Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8991
Gene Symbol: SELENBP1
SELENBP1
0.030 Biomarker disease BEFREE Preinduction low DBP less than 70 mmHg or SBP greater than 160 mmHg and not ISH, nor WPP were associated with an increased risk of postoperative complications in noncardiac surgery patients with one or more RCRI components. 30044311 2018
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.030 Biomarker disease BEFREE Preinduction low DBP less than 70 mmHg or SBP greater than 160 mmHg and not ISH, nor WPP were associated with an increased risk of postoperative complications in noncardiac surgery patients with one or more RCRI components. 30044311 2018
Entrez Id: 54535
Gene Symbol: CCHCR1
CCHCR1
0.030 Biomarker disease BEFREE Preinduction low DBP less than 70 mmHg or SBP greater than 160 mmHg and not ISH, nor WPP were associated with an increased risk of postoperative complications in noncardiac surgery patients with one or more RCRI components. 30044311 2018
Entrez Id: 8991
Gene Symbol: SELENBP1
SELENBP1
0.030 Biomarker disease BEFREE In the Dallas Heart Study, 2001 untreated participants 18 to 64 years of age (mean age: 42.3 years; 44% black race) were divided into the following groups based on office blood pressure (BP) measurements: (1) optimal BP (systolic BP [SBP] <120 mm Hg and diastolic BP [DBP] <80 mm Hg; n=837); (2) prehypertension (SBP 120-139 mm Hg and DBP 80-89 mm Hg; n=821); (3) ISH (SBP ≥140 mm Hg and DBP <90 mm Hg; n=121); (4) isolated diastolic hypertension (SBP <140 mm Hg and DBP ≥90 mm Hg; n=44); and (5) systolic-diastolic hypertension (SBP ≥140 mm Hg and DBP ≥90 mm Hg; n=178). 28507172 2017
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.030 Biomarker disease BEFREE In the Dallas Heart Study, 2001 untreated participants 18 to 64 years of age (mean age: 42.3 years; 44% black race) were divided into the following groups based on office blood pressure (BP) measurements: (1) optimal BP (systolic BP [SBP] <120 mm Hg and diastolic BP [DBP] <80 mm Hg; n=837); (2) prehypertension (SBP 120-139 mm Hg and DBP 80-89 mm Hg; n=821); (3) ISH (SBP ≥140 mm Hg and DBP <90 mm Hg; n=121); (4) isolated diastolic hypertension (SBP <140 mm Hg and DBP ≥90 mm Hg; n=44); and (5) systolic-diastolic hypertension (SBP ≥140 mm Hg and DBP ≥90 mm Hg; n=178). 28507172 2017
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.030 Biomarker disease BEFREE Of the remaining 3495, 1838 had ISH (SBP≥140 and DBP<90mmHg) and 240 had SDH (SBP≥140 and DBP≥90mmHg). 28291625 2017
Entrez Id: 8991
Gene Symbol: SELENBP1
SELENBP1
0.030 Biomarker disease BEFREE Of the remaining 3495, 1838 had ISH (SBP≥140 and DBP<90mmHg) and 240 had SDH (SBP≥140 and DBP≥90mmHg). 28291625 2017
Entrez Id: 54535
Gene Symbol: CCHCR1
CCHCR1
0.030 Biomarker disease BEFREE Of the remaining 3495, 1838 had ISH (SBP≥140 and DBP<90mmHg) and 240 had SDH (SBP≥140 and DBP≥90mmHg). 28291625 2017
Entrez Id: 54535
Gene Symbol: CCHCR1
CCHCR1
0.030 Biomarker disease BEFREE In the Dallas Heart Study, 2001 untreated participants 18 to 64 years of age (mean age: 42.3 years; 44% black race) were divided into the following groups based on office blood pressure (BP) measurements: (1) optimal BP (systolic BP [SBP] <120 mm Hg and diastolic BP [DBP] <80 mm Hg; n=837); (2) prehypertension (SBP 120-139 mm Hg and DBP 80-89 mm Hg; n=821); (3) ISH (SBP ≥140 mm Hg and DBP <90 mm Hg; n=121); (4) isolated diastolic hypertension (SBP <140 mm Hg and DBP ≥90 mm Hg; n=44); and (5) systolic-diastolic hypertension (SBP ≥140 mm Hg and DBP ≥90 mm Hg; n=178). 28507172 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.020 AlteredExpression disease BEFREE Angiotensinogen mRNA concentration in adipose tissue from ISH subjects was significantly lower than in adipose tissue from normotensive subjects (p = 0.033). 12081721 2002
Entrez Id: 183
Gene Symbol: AGT
AGT
0.020 GeneticVariation disease BEFREE To determine whether the M235-->T polymorphism (exon 2) of the angiotensinogen gene is associated with hypertension in elderly patients with isolated systolic hypertension [ISH: systolic blood pressure (SBP) > or = 160 mmHg, diastolic blood pressure (DBP) < 90 mmHg) or systolic-diastolic hypertension (SDH: DBP > or = 90 mmHg, SBP > or = 160 mmHg) compared with normotensive controls (SBP < 160 mmHg, DBP < 90 mmHg). 8986904 1996
Entrez Id: 4017
Gene Symbol: LOXL2
LOXL2
