status in GI cancer brain metastases versus matched prior sites of disease in order to determine if HER2+ disease is more common intracranially. 30373904 2019
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker disease BEFREE Clinical Significance of Glycoprotein Non-metastatic B and Its Association with EGFR/HER2 in Gastrointestinal Cancer. 29344282 2018
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker disease BEFREE Consequently, HER2 targeting is established in breast and upper gastrointestinal tract cancer. 30621632 2019
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker disease BEFREE Currently, predictive biomarkers for gastrointestinal cancers include Her2 overexpression or amplification (gastroesophageal adenocarcinoma), c-Kit overexpression (gastrointestinal stromal tumors) and RAS wild-type (colorectal cancer). 25924988 2015
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker disease BEFREE Update on HER2 testing for breast and upper gastrointestinal tract cancers. 21657840 2011
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker disease BEFREE The HER2/HER3 alteration in gastrointestinal cancers is quite interesting. 26619359 2016
Entrez Id: 324
Gene Symbol: APC
APC
0.320 Biomarker disease BEFREE The down-regulation of miR-122a mediated by aberrant APC/beta-catenin signaling is important to the pathogenesis of gastrointestinal cancers. 19607815 2009
Entrez Id: 324
Gene Symbol: APC
APC
0.320 Biomarker disease BEFREE The mutated genes with positive or negative roles in cell growth or survival in aneuploid gastrointestinal cancer (e.g., APC, K-ras, and p53) are less frequently mutated in near-diploid MMP gastrointestinal tumors. 10383166 1999
Entrez Id: 3090
Gene Symbol: HIC1
HIC1
0.310 GeneticVariation disease BEFREE Together, our data suggest that loss of a gene frequently silenced via epigenetic mechanisms, Hic1, can cooperate with loss of a gene mutated in GI cancer, Apc, to promote tumorigenesis in an in vivo model of multiple intestinal neoplasia. 21297660 2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.100 PosttranslationalModification disease BEFREE To explore the tumor-stromal relationship in esophageal neoplasia, we examined methylation of COX-2 (PTGS2), a gene etiologically associated with the development of gastrointestinal cancers, in adjacent foci of epithelium, subepithelial lymphocytes and non-lymphocytic stromal cells found in sections of normal squamous epithelium, squamous dysplasia and invasive esophageal squamous cell carcinoma. 18632220 2008
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.100 AlteredExpression disease BEFREE Discrepancies between the gene expression, protein expression, and enzymatic activity of thymidylate synthase and dihydropyrimidine dehydrogenase in human gastrointestinal cancers and adjacent normal mucosa. 11251164 2001
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 AlteredExpression disease BEFREE Expression of carcinoembryonic antigen and related genes in lung and gastrointestinal cancers. 1330929 1992
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 Biomarker disease BEFREE Selective gene targeting using the carcinoembryonic antigen (CEA) promoter is useful in gene therapy for gastrointestinal cancer. 11053994 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE All 12 gastrointestinal cancer cell lines carried either a wild-type or mutant p53 gene. 9923540 1999
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.100 AlteredExpression disease BEFREE The cell-free mRNA transcripts in malignant effusions were highly detectable and cell-free TS mRNA in gastrointestinal cancer patients were strongly associated with the sensitivity of primary cancer cells to 5-FU in vitro. 18507058 2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.100 Biomarker disease BEFREE Users of selective COX-2 inhibitors showed a SIR=0.89 (95% CI 0.73 to 1.09) for gastrointestinal cancers. 29982219 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 PosttranslationalModification disease BEFREE Identification of a functional p53 responsive element within the promoter of XAF1 gene in gastrointestinal cancer cells. 20198350 2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.100 Biomarker disease BEFREE Cyclooxygenase-2 and gastrointestinal cancer. 15285921 2004