0.010 AlteredExpression disease BEFREE Reduced LOXL2 expression protects mice from age-associated vascular stiffening and delays the onset of isolated systolic hypertension, a major consequence of stiffening. 31002285 2019
Entrez Id: 5007
Gene Symbol: OSBP
OSBP
0.010 Biomarker disease BEFREE Patients with isolated systolic hypertension had a significantly smaller reduction in OSBP after 6 months compared with patients with combined systolic/diastolic hypertension (-16.2 mm Hg ± 18.5 vs -9.9 mm Hg ± 33.4; P < .005). 29921526 2018
Entrez Id: 5972
Gene Symbol: REN
REN
0.010 AlteredExpression disease BEFREE Serum plasma renin-angiotensin activity, blood biochemical assays and urinary measurements were determined at the baseline and at the end of the 6 months.At the end of the study, the mean systolic blood pressure (SBP) of the ISH LSSalt group had significantly decreased by 10.18 mm Hg (95% confidence interval (CI): 3.13 to 17.2, P = .006) compared with that of the ISH NSalt group, while the mean SBP only decreased by 5.10 mm Hg (95% CI: -2.02 to 12.2, P = .158) in the NISH LSSalt group compared with that of the NISH NSalt group. 29620663 2018
Entrez Id: 567
Gene Symbol: B2M
B2M
0.010 Biomarker disease BEFREE Our data suggest that serum B2M concentration may be individually associated with MACEs and all-cause death in elderly ISH patients without severe renal insufficiency even after adjusted for creatinine-eGFR and cystatin C. 30294350 2018
Entrez Id: 4987
Gene Symbol: OPRL1
OPRL1
0.010 Biomarker disease BEFREE Safety, Tolerability, and Antihypertensive Effect of SER100, an Opiate Receptor-Like 1 (ORL-1) Partial Agonist, in Patients With Isolated Systolic Hypertension. 28032481 2017
Entrez Id: 1628
Gene Symbol: DBP
DBP
0.010 Biomarker disease BEFREE In the Dallas Heart Study, 2001 untreated participants 18 to 64 years of age (mean age: 42.3 years; 44% black race) were divided into the following groups based on office blood pressure (BP) measurements: (1) optimal BP (systolic BP [SBP] <120 mm Hg and diastolic BP [DBP] <80 mm Hg; n=837); (2) prehypertension (SBP 120-139 mm Hg and DBP 80-89 mm Hg; n=821); (3) ISH (SBP ≥140 mm Hg and DBP <90 mm Hg; n=121); (4) isolated diastolic hypertension (SBP <140 mm Hg and DBP ≥90 mm Hg; n=44); and (5) systolic-diastolic hypertension (SBP ≥140 mm Hg and DBP ≥90 mm Hg; n=178). 28507172 2017
Entrez Id: 4314
Gene Symbol: MMP3
MMP3
0.010 GeneticVariation disease BEFREE MMP3 and MMP9 genes variant seem to contribute to the development of isolated systolic hypertension by affecting arterial stiffness and endothelial function. 23794948 2013
Entrez Id: 4312
Gene Symbol: MMP1
MMP1
0.010 GeneticVariation disease BEFREE This study was to investigate the associations of MMP1,3,9 and TIMP3 Genes polymorphism with isolated systolic hypertension. 23794948 2013
Entrez Id: 7078
Gene Symbol: TIMP3
TIMP3
0.010 GeneticVariation disease BEFREE This study was to investigate the associations of MMP1,3,9 and TIMP3 Genes polymorphism with isolated systolic hypertension. 23794948 2013
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.010 GeneticVariation disease BEFREE MMP3 and MMP9 genes variant seem to contribute to the development of isolated systolic hypertension by affecting arterial stiffness and endothelial function. 23794948 2013
Entrez Id: 2006
Gene Symbol: ELN
ELN
0.010 GeneticVariation disease BEFREE Variants within the ELN gene are associated with increased risk of ISH and aortic stiffness in the Chinese Han population. 19282817 2009
Entrez Id: 7204
Gene Symbol: TRIO
TRIO
0.010 Biomarker disease BEFREE Haplotypes of TGGTA and TGAT- were also significantly associated with ISH (P = 0.0001, P(corr) = 0.0021; P = 0.0023, P(corr) = 0.0483). 19282817 2009
Entrez Id: 10993
Gene Symbol: SDS
SDS
0.010 Biomarker disease BEFREE Community subjects (n = 46) aged > or = 60 years classified as isolated systolic hypertension [ISH; systolic blood pressure (SBP) > or = 160, diastolic blood pressure (DBP) < 90 mmHg, n = 19], diastolic +/- systolic hypertension (SDH; DBP > or = 90 mmHg, n = 10) and normotension (SBP < 160, DBP < 90 mmHg, n = 17). 11403353 2001
Entrez Id: 1757
Gene Symbol: SARDH
SARDH
0.010 Biomarker disease BEFREE Community subjects (n = 46) aged > or = 60 years classified as isolated systolic hypertension [ISH; systolic blood pressure (SBP) > or = 160, diastolic blood pressure (DBP) < 90 mmHg, n = 19], diastolic +/- systolic hypertension (SDH; DBP > or = 90 mmHg, n = 10) and normotension (SBP < 160, DBP < 90 mmHg, n = 17). 11403353 2001